DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mctp and Mctp2

DIOPT Version :9

Sequence 1:	NP_001261078.1	Gene:	Mctp / 37165	FlyBaseID:	FBgn0034389	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001178554.1	Gene:	Mctp2 / 308742	RGDID:	1562967	Length:	872	Species:	Rattus norvegicus

Alignment Length:	941	Identity:	328/941 - (34%)
Similarity:	510/941 - (54%)	Gaps:	117/941 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VELDQQQQPGSSSTVSGSTPPLQI---------SPHGSPSLQQSQRLGKHLSKSASELNGHDCHL 68
            ::||   :|....::...|.||.|         ||.....|:....|.:.||.|..:|...:..:
  Rat     1 MDLD---KPSVWGSLKQRTRPLLINLSKKKAKKSPSKPLDLRVQHHLDRRLSLSVPDLLEAEALV 62

  Fly    69 SES-PHISPKRAKSAVAQQLAGVSSGGVASGVGVLQKTHGFFNNLRHRWSRAKSKDRLGRKSPSD 132
            .|. |:..|:.:..:|...|   |:.|:..                              ||.|.
  Rat    63 PEGRPYSGPQSSYISVPNSL---STAGIVP------------------------------KSSSS 94

  Fly   133 FLEESTDYAADYSSEGSSVTHSPRHRSTTIGGSPLAREFRATAKMAQVIQRFGGSMEGRIDEHPE 197
            .|::|.: ..::|.|.:|........|..|..|| |.|::|.::        .|....:..|.||
  Rat    95 SLKQSEE-ELEWSQEEASHVPGVDTDSEEIYASP-AEEWQAFSQ--------SGLDLHKAPEEPE 149

  Fly   198 --NGSAGCSPPELSTQQQLEALQANELRRKREAQLRQFVFFQLRVHLKSGSDLVAMDKNGLSDPY 260
              :||...: ..:|:||..|.|...|...........|.:. |.:|||.|.:||..|:.|.||||
  Rat   150 KTHGSDDLN-ASMSSQQFEEQLTLGEASDCVSHLPSPFAYL-LTIHLKEGRNLVVRDRCGTSDPY 212

  Fly   261 VKFKVGGRLLHKSRTIHRDLNPVWDEVFIVPIEDPFQPIIVKVFDYDWGLQDDFMGSAKLDLTQL 325
            ||||:.|:.|:||:.|:::|||:|||:.::||:...|.:.|||:|.|. .:.||||||.:.|..|
  Rat   213 VKFKLNGKTLYKSKVIYKNLNPIWDEIVVLPIQSLDQKLRVKVYDRDL-TKSDFMGSAFVVLRDL 276

  Fly   326 ELGKAEDIHLQLCDSSGNGGSGLGEILINLTLWPRSQEDKEMHFQ-------------RNSKLAE 377
            ||.:..: |:...:...:....:|.|::||.|..:..:.|...:.             ||.:|:|
  Rat   277 ELNRTTE-HILKLEDPNSLEDDMGVIVLNLNLVVKQGDFKRQRWSNRKRLSASKSSLIRNLRLSE 340

  Fly   378 SSKRLKSQIWSSVVTILLVKAKDLPLAEDGSKLNDTHFKFRLGNEKYKSKS---SWTERWLEQFD 439
            |.:  |:|:|:.:::|.|::.|::    .|..:.:...:.:||.::||||:   |...:|.||||
  Rat   341 SLR--KNQLWNGIISITLLEGKNV----SGGNMTEMFVQLKLGEQRYKSKTLCKSENPQWQEQFD 399

  Fly   440 LHLFDEDQN-LEIALWNRNT-----LYGKAIIDLSVFQRENTHGIWKPLEDCPGEVHLMLTISGT 498
            .|.|.:... |:|.:|.::.     ..|...:|:|....:..:.:..|||.|.|.:.:::|::..
  Rat   400 FHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQDNCLELPLESCQGALLMLITLTPC 464

