DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mctp and Mctp2

DIOPT Version :9

Sequence 1:	NP_001261078.1	Gene:	Mctp / 37165	FlyBaseID:	FBgn0034389	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001019874.1	Gene:	Mctp2 / 244049	MGIID:	2685335	Length:	878	Species:	Mus musculus

Alignment Length:	954	Identity:	326/954 - (34%)
Similarity:	507/954 - (53%)	Gaps:	137/954 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VELDQQQQPGSSSTVSGSTPPLQI---------SPHGSPSLQQSQRLGKHLSKSASELNGHDCHL 68
            ::||   :|....::...|.||.|         ||.....|:....|.:.||.|..:|...:...
Mouse     1 MDLD---KPSVWGSLKQRTRPLLINLSKKKAKKSPSKPLDLRVQHHLDRRLSLSVPDLLEAEALA 62

  Fly    69 SES-PHISPKRAKSAVAQQLAGVSSGGVASGVGVLQKTHGFFNNLRHRWSRAKSKDRLGRKSPSD 132
            .|. |:..|:.:..:|...|   |:.|:..                              ||.|.
Mouse    63 PEGRPYSGPQSSYISVPNSL---STAGIVP------------------------------KSSSS 94

  Fly   133 FLEESTDYAADYSSEGSSVTHSPRHRSTTIGGSPLAREFRATAKMAQVIQRFGGSMEGRIDEHPE 197
            .|::|.: ..|:|.|.:|..|.....|..|..|| |.|::|.::.|             :|.|
Mouse    95 SLKQSEE-ELDWSQEEASHVHGVDTDSEEIYASP-AEEWQAFSQSA-------------LDLH-- 142

  Fly   198 NGSAGCSPPE-------------LSTQQQLEALQANELRRKRE--AQLRQFVFFQLRVHLKSGSD 247
            ..|.|...||             ..|.|..|  :.:.|....:  :.|.....:.|.:|||.|.:
Mouse   143 KPSLGRDAPEEHDKTHGNDDLNASMTSQHFE--EESTLGEASDCVSHLPSPFAYLLTIHLKEGRN 205

  Fly   248 LVAMDKNGLSDPYVKFKVGGRLLHKSRTIHRDLNPVWDEVFIVPIEDPFQPIIVKVFDYDWGLQD 312
            ||..|:.|.||||||||:.|:.|:||:.|:::|||:|||:.::||:...|.:.|||:|.|. .:.
Mouse   206 LVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPIWDEIVVLPIQSLDQKLRVKVYDRDL-TKS 269

  Fly   313 DFMGSAKLDLTQLELGKAEDIHLQLCDSSGNGGSGLGEILINLTLWPRSQEDKEMHFQ------- 370
            ||||||.:.|..|||.:..: |:...:...:....:|.|::||.|..:..:.|...:.
Mouse   270 DFMGSAFVVLRDLELNRTTE-HILKLEDPNSLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSA 333

  Fly   371 ------RNSKLAESSKRLKSQIWSSVVTILLVKAKDLPLAEDGSKLNDTHFKFRLGNEKYKSKS- 428
                  ||.:|:||.:  |:|:|:.:::|.|::.|::    .|..:.:...:.:||.::||||:
Mouse   334 SKSSLIRNLRLSESLR--KNQLWNGIISITLLEGKNV----SGGNMTEMFVQLKLGEQRYKSKTL 392

  Fly   429 --SWTERWLEQFDLHLFDEDQN-LEIALWNRNT-----LYGKAIIDLSVFQRENTHGIWKPLEDC 485
              |...:|.||||.|.|.:... |:|.:|.:::     ..|...:|:|....:..:.:..|||.|
Mouse   393 CKSANPQWQEQFDFHYFSDRMGILDIEVWGKDSKKHEERLGTCKVDISALPLKQDNCLELPLESC 457

