DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mctp and mctp2a

DIOPT Version :9

Sequence 1:	NP_001261078.1	Gene:	Mctp / 37165	FlyBaseID:	FBgn0034389	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_690870.6	Gene:	mctp2a / 562393	ZFINID:	ZDB-GENE-040724-63	Length:	927	Species:	Danio rerio

Alignment Length:	960	Identity:	312/960 - (32%)
Similarity:	487/960 - (50%)	Gaps:	146/960 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SGSTPPLQISPHGSPSLQ--------------QSQRLGKHLSKSASELNG-------------HD 65
            |.|.|.|:.:|....:||              .:..|| .:..:|||.:.             :.
Zfish    37 SMSVPDLRFNPRAMMALQDESSTPSQASAFFDNTDGLG-DIDDTASETSSVAFSERFSVADVPYV 100

  Fly    66 CHLSESPHISP----------KRAKSAVAQQLAGVSSGGVASGVGVLQKTHGFFNNLRHRWSR-A 119
            |..:.|...:|          ||.::.........|..||......||.|.|      |...| .
Zfish   101 CSPAPSERSAPVDFPVSAETDKRQRATTWYFEDSDSVTGVTPSSAELQMTAG------HAERRPT 159

  Fly   120 KSKDR----LGRKSPSDFLEESTDYAADYSSEGSSVTHSPRHRSTTIGGSPLAREFRATAKMAQV 180
            :|.|:    |||....|.:..|::..|.::.      |.|        .|||:.....:|:....
Zfish   160 ESSDKLVAALGRARALDDMSISSEEKAWHTE------HEP--------SSPLSMFVVGSAEYLDT 210

  Fly   181 IQRFGGSMEGRIDEHPENGSAGCSPPELSTQQQLEALQANELRRKREAQLRQFVFFQLRVHLKSG 245
            ........:  :.||..|.|.|     |:..|....||..:              :.|.::||.|
Zfish   211 PNETSDFDD--LSEHERNISGG-----LTESQSAAGLQKLQ--------------YLLTINLKEG 254

  Fly   246 SDLVAMDKNGLSDPYVKFKVGGRLLHKSRTIHRDLNPVWDEVFIVPIEDPFQPIIVKVFDYDWGL 310
            .:||..|::|.|||:||||:.|:.::||:.::::|||.|:|.|.:|:.|..|.:.:||:|.|. .
Zfish   255 RNLVVRDRSGTSDPFVKFKLDGKHIYKSKVVNKNLNPTWNESFSLPVRDLDQTLHLKVYDRDL-R 318

  Fly   311 QDDFMGSAKLDLTQLELGKAEDIHLQLCDSSGNGGSGLGEILINLTLWPRSQEDKEMHFQRNSKL 375
            .:|||||:...|::|||.:...:.|.|.|.:.. .|.:|.|:|...|..|.:..|     ||..|
Zfish   319 SNDFMGSSSFPLSKLELDRMVLMTLSLEDPNSE-ESDMGVIIIEACLSIREEPAK-----RNKWL 377

  Fly   376 ---------------AESSKRLKSQIWSSVVTILLVKAKDLPLAEDGSKLNDTHFKFRLGNEKYK 425
                           |:..:..|||:||.|.|::||:.:|:|....|    |.:.:||||:::.:
Zfish   378 LRRKGSFNKGQPISQAQFGRFTKSQVWSGVYTVILVEGQDMPDCGQG----DVYVRFRLGDQRVR 438

  Fly   426 SKS---SWTERWLEQFDLHLF-DEDQNLEIALW-----NRNTLYGKAIIDLS---VFQRE-NTHG 477
            |||   ....:|.|.||.:.| |..:||.:.:.     .....:|...||||   |.||: .|:
Zfish   439 SKSLCIKANPQWRESFDFNQFQDAQENLVVEVCCKRGRKSEECWGVLDIDLSRLPVNQRQLYTY- 502

