DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15093 and Glyr1

DIOPT Version :9

Sequence 1:	NP_001188972.1	Gene:	CG15093 / 37166	FlyBaseID:	FBgn0034390	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_001007801.1	Gene:	Glyr1 / 360477	RGDID:	1309459	Length:	552	Species:	Rattus norvegicus

Alignment Length:	304	Identity:	82/304 - (26%)
Similarity:	132/304 - (43%)	Gaps:	41/304 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KNIGFVGLGNMGANMASNLIKAGHKLHVFDISKPACDGLAAKGATVYAKTSELAKNSDFVITMLP 93
            |.|||:|||.||:.:.|||:|.||.:.|::.:...||....:||.:....:|:....|.....:.
  Rat   267 KKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVS 331

  Fly    94 NNAIVDASYDEM-----TADGVNKDTIFIDSSTISPDLVKSLQKKISAKGARFIDAPVSGGVPGA 153
            :   ..|:.|.:     ...|:.....::|.||:..|.|..|.:.|.::|.||::|||||....:
  Rat   332 D---PKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLS 393

  Fly   154 EQATLTFMVGGTEAEYNAVKAVLECMGKKITHCGVYGMGQAAKLCNNMMLAISMI------GVSE 212
            ....|..:..|....|....:..:.|||.....|  .:|.|||    |||.::|:      .::|
  Rat   394 NDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLG--EVGNAAK----MMLIVNMVQGSFMATIAE 452

  Fly   213 AMNLAVRQGLDANVFAEIINSS-------TGRCWASEIYNPVPGVCPSAPANRDYAGGFSSALIT 270
            .:.||...|.......:|:|..       ..:|     .|.:.|         ::...|....|.
  Rat   453 GLTLAQVTGQSQQTLLDILNQGQLASIFLDQKC-----QNILQG---------NFKPDFYLKYIQ 503

  Fly   271 KDLGLASGVANASNSPIPLGSLAHKVYQSLCDKGLGNKDFSVVY 314
            |||.||..:.:|.|.|.|:.:.|::||:........:.|.|.||
  Rat   504 KDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVY 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15093	NP_001188972.1	NAD_binding_2	29..187	CDD:281445	46/162 (28%)
		HIBADH	33..318	CDD:130753	79/300 (26%)
		NAD_binding_11	190..314	CDD:291499	33/136 (24%)
Glyr1	NP_001007801.1	N_Pac_NP60	6..90	CDD:99897
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..187
		NADB_Rossmann	<209..>301	CDD:419666	16/33 (48%)
		Interaction with histone H3. /evidence=ECO:0000250\|UniProtKB:Q49A26	213..216
		Interaction with KDM1B. /evidence=ECO:0000250\|UniProtKB:Q49A26	215..224
		MmsB	267..550	CDD:224995	82/304 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810