DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12b2 and cyp27a7

DIOPT Version :9

Sequence 1:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_002663445.1	Gene:	cyp27a7 / 402831	ZFINID:	ZDB-GENE-081104-519	Length:	524	Species:	Danio rerio

Alignment Length:	476	Identity:	131/476 - (27%)
Similarity:	226/476 - (47%)	Gaps:	37/476 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 ADSRIDEKWQQARSFGEIPGPSLLRMLSFFMPGGALRNTNLIQMNRLMREMYGDIYCIPGMMGKP 103
            |...:.:..::.::..::|...:..||...:..|.|...:.:|:..  :::||.:|.|  .:|..
Zfish    39 ASVSVQDGHRKLKTEADLPEIKIFTMLYRLLFKGYLSRMHELQLYE--KQLYGPLYKI--NVGNF 99

  Fly   104 NAVFTYNPDDFEMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVG-GLASDQGQEWADIRNKVN 167
            .:|...:.|..|...|.:..:|.|..:.....||.:      ||:| |..:::|::|..:|..:|
Zfish   100 QSVALNSVDLLEELLRKDEKFPSRGDMTLWTEYRDM------KGIGYGPFTEEGEKWYKLRAVLN 158

  Fly   168 PVLMKVQNVRQNLPQLDQISKEFIDKLETQRN-PETHTLTTDFHNQLKMWAFESISFVALNTRMG 231
            ..::..::..|....::.:..:||.::...|. ..|..|.::..|:|..::.|.||.:...||:|
Zfish   159 KRMLHPKDSVQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLTNELYRFSLEGISSILFETRIG 223

  Fly   232 LLSDNPDPNADRLAKHMRDFFNYSFQFDVQPSIWTFYKTAGFKKFLKTYDNITDITSNYIETAMR 296
            .|..............:.....||......|: ||......:::::..:|.|.......|:..|.
Zfish   224 CLEKEIPAETQHFINSIAQMLTYSMPVVFMPN-WTRNYLPFWQRYIGGWDGIFKFAGKMIDMKME 287

  Fly   297 GFGKNDDGKTKCV---LEQLLEHNK---KVAVTMVMDMLMAGIDTTSSACLTILYHLARNPSKQE 355
            ...|..|...:..   |..||.:.|   |.....|.::|:||:||||:..|..||||:::|..|:
Zfish   288 ALQKRVDANQEVAGEYLTYLLSNGKMSSKDVYGSVSELLLAGVDTTSNTMLFALYHLSKDPETQD 352

  Fly   356 KLRRELLRILPTTKDSL--TDQNTKNMPYLRACIKEGLRITSITPGNFR-ITPKDLVLSGYQVPR 417
            .|.:|:..:|   ||..  |.|....|.||:|.|||.||:..:.|.|.| |...::|:.|:..|:
Zfish   353 ILYQEVTNVL---KDDRIPTAQEVNTMSYLKAVIKETLRLYPVVPMNARLIAENEVVIGGHLFPK 414

  Fly   418 GTGVLMGVLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAARTR-NPFVYLPFGFGPRTCIG 481
            .|...:....:|.|:|.|.:..:|.|||||:.           .||| |||..:|||||.|.|:|
Zfish   415 NTTFTLCHYAISRDEKVFPEPQKFKPERWLRD-----------GRTRPNPFGSIPFGFGVRGCVG 468

  Fly   482 KRIAELEIETLLVRLLRSYKV 502
            :||||||:...|.||::.:::
Zfish   469 RRIAELEMYLALARLIKLFEI 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	129/456 (28%)
cyp27a7	XP_002663445.1	p450	68..507	CDD:278495	127/447 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.780