DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mctp and AT4G11610

DIOPT Version :9

Sequence 1:	NP_001261078.1	Gene:	Mctp / 37165	FlyBaseID:	FBgn0034389	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_192898.2	Gene:	AT4G11610 / 826766	AraportID:	AT4G11610	Length:	1011	Species:	Arabidopsis thaliana

Alignment Length:	989	Identity:	212/989 - (21%)
Similarity:	369/989 - (37%)	Gaps:	281/989 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PHGSPSLQQSQRLGKHLSKS-ASELNGHDCHLSESPHISPKRAKSAVAQQLAGVSSGGVASGVGV 101
            |:.:...|.....|.:.|.| |:|.:.|:.|   ..|..||.....:..:.|..|
plant   174 PNSAQEHQHQHPQGPNQSSSLAAEQDNHNEH---HHHYVPKHQVDEMRSEPARPS---------- 225

  Fly   102 LQKTHGFFNNLRHRWSRAKSKDRLGRKSPSDF-LEESTDYAADYSSEGSSVTHSPRHRSTTIGGS 165
                     .|.|..|.|.::       |:|| |:|::.:..     |..|          :||.
plant   226 ---------KLVHAHSIASAQ-------PADFALKETSPHLG-----GGRV----------VGGR 259

  Fly   166 PLAREFRATAKMAQVIQRFGGSMEGRIDEHPENGSAGCSPPELSTQQQLEALQANELRRKREAQL 230
            .:.::..||                                  ||...:|.:
plant   260 VIHKDKTAT----------------------------------STYDLVERM------------- 277

  Fly   231 RQFVFFQLRVHLKSGSDLVAMDKNGLSDPYVKFKVGGRLLHKSRTIH--RDLNPVWDEVFIVPIE 293
                 :.|.|.:....:|..||..|..||:|:.:||.   :|..|.|  :..:|.|::||....|
plant   278 -----YFLYVRVVKARELPIMDITGSVDPFVEVRVGN---YKGITRHFEKRQHPEWNQVFAFAKE 334

  Fly   294 DPFQPII-VKVFDYDWGLQDDFMGSAKLDLTQLELGKAEDIHL-----QLCDSSGNGGSGLGEIL 352
            .....:: |.|.|.|. |:||::|..:.|:..:.|....|..|     :|.|..|.  ...||::
plant   335 RMQASVLEVVVKDKDL-LKDDYVGFVRFDINDVPLRVPPDSPLAPQWYRLEDKKGE--KIKGELM 396

  Fly   353 INLTLWPRSQEDKEMHFQRNSKLA-------ESSKRLKSQIWSS----VVTILLVKAKDLPLAED 406
              |.:|..:|.|:......:|..|       ..|..|:|:::.:    .|.:.:::|:|| :..|
plant   397 --LAVWIGTQADEAFSDAWHSDAAMPVDCSPAISAVLRSKVYHAPRLWYVRVNVIEAQDL-IPTD 458

  Fly   407 GSKLNDTHFKFRLGNEKYKSK--------SSWTERWL----EQFDLHLF--DEDQNLEIALWNRN 457
            .::..|.:.|.:|||:..|::        :.|.|.:|    |.|:.||.  .||:    ....::
plant   459 KTRFPDVYVKAQLGNQVMKTRPCQARTLGAVWNEDFLFVVAEPFEDHLVLTVEDR----VAPGKD 519

  Fly   458 TLYGKAIIDL-SVFQRENTHGI---W----KPL---------EDCPGEVHLMLTISG-----TTA 500
            .:.|:..|.| :|.:|.:.|.|   |    :|:         |.....:||.:.:.|     ..:
plant   520 EIVGRTYIPLNTVEKRADDHMIHARWYNLERPVIVDVDQLKREKFSMRIHLRVCLEGGYHVLDES 584

