DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mctp and Mctp1

DIOPT Version :9

Sequence 1:	NP_001261078.1	Gene:	Mctp / 37165	FlyBaseID:	FBgn0034389	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_038958080.1	Gene:	Mctp1 / 309928	RGDID:	1305199	Length:	962	Species:	Rattus norvegicus

Alignment Length:	938	Identity:	353/938 - (37%)
Similarity:	513/938 - (54%)	Gaps:	126/938 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SGSTP------PLQISPHGSPSLQQSQRLGKHLSKSASELNGHDCHLSESPHISPKRAKSAVAQQ 86
            |.|.|      |..:.|.|:...:|...|.:.|.:                |:.|....|:.|..
  Rat    88 SSSQPNLCCSSPEPLEPGGAGRAEQGSTLRRRLRE----------------HLLPVAKGSSTAAG 136

  Fly    87 LAGVSSGGVASGVGVLQKTHGFFNNLRHRWSRAKSKDRLGRKSPSDFLEEST------DYAADYS 145
            ..||:..|                        .:|.|.....|.|..|..|.      |...|..
  Rat   137 TVGVTPPG------------------------GRSPDSAPSSSASSSLSSSPQPPPRGDRIRDEG 177

  Fly   146 S-EGSSVTHSPRHRSTTIGGSPLAREFRATAKMAQVIQRFGGSME-GRIDEHPENGSAGCSPPEL 208
            : .||...|....:|:::.|         ||.:.|:::......| .|....|::...|   .||
  Rat   178 TRRGSPEAHLCHQKSSSLPG---------TACLEQLLEPAPPPAEPARRPAEPQSLQKG---EEL 230

  Fly   209 STQQQLEALQANELRRKREAQLRQFVFFQLRVHLKSGSDLVAMDKNGLSDPYVKFKVGGRLLHKS 273
            ...|::..::.:    ..:..|.....:||.:.|:.|..|.|.|:.|.||||||||:|.:.:.:|
  Rat   231 DCSQKINPVETS----NADVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGRKEVFRS 291

  Fly   274 RTIHRDLNPVWDEVFIVPIEDPFQPIIVKVFDYDWGLQDDFMGSAKLDLTQLELGKAEDIHLQLC 338
            :.||::|||||:|...|.|:...:|:.:||||||:||||||||||.||||||||.:..|:.|.|.
  Rat   292 KIIHKNLNPVWEEKACVLIDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLK 356

  Fly   339 DSSGNGGSGLGEILINLTLWPRSQEDKEMH----------------------FQRNSKLAESSKR 381
            |.. .....||.||:::.|.|:..|.:::.                      ::|:||....|.|
  Rat   357 DPH-YPDHDLGIILLSVILTPKEGEPRDVQSSIHSFLHWRICDIKTMLMRKSWKRSSKFQTQSLR 420

  Fly   382 L-----KSQIWSSVVTILLVKAKDLPLAEDGSKLNDTHFKFRLGNEKYKSK---SSWTERWLEQF 438
            |     ||.:|..:|:|.|::.:||. |.|.:.|:|.:.|||||::|||||   .:...:|.|||
  Rat   421 LSDQHRKSHLWRGIVSITLIEGRDLK-AMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQF 484

  Fly   439 DLHLFDEDQN-LEIALWN-----RNTLYGKAIIDLSVFQRENTHGIWKPLEDCPGEVHLMLTISG 497
            |.||::|... ::|..|:     |:...|:..:|||...||.||.:...||:  ||.||:|.::.
  Rat   485 DFHLYEERGGVMDITAWDKDAGKRDDFIGRCQVDLSSLSREQTHKLELQLEE--GEGHLVLLVTL 547

  Fly   498 T-TALETISDLKA-FKEDPREAQLLRERYKFLRCLQNLRDVGHLTVKVFGATGLAAADIGGKSDP 560
            | :|..:||||.. ..||.:|.:.:.:||..||...|::|||.|.|||..|.||.|||:.|||||
  Rat   548 TASATVSISDLSVNSMEDHKEREEILKRYSPLRIFNNIKDVGFLQVKVIRAEGLMAADVTGKSDP 612

