DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mctp and ESYT3

DIOPT Version :9

Sequence 1:NP_001261078.1 Gene:Mctp / 37165 FlyBaseID:FBgn0034389 Length:982 Species:Drosophila melanogaster
Sequence 2:NP_001309760.1 Gene:ESYT3 / 83850 HGNCID:24295 Length:886 Species:Homo sapiens


Alignment Length:608 Identity:127/608 - (20%)
Similarity:204/608 - (33%) Gaps:247/608 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   238 LRVHLKSGSDLVAMDK----NGLSDPYVKFKVGGRLLH-KSRTIHRDLNPVWDEVF-IVPIEDPF 296
            :||||.....|...|.    .|.||||.|..:|  |.| :||||:|:|||.|:||| .:..|.|.
Human   308 IRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIG--LQHFRSRTIYRNLNPTWNEVFEFMVYEVPG 370

  Fly   297 QPIIVKVFDYDWGLQDDFMGSAKLDLTQLELGKAEDIHLQLCDSSGNGGSGLGEILINLTLWPRS 361
            |.:.|.::|.|.. :|||:||.::.|..:...:..|....|.|::.      |.:.:.|. |...
Human   371 QDLEVDLYDEDTD-RDDFLGSLQICLGDVMTNRVVDEWFVLNDTTS------GRLHLRLE-WLSL 427

  Fly   362 QEDKEMHFQRNSKLAESSKRLKSQIWSSVVTILLVKAKDLP-----------------------L 403
            ..|:|:..:.:..|:           ::::.:.|..|.:||                       :
Human   428 LTDQEVLTEDHGGLS-----------TAILVVFLESACNLPRNPFDYLNGEYRAKKLSRFARNKV 481

  Fly   404 AEDGSKLNDTHFKFRLGNEKYKSKSS-------WTERW--------LEQFDLHLFDEDQN----- 448
            ::|.|    ::.|..:|.:.:.||:.       |::.:        .|:..|.:.|:||.     
Human   482 SKDPS----SYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDDQECALGM 542

  Fly   449 LEIAL-----WNRNTLYGKAIID----------------LSVFQRE------------------- 473
            ||:.|     :...||..:..:|                |.|.:||                   
Human   543 LEVPLCQILPYADLTLEQRFQLDHSGLDSLISMRLVLRFLQVEERELGSPYTGPEALKKGPLLIK 607

  Fly   474 ----NTHGIWKPLED------CP------------------------------------------ 486
                |.....:|.|:      ||                                          
Human   608 KVATNQGPKAQPQEEGPTDLPCPPDPASDTKDVSRSTTTTTSATTVATEPTSQETGPEPKGKDSA 672

  Fly   487 -------GE----VHLMLTISGTTALETISDLKAFK----------------------------- 511
                   ||    ..:.||:.|..:...|...:..|                             
Human   673 KRFCEPIGEKKSPATIFLTVPGPHSPGPIKSPRPMKCPASPFAWPPKRLAPSMSSLNSLASSCFD 737

  Fly   512 ----------EDPREAQL----LRERYKFL-RCLQNLRDVGHLTVKVFGATGLAAADIGGKSDPF 561
                      .|.|..||    |..||..| ||         |:|.:.|...|......| :||:
Human   738 LADISLNIEGGDLRRRQLGEIQLTVRYVCLRRC---------LSVLINGCRNLTPCTSSG-ADPY 792

  Fly   562 CVLEL-----GNARLQTQTEYKTLTPNWNKIFTF-----NVKDITQVLEITVFDED--RDHRVEF 614
            ..:.|     ...|.:|..:.|||.|.:::.|.|     .||  .:.|::.|.:..  ..||.:.
Human   793 VRVYLLPERKWACRKKTSVKRKTLEPLFDETFEFFVPMEEVK--KRSLDVAVKNSRPLGSHRRKE 855

  Fly   615 LGKLVIPLLR--IKSGVKRWYTL 635
            |||::|.|.:  :..|..:||.|
Human   856 LGKVLIDLSKEDLIKGFSQWYEL 878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MctpNP_001261078.1 C2A_MCTP_PRT 237..357 CDD:176007 44/124 (35%)
C2B_MCTP_PRT 390..497 CDD:176022 35/252 (14%)
C2C_MCTP_PRT 537..658 CDD:176023 31/113 (27%)
PRT_C <789..893 CDD:285560
ESYT3NP_001309760.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
SMP_LBD 114..290 CDD:293652
C2A_C2C_Synaptotagmin_like 306..424 CDD:176037 44/125 (35%)
C2B_Synaptotagmin-like 445..568 CDD:176015 22/126 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 613..673 4/59 (7%)
C2C_KIAA1228 755..879 CDD:175996 38/136 (28%)
Required for phosphatidylinositol 4,5-bisphosphate-dependent location at the cell membrane. /evidence=ECO:0000250 801..808 1/6 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2311
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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