DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mctp and mctp-1

DIOPT Version :9

Sequence 1:	NP_001261078.1	Gene:	Mctp / 37165	FlyBaseID:	FBgn0034389	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001382288.1	Gene:	mctp-1 / 172382	WormBaseID:	WBGene00017063	Length:	810	Species:	Caenorhabditis elegans

Alignment Length:	825	Identity:	290/825 - (35%)
Similarity:	455/825 - (55%)	Gaps:	86/825 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 LRHRWSRAKSKDRL-----------------GRKSPSDFLEESTDYAADYSSEGSSVTHSPRHRS 159
            |..|..:.|.|::|                 |.|:..|...|..|...:               |
Worm     6 LIRRRKKKKKKEQLVQIVEKGENEDERIMMKGGKNEEDHENEEDDDNVE---------------S 55

  Fly   160 TTIGGSPLAREFRATAKMAQVIQRFGGSMEGRIDEHPENGSAGCSP------------------P 206
            :.||.|||.|..|.:|.:       |.|...:..::..:.|...||                  |
Worm    56 SLIGCSPLTRRRRKSAAV-------GTSTSEKNHQNHNHPSPRKSPGFRFRRIFDTFTFTKSLKP 113

  Fly   207 ELSTQQQLEALQANELRRKREAQLRQFVFFQLRVHLKSGSDLVAMDKNGLSDPYVKFKVGGRLLH 271
            :.|.:...:..:::|.::..|......|...:.|.||:|.||...|.:|.|||||||:....:::
Worm   114 QYSLENNNDEEESDETQKCAETAELDVVTLLMEVRLKNGEDLPVKDASGSSDPYVKFRYKDNIVY 178

  Fly   272 KSRTIHRDLNPVWDEVFIVPIEDPFQPIIVKVFDYDWGLQDDFMGSAKLDLTQLELGKAEDIHLQ 336
            ||.||.::|||.|||.|.:.::|...||.::|||:|....|||||:|::|::|::.....:.|::
Worm   179 KSGTIFKNLNPSWDEEFQMIVDDVTCPIRLEVFDFDRFCTDDFMGAAEVDMSQVKWCTPTEFHVE 243

  Fly   337 LCDSSGNGGSGLGEILINLTLWPRSQEDKEMHFQRNSK--LAESSKRLK-----SQIWSSVVTIL 394
            |.|..   ....|.:.:.:|:.|.:|.:.:...|:.:|  |:.|.|:.:     :|.|..:|.|:
Worm   244 LTDEV---NQPTGRVSVCVTITPMTQLEVQQFHQKATKGILSTSEKKKEQRPNNTQEWDKIVNIV 305

  Fly   395 LVKAKDLPLAEDGSKLNDTHFKFRLGNEKYKSK--SSWTERWLEQFDLHLFDE-DQNLEIALWNR 456
            ||:.|.:.:.|   ::.|...||:||.||||:|  :....:|:||||||:||. ||.|::|..:|
Worm   306 LVEGKGIRIDE---RIPDAFCKFKLGQEKYKTKVCTGIEPKWVEQFDLHVFDSADQMLQMACIDR 367

  Fly   457 NT--LYGKAIIDLSVFQRENTHGIWKPLEDCP--GEVHLMLTISGT-TALETISDLKAFKEDPRE 516
            ||  :.|:..||||.|..:.|...|..||:.|  .:|.|::|:||: .|.|||...:....|.|.
Worm   368 NTNAIIGRLSIDLSSFSHDETVQHWYHLENAPDDAQVLLLITVSGSHGAGETIETDEFNYNDIRN 432

  Fly   517 AQLLRERYKFLRCLQNLRDVGHLTVKVFGATGLAAADIGGKSDPFCVLELGNARLQTQTEYKTLT 581
            .::  ::|.......:|.|||.||||:|||..|.|.|.|||||||.||||.|.|:||.|.||||:
Worm   433 TRI--QKYDVTNSFSDLADVGTLTVKLFGAEDLVAKDFGGKSDPFAVLELVNTRVQTNTIYKTLS 495

  Fly   582 PNWNKIFTFNVKDITQVLEITVFDEDRDHRVEFLGKLVIPLLRIKSGVKRWYTLKDKNLCVRAKG 646
            |:||||:||.||||...|::|::|||.::|.||||::.|||..|::..||||.|||:.|..|.||
Worm   496 PSWNKIYTFAVKDIHTCLQVTIYDEDPNNRFEFLGRVQIPLKSIRNCQKRWYGLKDEKLRKRVKG 560

  Fly   647 NSPQIQLELTVVWSEIRAVCRALQPKEEKLIQQEAKFKRQLFLRNVNRLKEIIMDILDAARYVQS 711
               ::.||:.|:|:.|||..|..:|||.|.:.||.|||..||......|||::..:......::.
Worm   561 ---EVLLEMDVIWNPIRAAIRTFKPKEIKYMSQEQKFKASLFKTYFGELKEVVNVLASYKNQMEY 622

  Fly   712 CFEWESPVRSSIAFVFWIVACVYGDLETVPLVLLLIILKNWLVRLITG-TTDAAAHYDYEYDEDD 775
            ...|.|..:|..|:|.:::...|..:..:||::|.:...|:::...:| .:|:.:.:..:..:.:
Worm   623 LLSWHSKPKSLTAYVIFMLFVYYFQIYFIPLMILALFGYNFILSKTSGDISDSPSRHSLKGQKSE 687

  Fly   776 DDDKEKEEKKSIKERLQAIQEVSQTVQNTIGYLASLGESTINTFNFSVPELTWLAVVLLLGAILV 840
            ::|  ::....|::.:.::||:..:||:.:.:...|.:...|||||:...|:.|||::|..|.::
Worm   688 EED--EKTGTGIRDAISSVQEILLSVQSYLHFATQLLQKIKNTFNFTDIWLSTLAVIVLSLAFVL 750

  Fly   841 LHFVPLRWLLLFWGLMKFSRRLLRPNTIPNNELLDFLSRVPDNEE 885
            |:||||||::|.||..|||::|..||.:.||||||||||||...|
Worm   751 LYFVPLRWIILVWGTNKFSKKLRNPNFVDNNELLDFLSRVPSRTE 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mctp	NP_001261078.1	C2A_MCTP_PRT	237..357	CDD:176007	45/119 (38%)
		C2B_MCTP_PRT	390..497	CDD:176022	46/113 (41%)
		C2C_MCTP_PRT	537..658	CDD:176023	69/120 (58%)
		PRT_C	<789..893	CDD:285560	45/97 (46%)
mctp-1	NP_001382288.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166386
Domainoid	1	1.000	118	1.000	Domainoid score	I3688
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75211
Inparanoid	1	1.050	455	1.000	Inparanoid score	I891
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59961
OrthoDB	1	1.010	-	-		D139564at33208
OrthoFinder	1	1.000	-	-		FOG0002654
OrthoInspector	1	1.000	-	-		oto20036
orthoMCL	1	0.900	-	-		OOG6_101057
Panther	1	1.100	-	-	LDO	PTHR45911
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2311
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940