  Fly   561 FCVLELGNARLQTQTEYKTLTPNWNKIFTFNVKDITQVLEITVFDEDRDHRVEFLGKLVIPLLRI 625
            |||:||.|.||.|.|.||.|.|.|||:||||:|||..|||:||:|||||...:|||::.||||.|
  Rat   613 FCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGRVAIPLLSI 677

  Fly   626 KSGVKRWYTLKDKNLCVRAKGNSPQIQLELTVVWSEIRAVCRALQPKEEKLIQQEAKFKRQLFLR 690
            ::|.::.|.||:|.|....||   .|.||:.|:::.::|..|.|.|||.|.|::|.:..:||.||
  Rat   678 QNGEQKAYVLKNKQLTGPTKG---VIHLEIDVIFNAVKASLRTLIPKERKYIEEENRLSKQLLLR 739

  Fly   691 NVNRLKEIIMDILDAARYVQSCFEWESPVRSSIAFVFWIVACVYGDLETVPLVLLLIILKNWLVR 755
            |..|.|..:|.:::||.||.|||:|:||.||..|||.:::.....:|..:||:|||::..|:.:
  Rat   740 NFIRTKRCVMVLVNAAYYVNSCFDWDSPPRSLAAFVLFLLVVWNFELYMIPLLLLLLLTWNYFL- 803

  Fly   756 LITG------TTDAAAHYDYEYDEDDDDDKEKEEKKSIKERLQAIQEVSQTVQNTIGYLASLGES 814
            :|:|      .|......:.|.:|||.|||: .|||....::.|||||..:|||.:...|||||.
  Rat   804 IISGKDNRQRDTVVEDMLEDEEEEDDRDDKD-GEKKGFINKIYAIQEVCVSVQNILDEAASLGER 867

  Fly   815 TINTFNFSVPELTWLAVVLLLGAILVLHFVPLRWLLLFWGLMKFSRRLLRPNTIPNNELLDFLSR 879
            ..||||::||.|:|||::.|.....:|:|:|||:::|.||:.||:::|..|..|.||||||||||
  Rat   868 VKNTFNWTVPFLSWLAIIALCVFTAILYFIPLRYIVLVWGINKFTKKLRSPYAIDNNELLDFLSR 932

  Fly   880 VPDNEEINQYRELPPS---APTDQTRNN 904
            ||.:.::.||:||.|.   :|..:.:||
  Rat   933 VPSDVQVVQYQELKPDHSHSPYKRKKNN 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mctp	NP_001261078.1	C2A_MCTP_PRT	237..357	CDD:176007	61/119 (51%)
		C2B_MCTP_PRT	390..497	CDD:176022	45/115 (39%)
		C2C_MCTP_PRT	537..658	CDD:176023	69/120 (58%)
		PRT_C	<789..893	CDD:285560	52/103 (50%)
Mctp1	XP_038958080.1	C2A_MCTP_PRT	255..376	CDD:176007	62/121 (51%)
		C2B_MCTP_PRT	434..549	CDD:176022	45/117 (38%)
		C2C_MCTP_PRT	589..707	CDD:176023	69/120 (58%)
		PRT_C	<850..935	CDD:337028	44/84 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336827
Domainoid	1	1.000	124	1.000	Domainoid score	I5387
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75211
Inparanoid	1	1.050	549	1.000	Inparanoid score	I1103
OMA	1	1.010	-	-		QHG59961
OrthoDB	1	1.010	-	-		D139564at33208
OrthoFinder	1	1.000	-	-		FOG0002654
OrthoInspector	1	1.000	-	-		otm44393
orthoMCL	1	0.900	-	-		OOG6_101057
Panther	1	1.100	-	-	LDO	PTHR45911
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910