DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mctp and Mctp1

DIOPT Version :9

Sequence 1:	NP_001261078.1	Gene:	Mctp / 37165	FlyBaseID:	FBgn0034389	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_006517525.3	Gene:	Mctp1 / 78771	MGIID:	1926021	Length:	987	Species:	Mus musculus

Alignment Length:	969	Identity:	358/969 - (36%)
Similarity:	516/969 - (53%)	Gaps:	167/969 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SGSTP------PLQISPHGSPSLQQSQRLGKHLSKSASELNGHDCHLSESPHISPKRAKSAVAQQ 86
            |.|.|      |..:.|.|:...:|...|.:.|.:                |:.|....|:.|..
Mouse    92 SSSQPNLCCSSPEPLEPGGAGRAEQGSTLRRRLRE----------------HLLPVAKGSSTATG 140

  Fly    87 LAGVSSGGVASGVGVLQKTHGFFNNLRHRWSRAKSKDRLGRKSPSDFLEESTDYAADYSSEGSSV 151
            ..||:..|                               ||         |.|.|...||..||:
Mouse   141 TGGVTPPG-------------------------------GR---------SPDSAPSSSSASSSL 165

  Fly   152 THSP---------RHRSTTIGGSPL------AREFRATAKMAQVIQRFGGSMEGRIDEHPENGSA 201
            :.||         |..||..||..:      :.....||.:.|:::......|      |..|.|
Mouse   166 SSSPQPPPRGDRVRDESTRRGGPGVHLCHQKSSSLPGTACLEQLLEPAPPPAE------PARGPA 224

  Fly   202 GCSPPELSTQQQLEALQANEL----RRKREAQLRQFVFFQLRVHLKSGSDLVAMDKNGLSDPYVK 262
              .|..|  |:.:|...:.::    ....:..|.....:||.:.|:.|..|.|.|:.|.||||||
Mouse   225 --EPQAL--QKDIERDCSQKISTVGNSNADVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVK 285

  Fly   263 FKVGGRLLHKSRTIHRDLNPVWDEVFIVPIEDPFQPIIVKVFDYDWGLQDDFMGSAKLDLTQLEL 327
            ||:|.:.:.:|:.||::|||||:|...|.|:...:|:.:||||||:||||||||||.||||||||
Mouse   286 FKIGRKEVFRSKIIHKNLNPVWEEKACVLIDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLEL 350

  Fly   328 GKAEDIHLQLCDSSGNGGSGLGEILINLTLWPRSQEDKEMH----------------------FQ 370
            .::.|:.|.|.|.. .....||.||:::.|.|:..|.:::.                      ::
Mouse   351 NRSTDVTLTLKDPH-YPDHDLGIILLSVILTPKEGEHRDVQSSIHSFLPWRICDIKTMLMRKSWK 414

  Fly   371 RNSK-LAE------------------------SSKRLKSQIWSSVVTILLVKAKDLPLAEDGSKL 410
            |:|| |:|                        |.:..||.:|..:|:|.|::.:||. |.|.:.|
Mouse   415 RSSKELSENEVFGFHFSVQSFFWRFQTQSLRLSDQHRKSHLWRGIVSITLIEGRDLK-AMDSNGL 478

  Fly   411 NDTHFKFRLGNEKYKSK---SSWTERWLEQFDLHLFDEDQN-LEIALWN-----RNTLYGKAIID 466
            :|.:.|||||::|||||   .:...:|.||||.||::|... ::|..|:     |:...|:..:|
Mouse   479 SDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGIMDITAWDKDAGKRDDFIGRCQVD 543

  Fly   467 LSVFQRENTHGIWKPLEDCPGEVHLMLTISGT-TALETISDLKA-FKEDPREAQLLRERYKFLRC 529
            ||...||.||.:...||:  ||.||:|.::.| :|...||||.. ..||.:|.:.:.:||..||.
Mouse   544 LSSLSREQTHKLELHLEE--GEGHLVLLVTLTASATVCISDLSVNSMEDQKEREEILKRYSPLRI 606

