DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mctp and MCTP2

DIOPT Version :9

Sequence 1:	NP_001261078.1	Gene:	Mctp / 37165	FlyBaseID:	FBgn0034389	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001371930.1	Gene:	MCTP2 / 55784	HGNCID:	25636	Length:	878	Species:	Homo sapiens

Alignment Length:	924	Identity:	321/924 - (34%)
Similarity:	500/924 - (54%)	Gaps:	106/924 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VELDQQQQPGSSSTVSGSTPPLQI---------SPHGSPSLQQSQRLGKHLSKSASELNGHDCHL 68
            ::||   :|....::...|.||.|         :|...|.|:....|.:.||.|..:|...:...
Human     1 MDLD---KPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEALA 62

  Fly    69 SES-PHISPKRAKSAVAQQLAGVSSGGVASGVGVLQKTHGFFNNLRHRWSRAKSKDRLGRKSPSD 132
            .|. |:..|:.:.::|...|:                |.|.|                 .||.|.
Human    63 PEGRPYSGPQSSYTSVPSSLS----------------TAGIF-----------------PKSSSS 94

  Fly   133 FLEESTDYAADYSSEGSSVTHSPRHRSTTIGGSPLAREFRATAKMAQVIQRFGGSMEGRIDEHPE 197
            .|::|.: ..|:|.|.:|..|.....|.....||..|. |.::.....:|:  .|:.|...|.||
Human    95 SLKQSEE-ELDWSQEEASHLHVVETDSEEAYASPAERR-RVSSNGIFDLQK--TSLGGDAPEEPE 155

  Fly   198 NGSAGCSPPELS---TQQQLEALQANELRRKREAQLRQFVFFQLRVHLKSGSDLVAMDKNGLSDP 259
            .   .|...:|:   |.|..|............:.|.....:.|.:|||.|.:||..|:.|.|||
Human   156 K---LCGSSDLNASMTSQHFEEQSVPGEASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDP 217

  Fly   260 YVKFKVGGRLLHKSRTIHRDLNPVWDEVFIVPIEDPFQPIIVKVFDYDWGLQDDFMGSAKLDLTQ 324
            |||||:.|:.|:||:.|:::|||||||:.::||:...|.:.|||:|.|. ...||||||.:.|:.
Human   218 YVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLPIQSLDQKLRVKVYDRDL-TTSDFMGSAFVILSD 281

  Fly   325 LELGKAEDIHLQLCDSSGNGGSGLGEILINLTLWPRSQEDKEMHFQ-------------RNSKLA 376
            |||.:..: |:...:...:....:|.|::||.|..:..:.|...:.             ||.:|:
Human   282 LELNRTTE-HILKLEDPNSLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLS 345

  Fly   377 ESSKRLKSQIWSSVVTILLVKAKDLPLAEDGSKLNDTHFKFRLGNEKYKSKS---SWTERWLEQF 438
            ||.|  |:|:|:.:::|.|::.|::    .|..:.:...:.:||:::||||:   |...:|.|||
Human   346 ESLK--KNQLWNGIISITLLEGKNV----SGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQF 404

  Fly   439 DLHLFDEDQN-LEIALWNRNT-----LYGKAIIDLSVFQRENTHGIWKPLEDCPGEVHLMLTISG 497
            |.|.|.:... |:|.:|.::.     ..|...:|:|....:..:.:..||:.|.|.:.:::|::.
Human   405 DFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTP 469

  Fly   498 TTALETISDLKAFK-EDPREAQLLRERYKFLRCLQN----LRDVGHLTVKVFGATGLAAADIGGK 557
            ...: ::|||.... .|..|.:.:.:||    ||||    ::|||.|.|||..|..|.|||..||
Human   470 CAGV-SVSDLCVCPLADLSERKQITQRY----CLQNSLKDVKDVGILQVKVLKAADLLAADFSGK 529

  Fly   558 SDPFCVLELGNARLQTQTEYKTLTPNWNKIFTFNVKDITQVLEITVFDEDRDHRVEFLGKLVIPL 622
            |||||:|||||.||||.|.||.|.|.|||:|||.:|||..|||:||||||.|...:||||:.|||
Human   530 SDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPL 594

  Fly   623 LRIKSGVKRWYTLKDKNLCVRAKGNSPQIQLELTVVWSEIRAVCRALQPKEEKLIQQEAKFKRQL 687
            |.|:.|....|.||:|:|....||   .|.||:.::::.::|..|...|:|::.::...|..:::
Human   595 LSIRDGQPNCYVLKNKDLEQAFKG---VIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKI 656

  Fly   688 FLRNVNRLKEIIMDILDAARYVQSCFEWESPVRSSIAFVFWIVACVYGDLETVPLVLLLIILKNW 752
            ..|:|:|:|.|.|.|.:..::::|||:|||.:||:|||..:::.....:|..:||.||||.:.|:
Human   657 LSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYNF 721

  Fly   753 LVRLITGTT----DAAAHYDYEYDEDDDDDKEKEEKKSIKERLQAIQEVSQTVQNTIGYLASLGE 813
             :|.:.|..    |:....|.: ||:|:|||| .|||.:.||:..:|::..||||.:..:||.||
Human   722 -IRPVKGKVSSIQDSQESTDID-DEEDEDDKE-SEKKGLIERIYMVQDIVSTVQNVLEEIASFGE 783

  Fly   814 STINTFNFSVPELTWLAVVLLLGAILVLHFVPLRWLLLFWGLMKFSRRLLRPNTIPNNELLDFLS 878
            ...||||::||.|:.||.::|..|.::|:|:|||:::|.||:.||:::|..|.:|.|||||||||
Human   784 RIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDNNELLDFLS 848

  Fly   879 RVPDNEEINQYREL 892
            |||.:.:..||.||
Human   849 RVPSDVQKVQYAEL 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mctp	NP_001261078.1	C2A_MCTP_PRT	237..357	CDD:176007	52/119 (44%)
		C2B_MCTP_PRT	390..497	CDD:176022	29/115 (25%)
		C2C_MCTP_PRT	537..658	CDD:176023	70/120 (58%)
		PRT_C	<789..893	CDD:285560	51/104 (49%)
MCTP2	NP_001371930.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..46		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..163		30/142 (21%)
		C2A_MCTP_PRT	195..314	CDD:176007	52/120 (43%)
		C2B_MCTP_PRT	357..469	CDD:176022	29/115 (25%)
		C2C_MCTP_PRT	509..627	CDD:176023	70/120 (58%)
		PRT_C	<771..>824	CDD:337028	24/52 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143113
Domainoid	1	1.000	126	1.000	Domainoid score	I5431
eggNOG	1	0.900	-	-		E1_KOG1030
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	530	1.000	Inparanoid score	I1221
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59961
OrthoDB	1	1.010	-	-		D139564at33208
OrthoFinder	1	1.000	-	-		FOG0002654
OrthoInspector	1	1.000	-	-		otm40267
orthoMCL	1	0.900	-	-		OOG6_101057
Panther	1	1.100	-	-	O	PTHR45911
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770