DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12b2 and si:dkey-91i10.3

DIOPT Version :9

Sequence 1:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001116749.1	Gene:	si:dkey-91i10.3 / 565876	ZFINID:	ZDB-GENE-081105-124	Length:	513	Species:	Danio rerio

Alignment Length:	469	Identity:	133/469 - (28%)
Similarity:	232/469 - (49%)	Gaps:	46/469 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RSFGEIPGPSLLRMLSFFMPGGALRNTNLIQMNRLMREMYGDIYCIPGMMGKPNAVFTYNPDDFE 115
            ::..::.|||.|..|.:....|..:.|:.:|:..  .::||.::  ....|....|...:.|..|
Zfish    44 KTMDDLDGPSFLTSLYWLFGKGYFQTTHQMQIEH--SKIYGPLW--KSKYGPLVIVNVASADLIE 104

  Fly   116 MTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKVQNVRQNL 180
            ...|.||..|||..:.....|||: |...:    |..::.|.||..||:.:||.::|.::|....
Zfish   105 QVLRQEGRHPIRTDMPHWRGYRKL-RNHAY----GPLTEMGPEWQRIRSILNPRMLKPKHVSNYT 164

  Fly   181 PQLDQISKEFID---KLETQRNPETHTLTTDFHNQLKMWAFESISFVALNTRMGLLSDNPDPNAD 242
            ..::.:..:||:   ||:|.:..:  .:..|...:|..:|||.||.|...||||.|:|.......
Zfish   165 NAINGVVSDFIEKMAKLKTTKGND--VMVYDVAGELYKFAFEGISSVLFETRMGCLNDEIPEETQ 227

  Fly   243 RLAKHMRDFFNYSFQFDVQPSIWTFYK-----TAGFKKFLKTYDNITDITSNYIETAMRGFGKND 302
            :.      .|:....|.:.|.:..|.|     ...:|.|:..:|::..:....::..|...  .:
Zfish   228 KF------IFSVGEMFRLSPIVILFPKFLWPYMPFWKHFVAVWDHLFKVADELVQQKMTEI--QE 284

  Fly   303 DGKTKCVLE-QLLEH---NKKVAVTMVM----DMLMAGIDTTSSACLTILYHLARNPSKQEKLRR 359
            ..||...:| :.|.|   :::::.|.|:    ::|:||:||||:.....||||||.|..|:||..
Zfish   285 KVKTGSPVEGEYLTHLLISEQMSFTEVLGSITELLLAGVDTTSNTISWALYHLAREPEIQQKLHE 349

  Fly   360 ELLRILPTTKDSLTDQNTKNMPYLRACIKEGLRITSITPGNFRITPK-DLVLSGYQVPRGTGVLM 423
            |::.:.|..|...:|..|: ||.|:|.::|.||:..:.|||.|:..: ::|:..:..|:.|...:
Zfish   350 EVVSVCPGDKTPSSDDITR-MPLLKAIVRETLRLYPVVPGNARVVAENEIVVGDHLFPKNTLFHL 413

  Fly   424 GVLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAARTRNPFVYLPFGFGPRTCIGKRIAELE 488
            ....:|.|:..|.....|:|:||::..         ...:::||..:|||||.|.|:|:|:||||
Zfish   414 CHFAVSYDETVFPDPFAFLPQRWIREQ---------KQLSQHPFGSVPFGFGIRACLGRRVAELE 469

  Fly   489 IETLLVRLLRSYKV 502
            :..||.||::.|:|
Zfish   470 MYLLLSRLIKRYEV 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	132/461 (29%)
si:dkey-91i10.3	NP_001116749.1	p450	52..510	CDD:278495	132/461 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.880