  Fly   530 LQNLRDVGHLTVKVFGATGLAAADIGGKSDPFCVLELGNARLQTQTEYKTLTPNWNKIFTFNVKD 594
            ..||:|||.|.|||..|.||.|||:.||||||||:||.|.||.|.|.||.|.|.|||:||||:||
Mouse   607 FNNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKD 671

  Fly   595 ITQVLEITVFDEDRDHRVEFLGKLVIPLLRIKSGVKRWYTLKDKNLCVRAKGNSPQIQLELTVVW 659
            |..|||:||:|||||...:|||::.||||.|::|.::.|.||:|.|....||   .|.||:.|::
Mouse   672 IHSVLEVTVYDEDRDRSADFLGRVAIPLLSIQNGEQKAYVLKNKQLTGPTKG---VIYLEIDVIF 733

  Fly   660 SEIRAVCRALQPKEEKLIQQEAKFKRQLFLRNVNRLKEIIMDILDAARYVQSCFEWESPVRSSIA 724
            :.::|..|.|.|||.|.|::|.:..:||.|||..|.|..::.:::||.||.|||:|:||.||..|
Mouse   734 NAVKASLRTLIPKERKYIEEENRLSKQLLLRNFIRTKRCVIVLVNAAYYVNSCFDWDSPPRSLAA 798

  Fly   725 FVFWIVACVYGDLETVPLVLLLIILKNWLVRLITG------TTDAAAHYDYEYDEDDDDDKEKEE 783
            ||.:::.....:|..:||:|||::..|:.: :|:|      .|......:.|.:|||.|||: .|
Mouse   799 FVLFLLIVWNFELYMIPLLLLLLLTWNYFL-IISGKDNRQRDTVVEDMLEDEEEEDDRDDKD-GE 861

  Fly   784 KKSIKERLQAIQEVSQTVQNTIGYLASLGESTINTFNFSVPELTWLAVVLLLGAILVLHFVPLRW 848
            ||....::.|||||..:|||.:..:|||||...||||::||.|:|||:|.|.....:|:|:|||:
Mouse   862 KKGFINKIYAIQEVCVSVQNILDEVASLGERIKNTFNWTVPFLSWLAIVALCVFTAILYFIPLRY 926

  Fly   849 LLLFWGLMKFSRRLLRPNTIPNNELLDFLSRVPDNEEINQYRELPPS---APTDQTRNN 904
            ::|.||:.||:::|..|..|.||||||||||||.:.::.||:||.|.   :|..:.:||
Mouse   927 IVLVWGINKFTKKLRSPYAIDNNELLDFLSRVPSDVQVVQYQELKPDHSHSPYKRKKNN 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mctp	NP_001261078.1	C2A_MCTP_PRT	237..357	CDD:176007	61/119 (51%)
		C2B_MCTP_PRT	390..497	CDD:176022	45/115 (39%)
		C2C_MCTP_PRT	537..658	CDD:176023	69/120 (58%)
		PRT_C	<789..893	CDD:285560	53/103 (51%)
Mctp1	XP_006517525.3	C2A_MCTP_PRT	260..381	CDD:176007	62/121 (51%)
		C2B_MCTP_PRT	459..574	CDD:176022	45/117 (38%)
		C2C_MCTP_PRT	614..732	CDD:176023	69/120 (58%)
		PRT_C	<875..960	CDD:337028	45/84 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833264
Domainoid	1	1.000	124	1.000	Domainoid score	I5514
eggNOG	1	0.900	-	-		E1_KOG1030
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75211
Inparanoid	1	1.050	548	1.000	Inparanoid score	I1141
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59961
OrthoDB	1	1.010	-	-		D139564at33208
OrthoFinder	1	1.000	-	-		FOG0002654
OrthoInspector	1	1.000	-	-		otm42334
orthoMCL	1	0.900	-	-		OOG6_101057
Panther	1	1.100	-	-	LDO	PTHR45911
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2311
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800