  Fly   486 PGEVHLMLTISGTTALETISDLKAFK-EDPREAQLLRERYKFLRCLQNLRDVGHLTVKVFGATGL 549
            .|.:.:::|::..|.: :||||.... |||.|.|.:.:||.|...|::::|||.|.|||..|:.|
Mouse   458 QGALLMLITLTPCTGV-SISDLCVCPFEDPSERQQISQRYAFQNSLKDVKDVGILQVKVLKASDL 521

  Fly   550 AAADIGGKSDPFCVLELGNARLQTQTEYKTLTPNWNKIFTFNVKDITQVLEITVFDEDRDHRVEF 614
            .|||..|||||||:|||||.||||.|.||.|.|.|||:|||.:|||..|||:||||||.|...:|
Mouse   522 LAADFSGKSDPFCLLELGNDRLQTHTIYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKAPDF 586

  Fly   615 LGKLVIPLLRIKSGVKRWYTLKDKNLCVRAKGNSPQIQLELTVVWSEIRAVCRALQPKEEKLIQQ 679
            |||:.||||.|:.|....|.||:|:|....||   .|.|||.::::.::|..|...|:|::.::.
Mouse   587 LGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKG---LIYLELDLIYNPVKASIRTFTPREKRFVED 648

  Fly   680 EAKFKRQLFLRNVNRLKEIIMDILDAARYVQSCFEWESPVRSSIAFVFWIVACVYGDLETVPLVL 744
            ..|..:::..|:|:|:|.:.:.|.:..::.:|||:|||.:||:||||.::|.....:|..:||.|
Mouse   649 SRKLSKKILSRDVDRVKRLTLAIWNTVQFFKSCFQWESTLRSTIAFVVFLVTVWNFELYMIPLAL 713

  Fly   745 LLIILKNWLVRLITG----TTDAAAHYDYEYDEDDDDDKEKEEKKSIKERLQAIQEVSQTVQNTI 805
            ||:.|.|:| |.:.|    |.|:....|.|  |:..:::::.|||.|.||:..:|::..||||.:
Mouse   714 LLLFLYNFL-RPMKGKASSTQDSQESTDVE--EEGKEEEKESEKKGIIERIYMVQDIVSTVQNIL 775

  Fly   806 GYLASLGESTINTFNFSVPELTWLAVVLLLGAILVLHFVPLRWLLLFWGLMKFSRRLLRPNTIPN 870
            ..:||.||...|.||::||.|:.||.::|....::|:|:|||:::|.||:.||:::|..|.:|.|
Mouse   776 EEVASFGERIKNVFNWTVPFLSLLACLILAITTVILYFIPLRYIILLWGINKFTKKLRNPYSIDN 840

  Fly   871 NELLDFLSRVPDNEEINQYRELPPSAPTDQTRNNPKKKLKGSXS 914
            |||||||||||.:.:..||.||               ||.||.|
Mouse   841 NELLDFLSRVPSDIQKVQYAEL---------------KLCGSHS 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mctp	NP_001261078.1	C2A_MCTP_PRT	237..357	CDD:176007	51/119 (43%)
		C2B_MCTP_PRT	390..497	CDD:176022	30/115 (26%)
		C2C_MCTP_PRT	537..658	CDD:176023	71/120 (59%)
		PRT_C	<789..893	CDD:285560	48/103 (47%)
Mctp2	NP_001019874.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..40		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..178		7/36 (19%)
		C2A_MCTP_PRT	195..314	CDD:176007	51/120 (43%)
		C2B_MCTP_PRT	357..469	CDD:176022	30/115 (26%)
		C2C_MCTP_PRT	509..627	CDD:176023	71/120 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	728..752		5/25 (20%)
		PRT_C	<771..>824	CDD:337028	22/52 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833263
Domainoid	1	1.000	124	1.000	Domainoid score	I5514
eggNOG	1	0.900	-	-		E1_KOG1030
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	548	1.000	Inparanoid score	I1141
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59961
OrthoDB	1	1.010	-	-		D139564at33208
OrthoFinder	1	1.000	-	-		FOG0002654
OrthoInspector	1	1.000	-	-		otm42334
orthoMCL	1	0.900	-	-		OOG6_101057
Panther	1	1.100	-	-	O	PTHR45911
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770