DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mctp and SPCC962.01

DIOPT Version :9

Sequence 1:	NP_001261078.1	Gene:	Mctp / 37165	FlyBaseID:	FBgn0034389	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_587865.1	Gene:	SPCC962.01 / 2539288	PomBaseID:	SPCC962.01	Length:	1429	Species:	Schizosaccharomyces pombe

Alignment Length:	481	Identity:	104/481 - (21%)
Similarity:	193/481 - (40%)	Gaps:	90/481 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 LRVHLKSGSDLVAMD-KNGLSDPYVKFKVGGRLLHKSRTIH--RDLNPVWDEVFIVPIEDPFQPI 299
            :|:.:...:|||.:: ....||||.:..||..::  :||::  .:|||:|:|:..|||....:.|
pombe   759 MRLSVIKANDLVNVELPTRKSDPYARVIVGNSVV--ARTVYTPNNLNPIWNEILYVPIMADTKTI 821

  Fly   300 IVKVFDYDWGLQDDFMGSAKLD---------------LTQLELGKAEDIHLQLCDSSGNGGSGLG 349
            .::..||:....|..:|.|.::               |.....|.:|...|.|  :|..|.|..|
pombe   822 DLEAMDYEESGNDRSLGYASINVQKYIRNAKRLDRSALASTVFGTSEVNALTL--TSRKGQSVRG 884

  Fly   350 EILINLTLWPRSQEDKEMHFQRNSKLAESS---------KRLKSQIWSSVVTILLV-KAKDLP-- 402
            .|.:|....|..:.:.:...:::|:..:|:         ....:...||:.:::.| :|...|
pombe   885 TISVNCDYRPCLRLNTDNSSKQSSENVQSATDPTTPAKDNSTSNAETSSITSVISVNEALQYPSG 949

  Fly   403 ---LAEDGSKLNDTHFKFRLGNEK----------YKSKSSWTERWLEQFDLHLFDEDQNLE--IA 452
               ::...:.|.|.....|:..:.          .|:|   |.|| ..|.:.:..|.|..|  ..
pombe   950 FALISIVSADLQDVGVDLRVFTDNAAFPFITTPIAKTK---TPRW-SSFGISMVRELQFSETTFQ 1010

  Fly   453 LWNRNTLYGKAIIDLSVFQRE-NTHGIWKPLE-DCPGE----VHLMLTISGTTALETISDLKAFK 511
            |.:......|.:.:.||...: .:..:.:|.. :.||.    .|:.|:|:......|::.::::.
pombe  1011 LTDGAKKDPKVVCEHSVKTLDLVSEALGRPYSVEIPGSNGQLNHVRLSITYMPVPMTLNPMESYI 1075

  Fly   512 EDPREAQLLRERYKFLRCLQNLRDVGHLTVKVFGATGLAAADIGGKSDPFCVLEL-GNARLQTQT 575
            ..                       |.|...:.....|...|| ..||||.||:| |.:..:::.
pombe  1076 NS-----------------------GSLHFMLQDGQNLPIGDI-RSSDPFVVLKLNGESAFKSKV 1116

  Fly   576 EYKTLTPNWNKIFTFNVKD-ITQVLEITVFDEDRDHRVEFLGKLVIPLLRIKSGVKRWYTLKDKN 639
            ..|.|.|.||:.....|:: :..|||:..:|.|...:.:.||...|.||.::..|:...::|
pombe  1117 IKKNLNPVWNEEADIVVQNRVLDVLELVCYDWDMGEKPDVLGTSNIDLLSLEPNVESQQSIK--- 1178

  Fly   640 LCVRAKGNSPQIQLELTVVWSEIRAV 665
              :.:|..:....|.....|...:||
pombe  1179 --LDSKTGTINASLRFVPGWHRRKAV 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mctp	NP_001261078.1	C2A_MCTP_PRT	237..357	CDD:176007	37/136 (27%)
		C2B_MCTP_PRT	390..497	CDD:176022	25/130 (19%)
		C2C_MCTP_PRT	537..658	CDD:176023	33/122 (27%)
		PRT_C	<789..893	CDD:285560
SPCC962.01	NP_587865.1	COG5038	45..1275	CDD:227371	104/481 (22%)
		C2	483..604	CDD:301316
		C2C_Tricalbin-like	757..879	CDD:176010	32/123 (26%)
		C2	1086..1194	CDD:301316	31/113 (27%)
		C2	1332..>1373	CDD:301316
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2311
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940