  Fly   499 TALETISDLKAFK-EDPREAQLLRERYKFLRCLQNLRDVGHLTVKVFGATGLAAADIGGKSDPFC 562
            ||: :||||.... |||.|.||:.:||.....|::::|||.|.|||..|..|.|||..|||||||
  Rat   465 TAV-SISDLCVCPLEDPSERQLISQRYALQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFC 528

  Fly   563 VLELGNARLQTQTEYKTLTPNWNKIFTFNVKDITQVLEITVFDEDRDHRVEFLGKLVIPLLRIKS 627
            :|||||.||||.|.||.|.|.|||:|||.:|||..|||:||||||.|...:||||:.||||.|:.
  Rat   529 LLELGNDRLQTHTIYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKAPDFLGKVAIPLLSIRD 593

  Fly   628 GVKRWYTLKDKNLCVRAKGNSPQIQLELTVVWSEIRAVCRALQPKEEKLIQQEAKFKRQLFLRNV 692
            |....|.||:|:|....||   .|.|||.::::.::|..|...|:|::.::...|..:::..|:|
  Rat   594 GQPNCYVLKNKDLEQAFKG---LIYLELDLIYNPVKASIRTFSPREKRFVEDSRKLSKKILSRDV 655

  Fly   693 NRLKEIIMDILDAARYVQSCFEWESPVRSSIAFVFWIVACVYGDLETVPLVLLLIILKNWLVRLI 757
            :|:|.:.|.|.:..::.:|||:|||.:||::|||.::|.....:|..:||.:||:.|.|:| |.:
  Rat   656 DRVKRLTMAIWNTIQFFKSCFQWESTLRSTVAFVVFLVTVWNFELYMIPLAMLLLFLYNFL-RPM 719

  Fly   758 TG----TTDAAAHYDYEYDEDDDDDKEKEEKKSIKERLQAIQEVSQTVQNTIGYLASLGESTINT 818
            .|    |.|:....|.|  |::.:::::.|||.|.||:..:|::..||||.:..:||.||...||
  Rat   720 KGKASSTQDSQDSTDIE--EEEKEEEKESEKKGIIERIYMVQDIVSTVQNILEEVASFGERIKNT 782

  Fly   819 FNFSVPELTWLAVVLLLGAILVLHFVPLRWLLLFWGLMKFSRRLLRPNTIPNNELLDFLSRVPDN 883
            ||::||.|:.||.::|..|.:||:|:|||:::|.||:.||:::|..|.:|.||||||||||||.:
  Rat   783 FNWTVPFLSLLACLILAIATVVLYFIPLRYIILLWGINKFTKKLRNPYSIDNNELLDFLSRVPSD 847

  Fly   884 EEINQYRELPPSAPTDQTRNNPKKKLKGSXS 914
            .:..||.||               ||.||.|
  Rat   848 IQKVQYAEL---------------KLCGSHS 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mctp	NP_001261078.1	C2A_MCTP_PRT	237..357	CDD:176007	51/119 (43%)
		C2B_MCTP_PRT	390..497	CDD:176022	30/115 (26%)
		C2C_MCTP_PRT	537..658	CDD:176023	71/120 (59%)
		PRT_C	<789..893	CDD:285560	51/103 (50%)
Mctp2	NP_001178554.1	C2A_MCTP_PRT	189..308	CDD:176007	51/121 (42%)
		C2B_MCTP_PRT	351..463	CDD:176022	30/115 (26%)
		C2C_MCTP_PRT	503..621	CDD:176023	71/120 (59%)
		PRT_C	<765..>818	CDD:285560	25/52 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336826
Domainoid	1	1.000	124	1.000	Domainoid score	I5387
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	549	1.000	Inparanoid score	I1103
OMA	1	1.010	-	-		QHG59961
OrthoDB	1	1.010	-	-		D139564at33208
OrthoFinder	1	1.000	-	-		FOG0002654
OrthoInspector	1	1.000	-	-		otm44393
orthoMCL	1	0.900	-	-		OOG6_101057
Panther	1	1.100	-	-	O	PTHR45911
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870