DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12b2 and cyp11c1

DIOPT Version :9

Sequence 1:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_017206857.1	Gene:	cyp11c1 / 791124	ZFINID:	ZDB-GENE-070828-1	Length:	701	Species:	Danio rerio

Alignment Length:	501	Identity:	135/501 - (26%)
Similarity:	225/501 - (44%)	Gaps:	63/501 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ARSFGEIP---GPSLLRMLSFFMPGGALRNTNLIQMNRLMREMY---GDIYCIPGMMGKPNAVFT 108
            ||.|.|||   ....:.:|.|:      |:....:|::.|.|.:   |.||  ...:|..::|..
Zfish   219 ARLFQEIPDTGSNGWMNLLRFW------RDGRFSRMHKHMEESFRRLGPIY--REHLGSQSSVNI 275

  Fly   109 YNPDDFEMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKV 173
            ..|.|....:|:||:.|.|:.|:....:|:..|..  |||   ....|.||...|..:|..:|..
Zfish   276 MLPMDTGELFRSEGLHPRRMTLQPWATHRETRRHS--KGV---FLKNGTEWRADRLLLNREVMVS 335

  Fly   174 QNVRQNLPQLDQISKEFIDKLETQRNPE------THTLTTDFHNQLKMWAFESISFVALNTRMGL 232
            .:|.:.||.||:::::|...|..:...:      .||||.|....|..:|.|:...|....|:||
Zfish   336 SSVHRFLPLLDEVAQDFCRSLRRRVQADGFEKAGQHTLTLDPSPDLFRFALEASCHVLYGERIGL 400

  Fly   233 LSDNPDPNADRLAKHMRD---------FFNYSFQFDVQPSIWTFYKTAGFKKFLKTYDNITDITS 288
            .|..|...::|....:..         :........::.|:||.:.||        :|:|.....
Zfish   401 FSSCPSDESERFISAVERMLATTPPLLYLPPRLLLRLRASLWTTHATA--------WDDIFSHAE 457

  Fly   289 NYIETAMRGFGKNDDGKTKC----VLEQLLEHNK---KVAVTMVMDMLMAGIDTTSSACLTILYH 346
            ..|:.:.:...........|    ||.:|:|..:   ::....:.:::..|:|||:......|:.
Zfish   458 QRIQRSYQRLQARPSAAPDCSFPGVLGKLMEAGQLSLELIRANITELMAGGVDTTAVPLQFALFE 522

  Fly   347 LARNPSKQEKLRRELLRILPTTKDSLTD--QNTKNMPYLRACIKEGLRITSITPGNFRITPKDLV 409
            |||||..||.:|.:   :|.:.:.:..|  :..:..|.|:..|||.||:..:.....|...:|:|
Zfish   523 LARNPDVQECVRAQ---VLSSWQQASGDPLKALQGAPLLKGTIKETLRLYPVGITVQRYPVRDIV 584

  Fly   410 LSGYQVPRGTGVLMGVLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAARTRNPFVYLPFGF 474
            |..|.||.||.|.:.:..|....:.|::...|.|.||     :.|..|..|...|:    |.|||
Zfish   585 LQNYHVPAGTLVQVCLYPLGRSAEVFSRPECFDPSRW-----SADADAGSAGGFRS----LAFGF 640

  Fly   475 GPRTCIGKRIAELEIETLLVRLLRSYKVSWLPETPIEYESTIILSP 520
            |.|.|:|:||||.|::.||:.:||::|::......:..:.|:||.|
Zfish   641 GSRQCVGRRIAENEMQLLLMHILRTFKLTVSSTEELSTKYTLILQP 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	125/478 (26%)
cyp11c1	XP_017206857.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820