DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mctp and mctp1b

DIOPT Version :9

Sequence 1:	NP_001261078.1	Gene:	Mctp / 37165	FlyBaseID:	FBgn0034389	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_002663716.2	Gene:	mctp1b / 100334264	ZFINID:	ZDB-GENE-090313-382	Length:	859	Species:	Danio rerio

Alignment Length:	936	Identity:	342/936 - (36%)
Similarity:	500/936 - (53%)	Gaps:	124/936 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VDQVELDQQQQPGSSSTVSGSTPPLQISPHGSPSLQQSQRLGKHLSKSASEL--------NGHDC 66
            ||.|....|||         :...|..|.||...|..|.:|.|...|..|..        :|.|
Zfish     7 VDDVSPSHQQQ---------NQRGLWKSFHGKSKLPGSPKLSKKARKPESVFRIFKKKRDHGLD- 61

  Fly    67 HLSESPHISPKRAKSAVAQQLAGVSSGGVASGVGVLQKTHGFFNNLRHRWSRAKSKDRLGRKSPS 131
                       ||.|:....|...::.|..||                       :.|.|....|
Zfish    62 -----------RAVSSSQPNLHSAAADGEGSG-----------------------RTRCGTPEMS 92

  Fly   132 DFLEESTDYAADYSSEGSSVTHSPRHRSTTIGGSP-------LAREFRATAKMAQVIQRFGGSME 189
                 :...||..:|.|:.:....|      .|||       |..:::..:......|......:
Zfish    93 -----ACTAAAAAASLGAEIQMLKR------SGSPKPTLSQLLESQYKPASTCTDDAQTHSDEEQ 146

  Fly   190 GRIDEHPENGSAGCSPPELSTQQQLEALQANELRRKREAQLRQFVFFQLRVHLKSGSDLVAMDKN 254
            |.........:.|...|.|.|.                      ..:||.:.||.|::|...|:.
Zfish   147 GDKSVGVTTVAKGAVQPALPTS----------------------TLYQLDIVLKRGNNLAIRDRA 189

  Fly   255 GLSDPYVKFKVGGRLLHKSRTIHRDLNPVWDEVFIVPIEDPFQPIIVKVFDYDWGLQDDFMGSAK 319
            |.||||||||:.|:.:.:|:.|.::|||||||...:.:::..:|:.:||||||:||||||||||.
Zfish   190 GTSDPYVKFKLAGKEVFRSKIIQKNLNPVWDERVCLIVDNLKEPLYMKVFDYDFGLQDDFMGSAY 254

  Fly   320 LDLTQLELGKAEDIHLQLCDSSGNGGSGLGEILINLTLWPRSQEDKE-MHFQRNSKLAESSKRL- 382
            |.|..||..:..|:.|.|.|.. .....||.:.:.:||:|||..|:| :..|:..::.:.|.||
Zfish   255 LYLESLEQQRPLDVRLDLQDPH-CPDQDLGSLELTVTLYPRSPADREALRQQQQQQMQQQSPRLS 318

  Fly   383 ----KSQIWSSVVTILLVKAKDLPLAEDGSKLNDTHFKFRLGNEKYKSKS---SWTERWLEQFDL 440
                |.|:|..:|:|.|::.::| :|.|.:..:|.:.||:||.:|||||:   :...:|.|||||
Zfish   319 DLHRKPQMWKGIVSIRLIEGRNL-IAMDQNGFSDPYVKFKLGPQKYKSKTIPKTLNPQWREQFDL 382

  Fly   441 HLFDEDQN-LEIALWN-----RNTLYGKAIIDLSVFQRENTHGIWKPLEDCPGEVHLMLTISGTT 499
            ||:||:.. |||::|:     |:...|:..::|....||.||.:...||:..|.:.:::|:: .|
Zfish   383 HLYDEEGGILEISVWDKDIGRRDDFIGQCELELWKLSREKTHKLELHLEEDKGTLVVLVTLT-AT 446

