Protein Alignment Mctp and ESYT2

DIOPT Version :9

• Sequence 1: NP_001261078.1
• Gene: Mctp / 37165
• FlyBaseID: FBgn0034389
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: XP_024302614.1
• Gene: ESYT2 / 57488
• HGNCID: 22211
• Length: 868
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 127/574 - (22%)
• Similarity: 210/574 - (36%)
• Gaps: 202/574 - (35%)

  Fly   227 EAQLRQFVF----FQLRVHLKSGSDLVAMDK------NGLSDPYVKFKVGGRLLHKSRTIHRDLN 281
            |.|:.|..|    ..||:|.....||...|.      .|.||||...:||.::. :||.|..:|:
Human   344 EVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIF-QSRVIKENLS 407

  Fly   282 PVWDEVF-IVPIEDPFQPIIVKVFDYDWGLQDDFMGSAKLDLTQLELGKAED------------I 333
            |.|:||: .:..|.|.|.:.:::||.|.. :|||:||..:||.::|..:..|            :
Human   408 PKWNEVYEALVYEHPGQELEIELFDEDPD-KDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKL 471

  Fly   334 HLQL--CDSSGNGGSGLGEILINLTLWPRSQEDKEMHFQRNSKLAESSKRLKSQIWSSVVTILLV 396
            ||:|  .....| .|.|.::|.::      :.||:   |.|..|:           |:::.:.|.
Human   472 HLRLEWLTLMPN-ASNLDKVLTDI------KADKD---QANDGLS-----------SALLILYLD 515

  Fly   397 KAKDLPLA-EDGSKLNDTHFKFRLGNEKYKSKSSWTERWLEQFDLHLFDEDQNLEIALWNRNTLY 460
            .|::||:. :....:.:.:|.|.:.|.|.:             ||.:...|:..:.:|.|.....
Human   516 SARNLPIRYKTNEPVWEENFTFFIHNPKRQ-------------DLEVEVRDEQHQCSLGNLKVPL 567

  Fly   461 GKAII--DLSVFQR------------------------------ENTHG--IWKPLEDCPG-EVH 490
            .:.:.  |::|.||                              ::.|.  :.:|.....| :..
Human   568 SQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTS 632

  Fly   491 LMLTISGT-------TALETI----SDLKAFKE--DPREA------------------------- 517
            :...:||:       ||..|.    ||....:|  .|.||
Human   633 IKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVK 697

  Fly   518 ----------------QLLRERYKFLRCLQNLRDVGH------------------LTVKVFGATG 548
                            |.||:|   ||.|:|...:|.                  |.|.|.....
Human   698 EPTPSIASDISLPIATQELRQR---LRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRN 759

  Fly   549 LAAADIGGKSDPFCVLEL-----GNARLQTQTEYKTLTPNWNKIFTFNVKDITQV----LEITV- 603
            |.|....| |||:..:.|     .:.|.:|....|||.|.:::.|.|:| .:.:|    |::.|
Human   760 LIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSV-SLPEVQRRTLDVAVK 822

  Fly   604 -----FDEDRDHRVEFLGKLVIPLL--RIKSGVKRWYTLKDKNLCVRAKGNSPQ 650
                 ..:|:.    .|||:::.|.  .:..|..:||.|.:       .|..||
Human   823 NSGGFLSKDKG----LLGKVLVALASEELAKGWTQWYDLTE-------DGTRPQ 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mctp	NP_001261078.1	C2A_MCTP_PRT	237..357	CDD:176007	43/140 (31%)
		C2B_MCTP_PRT	390..497	CDD:176022	20/142 (14%)
		C2C_MCTP_PRT	537..658	CDD:176023	35/149 (23%)
		PRT_C	<789..893	CDD:285560
ESYT2	XP_024302614.1	SMP_LBD	163..342	CDD:293652
		C2A_C2C_Synaptotagmin_like	357..477	CDD:176037	39/121 (32%)
		C2B_Synaptotagmin-like	509..589	CDD:176015	17/92 (18%)
		C2C_KIAA1228	733..858	CDD:175996	30/130 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2311
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940