Protein Alignment Cyp12b2 and cyp46a1.3

DIOPT Version :10

• Sequence 1: NP_611370.2
• Gene: Cyp12b2 / 37163
• FlyBaseID: FBgn0034387
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_001027517.1
• Gene: cyp46a1.3 / 613109
• XenbaseID: XB-GENE-969052
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 512
• Identity: 113/512 - (22%)
• Similarity: 208/512 - (40%)
• Gaps: 87/512 - (16%)

  Fly    53 FGEIPGPSLLRMLSFFMPGGALRNTNLIQMNRLMR-------EMYGDIYCIPG------MMGKPN 104
            :..||||.   ..|||: |.:.....|::.|.||.       :.||.:..|.|      ::..|.
 Frog    36 YDHIPGPP---RDSFFL-GHSPTMLRLMKNNLLMYDHFLGWVQKYGPVVRINGLHRVIILVVSPE 96

  Fly   105 AVF------TYNPDDFEMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWADIR 163
            ||.      .|:.|.|.....|  ::.:|                 |.|.|.:.......|...|
 Frog    97 AVKELLMSPKYSKDKFYDVIAN--MFGVR-----------------FMGKGLVTDRDYDHWHKQR 142

  Fly   164 NKVNPVLMKVQNVRQNLPQLDQISKEFIDKLETQRNPETHTLTTDFHNQLKMWAFESISFVALNT 228
            ..::|...:...:....| .::.::|.::||..:.:.:..   ...|:.|.....:.|..||...
 Frog   143 RIMDPAFSRTYLMGLMGP-FNEKAEELMEKLMEKADGKCE---IKMHDMLSRLTLDVIGKVAFGM 203

  Fly   229 RMGLLSDN--PDPNADRLAK----HMRD-FFNYS-----FQFDVQPSIWTFYKTAG--FKKFLKT 279
            .:..|:|:  |.|.|..|..    .||: ...||     |...||.||....:|..  .::..|.
 Frog   204 ELNSLNDDLTPFPKAISLVMKGIVEMRNPMVRYSLAKRGFIRKVQESIRLLRQTGKECIERRQKQ 268

  Fly   280 YDNITDITSNYIETAMRGFGKNDDGKTKCVLEQLLEHNKKVAVTMVMDMLMAGIDTTSSACLTIL 344
            ..:..:|..:.:...::|....::    |..|.||::        .:...:||.:||::....::
 Frog   269 IQDGEEIPVDILTQILKGAAMEEE----CDPEILLDN--------FVTFFIAGQETTANQLSFVV 321

  Fly   345 YHLARNPSKQEKLRRELLRILPTTKDSLTDQNTKNMPYLRACIKEGLRITSITPGNFRITPKDLV 409
            ..|.|||...||.:.|:..::.:.:| :..::...:.||...:||.||:....||..|...:|:|
 Frog   322 MELGRNPEILEKAQAEIDEVIGSKRD-IEYEDLGKLQYLSQVLKETLRLYPTAPGTSRGLTEDMV 385

  Fly   410 LSGYQVPRGTGVLMGVLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAARTRNPFV-YLPFG 473
            :.|.:||....:::....:...::|::....|.|:|:     :||        ...|:. |.||.
 Frog   386 IDGVKVPENVTIMLNSYIMGRMEQYYSDPLTFNPDRF-----SPD--------APKPYYSYFPFS 437

  Fly   474 FGPRTCIGKRIAELEIETLLVRLLRSYKVSWLPETPIEYESTIILSPCGDIRFKLEP 530
            .|||:|||:..:::|.:.::.:||:.|:.........:...|..|.|...:..:|.|
 Frog   438 LGPRSCIGQVFSQMEAKVVMAKLLQRYEFELAEGQSFKILDTGTLRPLDGVICRLRP 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	CYP24A1-like	87..525	CDD:410677	99/471 (21%)
cyp46a1.3	NP_001027517.1	CYP46A1-like	66..490	CDD:410706	99/472 (21%)