DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS15 and Slc17a8

DIOPT Version :9

Sequence 1:	NP_611375.2	Gene:	MFS15 / 37168	FlyBaseID:	FBgn0034392	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_892004.1	Gene:	Slc17a8 / 216227	MGIID:	3039629	Length:	601	Species:	Mus musculus

Alignment Length:	474	Identity:	158/474 - (33%)
Similarity:	248/474 - (52%)	Gaps:	27/474 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RHLQCILVFFGLAVAYSLRVNLSVAIVAMTDRNA----SNPDF--PEFDWNESTKSYLLSSFFWG 85
            |::..::...|..:::.:|.||.||||.|.:.:.    ..|:.  .:|:|:..|...:..|||||
Mouse    88 RYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWG 152

  Fly    86 YVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLTPFCA-VNGGWTVVVVLRAVQGLCQGVIFPS 149
            |:|||||||::|..:.|..:....:.:.|.|.:..|..| |:.|  .|:.:|.:|||.:||.:|:
Mouse   153 YIVTQIPGGFISNKFAASRVFGAAIFLTSTLNMFIPSAARVHYG--CVMGVRILQGLVEGVTYPA 215

  Fly   150 THTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIASSSLGWPSTFYIPGCVGIVWSFVWL 214
            .|...|||||..||.||...::.||..|.||.:.::|.:. ..:||.|.|||.|..||:|...||
Mouse   216 CHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLV-QYIGWASVFYIYGMFGIIWYMFWL 279

  Fly   215 YLCSSTPAQHPTITPNERRFIESS-GQARRPSDAGREEQPRPPTPWWRIFTSVPFLVLVLAHCAN 278
            ......||.||||:..||.:||:| |:....:...:..     |||.|.|||:|...:::|:...
Mouse   280 LQAYECPAAHPTISNAERTYIETSIGEGANLASLSKFN-----TPWRRFFTSLPVYAIIVANFCR 339

  Fly   279 NWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTVIPLGFSRK 343
            :|.|:.||...|.:.:.|.|..|...|.|||:|:..|.::..:...|:|.|:.| .::.....||
Mouse   340 SWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSR-KILTTTAVRK 403

  Fly   344 FFNT--LGMWLPMLALIGLGYITEGEANVRLAIGLLTAAVATNSATYLGFHVNHIDLSPNYAGTL 406
            ..|.  .||...:|.::|..: |:|     :||..|..||..:.....||:|||:|::|.||..|
Mouse   404 IMNCGGFGMEATLLLVVGFSH-TKG-----VAISFLVLAVGFSGFAISGFNVNHLDIAPRYASIL 462

  Fly   407 MGITNCAANFMSILAPLIVGLIVWDETNPAQWRIVFFFTAFVYFIGNLLFMLFGRTRVQPWNSRP 471
            |||:|.......::.|||||.:...:|. .:|:.||...|.|::.|.:.:.:|.....|.| :.|
Mouse   463 MGISNGVGTLSGMVCPLIVGAMTKHKTR-EEWQNVFLIAALVHYSGVIFYGVFASGEKQDW-ADP 525

  Fly   472 TTRTPSPGGGGERDEGTED 490
            ...:....|..::||..|:
Mouse   526 ENLSEDKCGIIDQDELAEE 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS15	NP_611375.2	2A0114euk	18..469	CDD:129972	153/451 (34%)
MFS15	NP_611375.2	MFS	31..459	CDD:119392	149/437 (34%)
Slc17a8	NP_892004.1	2A0114euk	88..526	CDD:129972	153/454 (34%)
		MFS	93..515	CDD:119392	149/437 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	576..601
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830