DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12b2 and cyp11a2

DIOPT Version :9

Sequence 1:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_021329545.1	Gene:	cyp11a2 / 563363	ZFINID:	ZDB-GENE-130911-1	Length:	512	Species:	Danio rerio

Alignment Length:	518	Identity:	143/518 - (27%)
Similarity:	246/518 - (47%)	Gaps:	69/518 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LADSRIDEKWQQARSFGEIPGP---SLLRMLSFFMPGGALRNTNLIQMNRLMREMYGDIYCIPGM 99
            |.||.:       |.|.||||.   ||..:.:|...|| |||.:.|.::..  ..:|.||  ...
Zfish    36 LQDSTV-------RPFNEIPGQWRNSLKSVFAFAKMGG-LRNIHRIMVHNF--NTFGPIY--REK 88

  Fly   100 MGKPNAVFTYNPDDFEMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWADIRN 164
            :|...:|....|:|..:.::.||.:|.|:.:::...||....    :..|.|..| |::|...|.
Zfish    89 VGFYESVNIIKPEDAAILFKAEGHYPKRLTIDAWTAYRDYRN----RKYGVLLKD-GEDWKSNRI 148

  Fly   165 KVNPVLM--KVQNVRQNLPQLDQISKEFIDKL--ETQRNPETHTLTTDFHNQLKMWAFESISFVA 225
            .:|..::  |||.  ..:|.||::.::|:.::  :.:|:.: :..|||..::|..:|.||:|.|.
Zfish   149 ILNKEVISPKVQG--NFVPLLDEVGQDFVARVNKKIERSGQ-NQWTTDLSHELFKFALESVSAVL 210

  Fly   226 LNTRMGLLSDNPDPNADRLAKHMRDFFNYSFQF---------DVQPSIWTFYKTAGFKKFLKTYD 281
            ...|:|||.|..||::.|....:...|..:...         .::..||        :..::.:|
Zfish   211 YGERLGLLLDYIDPDSQRFIDCITLMFKTTSPMLYLPPGLLRPIRSKIW--------RNHVEAWD 267

  Fly   282 NITDITSNYIETAMRGFGKNDDGKTKC--VLEQLLEHNK------KVAVTMVMDMLMAGIDTTSS 338
            .|.:.....|:...|...||.:|..|.  ||..||..:|      |.:||   :::..|:|||:.
Zfish   268 GIFNQADRCIQNIYRQLRKNPEGNGKYTGVLASLLMLDKLSIEDIKASVT---ELMAGGVDTTAI 329

  Fly   339 ACLTILYHLARNPSKQEKLRRELLRILPTTKDSLTDQNTKNMPYLRACIKEGLRITSITPGNFRI 403
            ..|..||.|||||..||::|.|:......:|..:. |..|.:|.::..:||.||:..:.....|.
Zfish   330 TLLWTLYELARNPDLQEEIRAEISAARIASKGDMV-QMLKMIPLVKGTLKETLRLHPVAVSLQRY 393

  Fly   404 TPKDLVLSGYQVPRGTGVLMGVLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAARTRNPFV 468
            ..:|:|:..|.:|.||.|.:|:..:..|.:.|....:::|.||:.|.             .:.|.
Zfish   394 ITEDIVIQKYHIPAGTLVQLGLYAMGRDHQVFPNPEQYLPSRWVNSQ-------------NHYFK 445

  Fly   469 YLPFGFGPRTCIGKRIAELEIETLLVRLLRSYKVSWLPETPIEYESTIILSPCGDIRFKLEPV 531
            .|.||||||.|:|:||||.|::..|:.:|.::::....:..::....:||.|...|...::|:
Zfish   446 SLSFGFGPRQCLGRRIAETEMQLFLIHMLENFRIEKQRQMEVKSMFELILLPEKPIMLTIKPL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	129/475 (27%)
cyp11a2	XP_021329545.1	p450	69..505	CDD:306555	126/472 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820