DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS15 and SLC17A8

DIOPT Version :9

Sequence 1:	NP_611375.2	Gene:	MFS15 / 37168	FlyBaseID:	FBgn0034392	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_647480.1	Gene:	SLC17A8 / 246213	HGNCID:	20151	Length:	589	Species:	Homo sapiens

Alignment Length:	474	Identity:	158/474 - (33%)
Similarity:	248/474 - (52%)	Gaps:	27/474 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RHLQCILVFFGLAVAYSLRVNLSVAIVAMTDRNA----SNPDF--PEFDWNESTKSYLLSSFFWG 85
            |::..|:...|..:::.:|.||.||||.|.:.:.    ..|:.  .:|:|:..|...:..|||||
Human    75 RYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWG 139

  Fly    86 YVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLTPFCA-VNGGWTVVVVLRAVQGLCQGVIFPS 149
            |::||||||::|..:.|..:....:.:.|.|.:..|..| |:.|  .|:.:|.:|||.:||.:|:
Human   140 YIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYG--CVMCVRILQGLVEGVTYPA 202

  Fly   150 THTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIASSSLGWPSTFYIPGCVGIVWSFVWL 214
            .|...|||||..||.||...::.||..|.||.:.::|.:. ..:||.|.|||.|..||:|...||
Human   203 CHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLV-QYIGWSSVFYIYGMFGIIWYMFWL 266

  Fly   215 YLCSSTPAQHPTITPNERRFIESS-GQARRPSDAGREEQPRPPTPWWRIFTSVPFLVLVLAHCAN 278
            ......||.||||:..|:.:||:| |:.     |......:..|||.|.|||:|...:::|:...
Human   267 LQAYECPAAHPTISNEEKTYIETSIGEG-----ANVVSLSKFSTPWKRFFTSLPVYAIIVANFCR 326

  Fly   279 NWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTVIPLGFSRK 343
            :|.|:.||...|.:.:.|.|..|...|.|||:|:..|.::..:...|:|.|:.| .::.....||
Human   327 SWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSR-QILTTTAVRK 390

  Fly   344 FFNT--LGMWLPMLALIGLGYITEGEANVRLAIGLLTAAVATNSATYLGFHVNHIDLSPNYAGTL 406
            ..|.  .||...:|.::|..: |:|     :||..|..||..:.....||:|||:|::|.||..|
Human   391 IMNCGGFGMEATLLLVVGFSH-TKG-----VAISFLVLAVGFSGFAISGFNVNHLDIAPRYASIL 449

  Fly   407 MGITNCAANFMSILAPLIVGLIVWDETNPAQWRIVFFFTAFVYFIGNLLFMLFGRTRVQPWNSRP 471
            |||:|.......::.|||||.:...:|. .:|:.||...|.|::.|.:.:.:|.....|.| :.|
Human   450 MGISNGVGTLSGMVCPLIVGAMTRHKTR-EEWQNVFLIAALVHYSGVIFYGVFASGEKQEW-ADP 512

  Fly   472 TTRTPSPGGGGERDEGTED 490
            ...:....|..::||..|:
Human   513 ENLSEEKCGIIDQDELAEE 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS15	NP_611375.2	2A0114euk	18..469	CDD:129972	153/451 (34%)
MFS15	NP_611375.2	MFS	31..459	CDD:119392	149/437 (34%)
SLC17A8	NP_647480.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..61
		2A0114euk	75..513	CDD:129972	153/454 (34%)
		MFS	80..502	CDD:119392	149/437 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148608
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.760