DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mctp and esyt2b

DIOPT Version :9

Sequence 1:	NP_001261078.1	Gene:	Mctp / 37165	FlyBaseID:	FBgn0034389	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_021333611.1	Gene:	esyt2b / 100330508	ZFINID:	ZDB-GENE-090615-2	Length:	892	Species:	Danio rerio

Alignment Length:	791	Identity:	155/791 - (19%)
Similarity:	260/791 - (32%)	Gaps:	272/791 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 ILINLTL---WPRSQEDKEMHFQRNSKLAESSKRLKSQIWSSVVTILLVKAKDLPL------AED 406
            :||.||:   |.|:...|.....|...:.:....:|.::          .|.:||.      .|.
Zfish    88 LLIALTIFFFWKRNTNSKNTRLSRAMSIFDPDDAVKQEL----------DATELPSWVHYPDVER 142

  Fly   407 GSKLNDT---------HFKFRLGNEKYKSKSSWTERWLEQFDLHLFD-EDQNLEI---ALWNRNT 458
            ...||.|         .|..:|..|..:.....:...|..|.....| .|:.|.|   .:::.|.
Zfish   143 VEWLNKTVNQMWPYVCQFVDKLFKETIEPAIKESNAHLSTFSFTKIDLGDKPLRINGVKVYSENV 207

  Fly   459 LYGKAIIDLSVFQRENT--------------------HGIWKP-LEDCPGEVHLM---------- 492
            ...:.|:||.:....||                    ||:.:. ||...|.:.|:
Zfish   208 DKRQIIMDLQISYVGNTEIDVDVKRYYCRAGIKSIQLHGVLRVILEPLLGNMPLVGAFSLFFLKK 272

  Fly   493 ----LTISGTTALETISDLKAFKEDPREAQLLRERYKFLRCLQNLRDVGHLTVKVFG-------- 545
                :..:|.|.:..|..|..|.:     |::::.......|.|     .:||.:.|
Zfish   273 PLLDINWTGLTNILDIPGLNGFSD-----QMIQDIISAYMVLPN-----RITVPLIGEVELAQLR 327

  Fly   546 --------------ATGLAAAD------IGGKSDPFCVLELGNARLQTQTEYKTLTPNWNKIFTF 590
                          |..|...|      |.|||||:.:|.:.|...:::|..:.|.|.||:::..
Zfish   328 FPMPKGVLRIYFIEAQNLEVKDTYLGGLIKGKSDPYGMLLVSNQLFRSKTIKECLHPKWNEVYEA 392

  Fly   591 NVKDIT-QVLEITVFDEDRDHRVEFLGKLVIPL--LRIKSGVKRWYTLKDKNLCVRAKGNSPQIQ 652
            .|.:.: |.|||.:||||.| :.:|||.|:|.|  |..:..|..|:.|:
Zfish   393 LVYEPSGQHLEIELFDEDPD-KDDFLGSLMIDLTELHKEQKVDEWFDLE---------------- 440

  Fly   653 LELTVVWSEIRAVCRALQPKEEKLIQQEAKFKRQLFLRNVNRLKEIIMDILDAARYVQSCFE--- 714
             |:|.....:|....:|....|||.|.:...:     .|.|....:::..||:|..:.|.||
Zfish   441 -EVTTGKLHLRLEWLSLYSSAEKLDQVQKSIR-----TNDNLSSALLIVNLDSASNLPSVFEGSF 499

  Fly   715 --WESPVRSSIAFVFWIVACVYGD-------------LETVPLVLLLIILKNWLVRLITGTTDAA 764
              .....|.:...||    |...|             ::..|.|.|.:..|....::...|::..
Zfish   500 GCGNLKERRASGLVF----CENADSLCRELFSGKKVSIDPNPFVKLTVGQKTCTSKVRYKTSEPL 560

  Fly   765 AHYDY----------EYDEDDDDDKEKEEKKSIKERLQA-IQEVSQTVQNTIGYLASLGESTINT 818
            ....:          |.:.:..|.|.|....|::..|.: :.||..|:.......:|...||:.
Zfish   561 WEETFPFLINNPQTQELEIEVKDSKHKCSLGSLQVSLASLLNEVDMTLNQQFPLQSSGPNSTLK- 624

  Fly   819 FNFSVPELTWLAVVLLLGAILVLHFVPLRWLLLFWGLMKFSRRLL---------RPNTIPNNELL 874
                                                 :|.:.|:|         .|:::
Zfish   625 -------------------------------------LKMALRILSLEKEVTSSHPSSV------ 646

  Fly   875 DFLSRVPDNEEINQYRELPP-----SAPTD-QTRNNP--------KKKLKGSXSITSADAAMASL 925
                ||....:.|..  :||     |:||| |...||        .:..:||..
Zfish   647 ----RVRITSQSNTC--VPPKPQATSSPTDIQPSQNPPCTPPPDTPQGKRGSDG----------- 694

  Fly   926 SPLQSSALGGAAGGSGSGSGYGGRQ----------------------QQLMQRFRANTSQLKHKF 968
            ||::.:..|.:....|.||.: .||                      ||.:|:.:..:....:..
Zfish   695 SPVRLADAGRSLSSLGIGSSH-KRQSHRDSTPSLASDISLPCATLELQQRLQQLQNGSGLNLYPL 758

  Fly   969 GQAKSLSLSHS 979
            |:.: |::.||
Zfish   759 GEVQ-LTVRHS 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mctp	NP_001261078.1	C2A_MCTP_PRT	237..357	CDD:176007	3/5 (60%)
		C2B_MCTP_PRT	390..497	CDD:176022	28/160 (18%)
		C2C_MCTP_PRT	537..658	CDD:176023	41/151 (27%)
		PRT_C	<789..893	CDD:285560	14/113 (12%)
esyt2b	XP_021333611.1	SMP_LBD	139..318	CDD:332594	35/188 (19%)
		C2A_C2C_Synaptotagmin_like	333..453	CDD:176037	39/137 (28%)
		C2B_Synaptotagmin-like	480..619	CDD:176015	26/142 (18%)
		C2C_KIAA1228	757..882	CDD:175996	4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2311
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940