DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12b2 and Cyp301a1

DIOPT Version :9

Sequence 1:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	168/531 - (31%)
Similarity:	282/531 - (53%)	Gaps:	35/531 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RNSSVGGTLSQQTQLELADS------RI--DEKWQQARSFGEIPGPSLLRMLS---FFMP-GGAL 74
            |.||.|    ..|...||||      ||  ..:||.|..:.:||||..:.:|.   ..|| .|..
  Fly    37 RESSTG----VATCPHLADSEEASAPRIHSTSEWQNALPYNQIPGPKPIPILGNTWRLMPIIGQY 97

  Fly    75 RNTNLIQMNRLMREMYGDIYCIPGMMGKPNAVFTYNPDDFEMTYRNEGVWPIRIGLESLNYYRKI 139
            ..:::.:::.|:.:.||.|....|::|:|:.:|.|:.|:.|..||:||..|.|..:.||..|:.:
  Fly    98 TISDVAKISSLLHDRYGRIVRFGGLIGRPDLLFIYDADEIEKCYRSEGPTPFRPSMPSLVKYKSV 162

  Fly   140 HRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKVQNVRQNLPQLDQISKEFIDKLETQRNPETHT 204
            .|.|.|..:||:....|:.|.:.|::|...::::..:|:.|..|:.|:::|:.:.|...: |...
  Fly   163 VRKDFFGDLGGVVGVHGEPWREFRSRVQKPVLQLSTIRRYLQPLEVITEDFLVRCENLLD-ENQE 226

  Fly   205 LTTDFHNQLKMWAFESISFVALNTRMGLLSDNPDPNADRLAKHMRDFFNYSFQ----FDVQPSIW 265
            |..||.|::..|:.|.|..|||:||:|.|..|..|:::  .:.:.|...|:.:    .:::...|
  Fly   227 LPEDFDNEIHKWSLECIGRVALDTRLGCLESNLKPDSE--PQQIIDAAKYALRNVATLELKAPYW 289

  Fly   266 TFYKTAGFKKFLKTYDNITDITSNYIETAMRGFGKNDD----GKTKCVLEQLL-EHNKKVAVTMV 325
            .::.|..:.:::|..:....:...||::|.......|.    |:...|.:.:| :.::|:|..|.
  Fly   290 RYFPTPLWTRYVKNMNFFVGVCMKYIQSATERLKTQDPSLRAGEPSLVEKVILSQKDEKIATIMA 354

  Fly   326 MDMLMAGIDTTSSACLTILYHLARNPSKQEKLRRELLRILPTTKDSLTDQNTKNMPYLRACIKEG 390
            :|:::.||||.|.|..::||.||..|..|:|:..||.|:||.....||......|.:|:..|||.
  Fly   355 LDLILVGIDTISMAVCSMLYQLATRPVDQQKVHEELKRLLPDPNTPLTIPLLDQMHHLKGFIKEV 419

  Fly   391 LRITSITPGNFRITPKDLVLSGYQVPRGTGVLMGVLELSNDDKYFAQSSEFIPERWLKSDLAPDI 455
            .|:.|...||.|...:|.|:.|||||:|...:...:...|.::|...::.|.||||||    |..
  Fly   420 FRMYSTVIGNGRTLMEDSVICGYQVPKGVQAVFPTIVTGNMEEYVTDAATFRPERWLK----PQH 480

  Fly   456 QACPAARTRNPFVYLPFGFGPRTCIGKRIAELEIETLLVRLLRSYKVSWLPETPIEYESTIILSP 520
            ...|.  ..:||..||:|:|.|.|:|:|.|:||::.||.:|||:||:.: ...|::|..|.:.:|
  Fly   481 GGTPG--KLHPFASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKLEY-NHKPLDYAVTFMYAP 542

  Fly   521 CGDIRFKLEPV 531
            .|.:|||:..|
  Fly   543 DGPLRFKMTRV 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	143/464 (31%)
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	144/463 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
	9	8.970