DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mctp and QKY

DIOPT Version :9

Sequence 1:	NP_001261078.1	Gene:	Mctp / 37165	FlyBaseID:	FBgn0034389	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_177610.1	Gene:	QKY / 843811	AraportID:	AT1G74720	Length:	1081	Species:	Arabidopsis thaliana

Alignment Length:	879	Identity:	192/879 - (21%)
Similarity:	323/879 - (36%)	Gaps:	231/879 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 MEGRIDEHPENG--------------SAG---CSPPELSTQQQLEALQANELR---RKREAQLRQ 232
            |:|..|.||...              |||   ..|||:...|.......:.:|   |........
plant   242 MQGPNDNHPHRNDNHPQRPPSPPPPPSAGEVHYYPPEVRKMQVGRPPGGDRIRVTKRPPNGDYSP 306

  Fly   233 FVFFQLRVHLKSGSDLVAMDKN-----GLSDP--------------------YVKFKVGGRLLHK 272
            .|     ::.|:|.....|:|.     .|.:|                    |||.:.....:..
plant   307 RV-----INSKTGGGETTMEKKTHHPYNLVEPMQYLFVRIVKARGLPPNESAYVKVRTSNHFVRS 366

  Fly   273 SRTIHR-----DLNPVWDEVFIV---PIEDPFQPIIVKVFDYDWGLQDDFMGSAKLDLTQLELGK 329
            ...::|     | :|.|::||.:   ..:.......:::..:| ...:.|:|....||:::.:..
plant   367 KPAVNRPGESVD-SPEWNQVFALGHNRSDSAVTGATLEISAWD-ASSESFLGGVCFDLSEVPVRD 429

  Fly   330 AEDIHL----QLCDSSG---NGGSGLGEILINLTLWPRSQEDKEM---------HF-QRNSKLAE 377
            ..|..|    ...:.||   |.|...|:  |.|::|..:|.|:..         |. ...||:.:
plant   430 PPDSPLAPQWYRLEGSGADQNSGRISGD--IQLSVWIGTQVDEAFPEAWSSDAPHVAHTRSKVYQ 492

  Fly   378 SSKRLKSQIWSSVVTILLVKAKDLPLAEDGSKLN--DTHFKFRLGNEKYKSK------SSWTERW 434
            |.|     :|...||:|  :|:||.:|.:...|.  :...|.:||.:..:::      .|.:..|
plant   493 SPK-----LWYLRVTVL--EAQDLHIAPNLPPLTAPEIRVKAQLGFQSARTRRGSMNNHSGSFHW 550

  Fly   435 LEQF----------DLHLFDEDQNLEIALWNRNTLYGKAIIDL-SVFQRENTHGI---WKPLED- 484
            .|..          .|.|..||:..:.|     ||.|.|:|.: |:.||.:...:   |..||.
plant   551 HEDMIFVAGEPLEDCLVLMVEDRTTKEA-----TLLGHAMIPVSSIEQRIDERFVPSKWHTLEGE 610

  Fly   485 -------------------CPGEVHLMLTISG-----TTALETISDLKAFKEDPREAQLLRERYK 525
                               | |.:.|.|.:.|     ..|....||.:     |...||.:.
plant   611 GGGGGGGGGPGGGGGGGPYC-GRISLRLCLEGGYHVLEEAAHVCSDFR-----PTAKQLWKP--- 666

  Fly   526 FLRCLQNLRDVGHLTVKVFGATGL--AAADIGGK--SDPFCVLELGNARLQTQTEYKTLTPNWNK 586
                     .:|.|.:.:.||.||  ..|..|||  :|.:||.:.|...::|:|...:..|.|::
plant   667 ---------PIGILELGILGARGLLPMKAKNGGKGSTDAYCVAKYGKKWVRTRTITDSFDPRWHE 722

  Fly   587 IFTFNVKDITQVLEITVFD---------EDR-DHRVEFLGKLVIPLLRIKSGVKRWYTLKDKNLC 641
            .:|:.|.|...||.:.|||         :|| |.|:   ||:.|.:..::|  .:.||.....|.
plant   723 QYTWQVYDPCTVLTVGVFDNWRMFSDASDDRPDTRI---GKIRIRVSTLES--NKVYTNSYPLLV 782

  Fly   642 VRAKGNSPQIQLELTVVW---SEIRAVCRA----LQPKEEKL-----IQQEA------KFKRQLF 688
            :...|.....::|:.|.:   |.:..||.|    |.|:...:     .||:|      |......
plant   783 LLPSGMKKMGEIEVAVRFACPSLLPDVCAAYGQPLLPRMHYIRPLGVAQQDALRGAATKMVAAWL 847

  Fly   689 LRNVNRL-KEIIMDILDA---------------------------ARYVQSCFEWESPVRSSIAF 725
            .|....| .|::..:|||                           |:::.:...|.:||.:.:..
plant   848 ARAEPPLGPEVVRYMLDADSHAWSMRKSKANWYRIVGVLAWAVGLAKWLDNIRRWRNPVTTVLVH 912

  Fly   726 VFWIVACVYGDLETVPLVLLLIILKNWLVRL---ITGTTD-----AAAHYDYEYDEDDDDDKEKE 782
            :.::|...|.||......|.::::..|..|.   |....|     |......|.||:.|......
plant   913 ILYLVLVWYPDLVVPTAFLYVVMIGVWYYRFRPKIPAGMDIRLSQAETVDPDELDEEFDTIPSSR 977

  Fly   783 EKKSIKERLQAIQEVSQTVQNTIGYLASLGESTINTFNFSVPELTWLAVVLLLGAILVLHFVPLR 847
            ..:.|:.|...::.::..||..:|..|:.||......::..|..|.|.:.:.|...:||:.||.:
plant   978 RPEVIRARYDRLRILAVRVQTILGDFAAQGERIQALVSWRDPRATKLFIAICLVITIVLYAVPAK 1042

  Fly   848 WLLLFWGLMKFSRRLLRPNTIPNNELLDFLSRVP 881
            .:.:..|.......:.| :|:|... |:|..|:|
plant  1043 MVAVALGFYYLRHPMFR-DTMPTAS-LNFFRRLP 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mctp	NP_001261078.1	C2A_MCTP_PRT	237..357	CDD:176007	29/159 (18%)
		C2B_MCTP_PRT	390..497	CDD:176022	34/148 (23%)
		C2C_MCTP_PRT	537..658	CDD:176023	39/134 (29%)
		PRT_C	<789..893	CDD:285560	23/93 (25%)
QKY	NP_177610.1	C2A_MCTP_PRT_plant	18..148	CDD:175989
		C2B_MCTP_PRT_plant	336..466	CDD:176024	24/133 (18%)
		C2C_MCTP_PRT_plant	498..658	CDD:175986	38/172 (22%)
		C2D_MCTP_PRT_plant	670..797	CDD:176025	38/131 (29%)
		PRT_C	926..1080	CDD:337028	34/151 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I1886
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D234298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101057
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.870