  Fly   501 LETISDLKAFKEDPREAQLLRERYKFLRCLQNLRDVGHLTVKVFGATGL---AAADIGGKSDPFC 562
            ....|||:     |....|.|:            .:|.|.:.:..|.||   ...:..|.||.||
plant   585 THYSSDLR-----PSARPLWRQ------------PIGVLELGILNAVGLHPMKTREGRGTSDTFC 632

  Fly   563 VLELGNARLQTQTEYKTLTPNWNKIFTFNVKDITQVLEITVFDE----DRDHRVEFLGKLVIPLL 623
            |.:.|...::|:|....|.|.:|:.:|:.|.|...||.:.|||.    ::.:|...:||:.|.|.
plant   633 VGKYGQKWVRTRTMVDNLCPKYNEQYTWEVFDPATVLTVGVFDNGQLGEKGNRDVKIGKIRIRLS 697

  Fly   624 RIKSGVKRWYTLKDKNLCVRAKGNSPQIQLELTVVWSEIRAVC-----------RALQPK----- 672
            .:::|  |.||.....|.:...|.....:|.:.|     |..|           :.|.||
plant   698 TLETG--RIYTHSYPLLVLHPTGVKKMGELHMAV-----RFTCISFANMLYQYSKPLLPKMHYVR 755

  Fly   673 -----EEKLIQQEA----------------------------------KFKRQLFLRNVNRLKEI 698
                 ::.:::.:|                                  |.|...|     |:..:
plant   756 PFSVMQQDMLRHQAVNIVAARLGRAEPPLRKEIIEFMSDTDSHLWSMRKSKANFF-----RMMTV 815

  Fly   699 IMDILDAARYVQSCFEWESPVRSSIAFVFWIVACVYGD--LETVPLVLLLIILKNWLVR------ 755
            ...::...::......|.:|:.:.:..|.:::.....:  |.|:.|.:.||.|.|:..|
plant   816 FSGVIAVGKWFSDICSWRNPITTVLVHVLFLMLVCLPELILPTMFLYMFLIGLWNYRFRPRYPPH 880

  Fly   756 LITGTTDAAAHYDYEYDEDDDDDKEKEEKKSIKERLQAIQEVSQTVQNTIGYLASLGESTINTFN 820
            :.|..:.|.|.:..|.||:.|..........::.|...::.|:..:|..||.||:.||......:
plant   881 MNTKISQAEAVHPDELDEEFDTFPTTRNPDMVRLRYDRLRSVAGRIQTVIGDLATQGERFQALLS 945

  Fly   821 FSVPELTWLAVVLLLGAILVLHFVPLRWLLLFWGLMKFSRRLLRPNTIPNNELLDFLSRVPDNEE 885
            :..|..|.:.|:|...|.:|....|::.::...|.  |:.|..|           |..|:| :..
plant   946 WRDPRATAIFVILCFIAAIVFFITPIQIVVALAGF--FTMRHPR-----------FRHRLP-SVP 996

  Fly   886 INQYRELPPSAPTD 899
            :|.:|.||  |.||
plant   997 VNFFRRLP--ARTD 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mctp	NP_001261078.1	C2A_MCTP_PRT	237..357	CDD:176007	37/127 (29%)
		C2B_MCTP_PRT	390..497	CDD:176022	32/137 (23%)
		C2C_MCTP_PRT	537..658	CDD:176023	37/127 (29%)
		PRT_C	<789..893	CDD:285560	25/103 (24%)
AT4G11610	NP_192898.2	C2A_MCTP_PRT_plant	7..133	CDD:175989
		C2B_MCTP_PRT_plant	279..403	CDD:176024	38/131 (29%)
		C2C_MCTP_PRT_plant	443..593	CDD:175986	36/159 (23%)
		C2D_MCTP_PRT_plant	605..728	CDD:176025	36/124 (29%)
		PRT_C	856..1011	CDD:285560	45/169 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I1886
OMA	1	1.010	-	-		QHG59961
OrthoDB	1	1.010	-	-		D234298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101057
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.880