DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mctp and AT3G57880

DIOPT Version :9

Sequence 1:	NP_001261078.1	Gene:	Mctp / 37165	FlyBaseID:	FBgn0034389	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001327704.1	Gene:	AT3G57880 / 824957	AraportID:	AT3G57880	Length:	773	Species:	Arabidopsis thaliana

Alignment Length:	819	Identity:	183/819 - (22%)
Similarity:	323/819 - (39%)	Gaps:	195/819 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 DEHPENGSAGCSPPEL-STQQQLEALQANELRRKREAQLRQFVFFQLRVHLKSGSDLVAMDKNGL 256
            :..|..|....|..:| ||...:|.:|                  .|.|.:....:|...|..|.
plant    13 ETRPHLGGGKLSGDKLTSTYDLVEQMQ------------------YLYVRVVKAKELPGKDMTGS 59

  Fly   257 SDPYVKFKVGGRLLHKSRTIH--RDLNPVWDEVFIVP---IEDPFQPIIVKVFDYDWGLQDDFMG 316
            .||||:.|:|.   :|..|.|  :..||.|::||...   |:..|....||..|:   ::||.:|
plant    60 CDPYVEVKLGN---YKGTTRHFEKKSNPEWNQVFAFSKDRIQASFLEATVKDKDF---VKDDLIG 118

  Fly   317 SAKLDLTQLELGKAEDIHL-----QLCDSSGNGGSGLGEILINLTLWPRSQEDKEMHFQRNSKLA 376
            ....||.::......|..|     :|.|..|:  ...||::  |.:|..:|.|:......:|..|
plant   119 RVVFDLNEVPKRVPPDSPLAPQWYRLEDRKGD--KVKGELM--LAVWFGTQADEAFPEAWHSDAA 179

  Fly   377 -----ESSKRLKSQIWSS----VVTILLVKAKDLPLAEDGSKLNDTHFKFRLGNEKYKSKSS--- 429
                 ::...::|:::.|    .:.:.:::|:|| :..|..:..:.:.|..:||:..:::.|
plant   180 TVSGTDALANIRSKVYLSPKLWYLRVNVIEAQDL-IPTDKQRYPEVYVKAIVGNQALRTRVSQSR 243

  Fly   430 -----WTERWL----EQFD--LHLFDEDQNLEIALWNRNTLYGKAIIDLSVFQRENTH----GIW 479
                 |.|..:    |.|:  |.|..||:    ...|::.:.|:..|.|....|...|    ..|
plant   244 TINPMWNEDLMFVAAEPFEEPLILSVEDR----VAPNKDEVLGRCAIPLQYLDRRFDHKPVNSRW 304

  Fly   480 KPLED---CPGE---------VHLMLTISG-----TTALETISDLKAFKEDPREAQLLRERYKFL 527
            ..||.   ..||         :|:.:.:.|     ..:....|||:     |...||.:.
plant   305 YNLEKHIMVDGEKKETKFASRIHMRICLEGGYHVLDESTHYSSDLR-----PTAKQLWKP----- 359

  Fly   528 RCLQNLRDVGHLTVKVFGATGL---AAADIGGKSDPFCVLELGNARLQTQTEYKTLTPNWNKIFT 589
                   ::|.|.:.:..||||   ...|..|.:|.:||.:.|...::|:|...:.||.||:.:|
plant   360 -------NIGVLELGILNATGLMPMKTKDGRGTTDAYCVAKYGQKWIRTRTIIDSFTPRWNEQYT 417

  Fly   590 FNVKDITQVLEITVFDE-----------DRDHRVEFLGKLVIPLLRIKSGVKRWYTLKDKNLCVR 643
            :.|.|...|:.:.|||.           .:|.|:   ||:.|.|..:::  .|.||.....|.:.
plant   418 WEVFDPCTVVTVGVFDNCHLHGGEKIGGAKDSRI---GKVRIRLSTLET--DRVYTHSYPLLVLH 477

  Fly   644 AKGNSPQIQLELTVVWSEIRAVCRAL--------QPKEEKL-------IQQEAKFKRQLFLRNVN 693
            ..|.....::.|.|     |..|.:|        ||...|:       :.|....:.|.......
plant   478 PNGVKKMGEIHLAV-----RFTCSSLLNMMYMYSQPLLPKMHYIHPLTVSQLDNLRHQATQIVSM 537

  Fly   694 RL--------KEIIMDILDAARYVQSC-----------------------FE----WESPVRSSI 723
            ||        ||::..:||...::.|.                       ||    |::|:.:.:
plant   538 RLTRAEPPLRKEVVEYMLDVGSHMWSMRRSKANFFRIMGVLSGLIAVGKWFEQICNWKNPITTVL 602

  Fly   724 AFVFWIVACVYGDLETVPLVLLLIILKNWLVR--------LITGTTDA-AAHYDYEYDEDDDDDK 779
            ..:.:|:..:|.:|....:.|.|.::..|..|        :.|..:.| :||.| |.||:.|...
plant   603 IHLLFIILVLYPELILPTIFLYLFLIGIWYYRWRPRHPPHMDTRLSHADSAHPD-ELDEEFDTFP 666

  Fly   780 EKEEKKSIKERLQAIQEVSQTVQNTIGYLASLGESTINTFNFSVPELTWLAVVLLLGAILVLHFV 844
            .......::.|...::.::..:|..:|.||:.||...:..::..|..|.|.|:..|.|.::|:..
plant   667 TSRPSDIVRMRYDRLRSIAGRIQTVVGDLATQGERLQSLLSWRDPRATALFVLFCLIAAVILYVT 731

  Fly   845 PLRWLLLFWGL--MKFSRRLLRPNTIPNNELLDFLSRVP 881
            |.:.:.|..|:  ::..|...:..::|    |:|..|:|
plant   732 PFQVVALCIGIYALRHPRFRYKLPSVP----LNFFRRLP 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mctp	NP_001261078.1	C2A_MCTP_PRT	237..357	CDD:176007	37/129 (29%)
		C2B_MCTP_PRT	390..497	CDD:176022	28/136 (21%)
		C2C_MCTP_PRT	537..658	CDD:176023	37/134 (28%)
		PRT_C	<789..893	CDD:285560	23/95 (24%)
AT3G57880	NP_001327704.1	C2B_MCTP_PRT_plant	40..164	CDD:176024	38/133 (29%)
		C2C_MCTP_PRT_plant	202..351	CDD:175986	32/158 (20%)
		C2D_MCTP_PRT_plant	363..490	CDD:176025	35/131 (27%)
		PRT_C	618..773	CDD:337028	36/154 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I1886
OMA	1	1.010	-	-		QHG59961
OrthoDB	1	1.010	-	-		D234298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101057
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.880