  Fly   478 IWKPLEDCPGEVHLMLTISGTTALETISDLK-AFKEDPREAQLLRERYKFLRCLQNLRDVGHLTV 541
               .|:...|::..::|::..:. .:|||:: |..::|...:.:||:|:.:..|.:.::||.|.|
Zfish   503 ---ELDPQKGKLRFLVTLTPCSG-ASISDIQSAPLDNPNTFEKMREQYRPMNILGDFKNVGFLQV 563

  Fly   542 KVFGATGLAAADIGGKSDPFCVLELGNARLQTQTEYKTLTPNWNKIFTFNVKDITQVLEITVFDE 606
            |:..||.|.:.||.|||||||.|||||::|||.|..|||.|.|....||.::||..||.:||:.|
Zfish   564 KLIRATDLPSTDISGKSDPFCTLELGNSKLQTHTICKTLNPEWRTALTFPIRDIHDVLVLTVYHE 628

  Fly   607 DRDHRVEFLGKLVIPLLRIKSGVKRWYTLKDKNLCVRAKGNSPQIQLELTVVWSEIRAVCRALQP 671
            |.|...:||||:.||||.|.:|.:....||..||   ::.|...|.|||.|:::.|:|..:..||
Zfish   629 DGDKAPDFLGKVAIPLLTISNGQQITRMLKTNNL---SRANKGSITLELKVLYNPIKAGIKTFQP 690

  Fly   672 KEEKLIQQEAKFKRQLFLRNVNRLKEIIMDILDAARYVQSCFEWESPVRSSIAFVFWIVACVYGD 736
            ||....:...||.::|..||:.|:::|.|.||...:|::|||.||:..||..||:.::||....:
Zfish   691 KETMFAEDNPKFNKKLLARNIYRVRKISMAILYTLQYIKSCFHWENTQRSITAFLIFVVAVWLWE 755

  Fly   737 LETVPLVLLLIILKNWLVRLITGTTDAAAHYDYEYD-----EDDDDDKEKEEKKSIKERLQAIQE 796
            |..:||.|||:|..|:.     ..|...|.|..:.:     ||:|:|:::.||:.:.|::..:||
Zfish   756 LFMLPLFLLLLIGWNYF-----HITPGMASYSQDLEHMSVAEDEDEDEKESEKRGLMEKIHMVQE 815

  Fly   797 VSQTVQNTIGYLASLGESTINTFNFSVPELTWLAVVLLLGAILVLHFVPLRWLLLFWGLMKFSRR 861
            :..|||:|:..:|.:||...||||:|||.|:.||.::||.|.:.|:::|||:::|.||:.||:::
Zfish   816 IVLTVQSTLDEVACIGERVKNTFNWSVPFLSLLACLVLLVATVGLYYIPLRYIVLLWGVNKFTKK 880

  Fly   862 LLRPNTIPNNELLDFLSRVPDNEEINQYRELPPSAPTDQTRNNPKKKLKG 911
            |..|..|.|||:||||.|||.:.:..||.||    ..:.....|.||.:|
Zfish   881 LFNPYAIDNNEMLDFLKRVPSDVQKVQYSEL----RAELGNQGPVKKKRG 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mctp	NP_001261078.1	C2A_MCTP_PRT	237..357	CDD:176007	47/119 (39%)
		C2B_MCTP_PRT	390..497	CDD:176022	35/119 (29%)
		C2C_MCTP_PRT	537..658	CDD:176023	60/120 (50%)
		PRT_C	<789..893	CDD:285560	48/103 (47%)
mctp2a	XP_690870.6	C2A_MCTP_PRT	246..365	CDD:176007	47/120 (39%)
		C2B_MCTP_PRT	407..519	CDD:176022	35/119 (29%)
		C2C_MCTP_PRT	559..677	CDD:176023	60/120 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575962
Domainoid	1	1.000	118	1.000	Domainoid score	I5807
eggNOG	1	0.900	-	-		E1_KOG1030
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59961
OrthoDB	1	1.010	-	-		D139564at33208
OrthoFinder	1	1.000	-	-		FOG0002654
OrthoInspector	1	1.000	-	-		otm24820
orthoMCL	1	0.900	-	-		OOG6_101057
Panther	1	1.100	-	-	O	PTHR45911
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.720