  Fly   500 ALETISDLKA-FKEDPREAQLLRERYKFLRCLQNLRDVGHLTVKVFGATGLAAADIGGKSDPFCV 563
            |..:||||.. ..:||.:.|.:..||..|:...||:|||.|.||:..|.||.|||:.|||||||:
Zfish   447 ATVSISDLSVNLLDDPDQRQHISRRYSPLKSFFNLKDVGILQVKILRAEGLMAADVTGKSDPFCI 511

  Fly   564 LELGNARLQTQTEYKTLTPNWNKIFTFNVKDITQVLEITVFDEDRDHRVEFLGKLVIPLLRIKSG 628
            .||.|.||||.|.||||.|.|||:|:||||||..||||:|:|||||...:||||:.||||.|.|.
Zfish   512 AELCNDRLQTHTVYKTLNPEWNKVFSFNVKDIHSVLEISVYDEDRDRSADFLGKVAIPLLNICSS 576

  Fly   629 VKRWYTLKDKNLCVRAKGNSPQIQLELTVVWSEIRAVCRALQPKEEKLIQQEAKFKRQLFLRNVN 693
            .::.|.||:|.|....||   .|.|:..|:::.:||..|...|.|:|.|::|||..:||..:|.|
Zfish   577 QQKAYVLKNKELTGPTKG---VILLQADVIFNAVRASLRTFVPAEQKYIEEEAKVSKQLLQQNFN 638

  Fly   694 RLKEIIMDILDAARYVQSCFEWESPVRSSIAFVFWIVACVYGDLETVPLVLLLIILKNWLVRLIT 758
            |:|..::.:::...|:.|||:||||.||..||:.::|.....::..:||.|||:::.|:| |..:
Zfish   639 RVKRCVLFLINVGYYINSCFQWESPRRSLCAFLIFVVVVWNFEIYMLPLSLLLLLIWNYL-RKAS 702

  Fly   759 GTTDAAAHYDYEYD--EDDDDDKEKE----EKKSIKERLQAIQEVSQTVQNTIGYLASLGESTIN 817
            |......:.:...|  ||.|:|.:||    |||...::..|||:|..|||..:..:||.||...|
Zfish   703 GKGTCEGNVEVMEDLLEDVDEDSDKEDKDSEKKGFLDKFYAIQDVIITVQTALDEVASFGERVKN 767

  Fly   818 TFNFSVPELTWLAVVLLLGAILVLHFVPLRWLLLFWGLMKFSRRLLRPNTIPNNELLDFLSRVPD 882
            |||:|||.|:|||:.:|.....:.:|:|||:::|.||:.||:::|..|.:|.||||||||||||.
Zfish   768 TFNWSVPFLSWLAITVLCAGATITYFIPLRYIVLVWGINKFTKKLRAPYSINNNELLDFLSRVPS 832

  Fly   883 NEEINQYRELPPSA---PTDQTRNNP 905
            :.::.||:||...|   |..:.||||
Zfish   833 DIQMVQYKELKADANQSPNKKRRNNP 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mctp	NP_001261078.1	C2A_MCTP_PRT	237..357	CDD:176007	53/119 (45%)
		C2B_MCTP_PRT	390..497	CDD:176022	41/115 (36%)
		C2C_MCTP_PRT	537..658	CDD:176023	69/120 (58%)
		PRT_C	<789..893	CDD:285560	50/103 (49%)
mctp1b	XP_002663716.2	C2A_MCTP_PRT	172..293	CDD:176007	55/121 (45%)
		C2B_MCTP_PRT	330..445	CDD:176022	41/116 (35%)
		C2C_MCTP_PRT	485..603	CDD:176023	69/120 (58%)
		PRT_C	<751..>804	CDD:285560	23/52 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575964
Domainoid	1	1.000	128	1.000	Domainoid score	I5264
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75211
Inparanoid	1	1.050	531	1.000	Inparanoid score	I1179
OMA	1	1.010	-	-		QHG59961
OrthoDB	1	1.010	-	-		D139564at33208
OrthoFinder	1	1.000	-	-		FOG0002654
OrthoInspector	1	1.000	-	-		otm24820
orthoMCL	1	0.900	-	-		OOG6_101057
Panther	1	1.100	-	-	O	PTHR45911
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910