Protein Alignment Cyp12b2 and Cyp11b3

DIOPT Version :10

• Sequence 1: NP_611370.2
• Gene: Cyp12b2 / 37163
• FlyBaseID: FBgn0034387
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_861545.2
• Gene: Cyp11b3 / 353498
• RGDID: 727886
• Length: 498
• Species: Rattus norvegicus
• Alignment Length: 536
• Identity: 135/536 - (25%)
• Similarity: 245/536 - (45%)
• Gaps: 75/536 - (13%)

  Fly    19 W--FNRNSSVGGTLSQQTQ----LELADSRIDEKWQQARSFGEIPGPSLLRMLSFFMPGGALRNT 77
            |  .:|..::|.|.:|..:    .|........||              |:|:......|   ..
  Rat    14 WQCLHRTRALGSTATQAPKTLKPFEAIPQYSRNKW--------------LKMIQILREQG---QE 61

  Fly    78 NL-IQMNRLMREMYGDIYCIPGMMGKPNAVFTYNPDDFEMTYRNEGVWPIRIGLESLNYYRKIHR 141
            || ::|::..:|: |.|:  ....|....|....|:|.|..::.|.:.|.|:.|||...:|::.
  Rat    62 NLHLEMHQAFQEL-GPIF--RHSAGGAQIVSVMLPEDAEKLHQVESILPRRMTLESWVAHRELR- 122

  Fly   142 PDVFKGVGGLASDQGQEWADIRNKVNPVLMKVQNVRQNLPQLDQISKEFIDKLETQRNPETH-TL 205
             .:.:||..|   .|.:|...|.::||.::..:.|:..:|.:|.::::|::.|:.:.....| ::
  Rat   123 -GLRRGVFLL---NGADWRFNRLQLNPNMLSPKAVQSFVPFVDVVARDFVENLKKRMLENVHGSM 183

  Fly   206 TTDFHNQLKMWAFESISFVALNTRMGLLSDNPDPNADRLAKHMRDFFNYSFQFDVQP---SIWTF 267
            :.|..:.:..:..|:..||....|:||...:..|.:.:....:...|..:.|....|   :.||
  Rat   184 SMDIQSNVFNYTMEASHFVISGERLGLTGHDLKPESLKFIHALHSMFKSTTQLMFLPKNLTRWT- 247

  Fly   268 YKTAGFKKFLKTYDNITDITSNYIETAMRGFGKNDDGKTKCVLEQLLEHNKKVAVTMVMDM---- 328
             .|..:|...:::|.|::..:..|:...|...:........:.|.:.:.      |:.||.
  Rat   248 -STQVWKGHFESWDIISEYVTKCIKNVYRELAEGRQQSWSVISEMVAQS------TLSMDAIHAN 305

  Fly   329 ---LMAG-IDTTSSACLTILYHLARNPSKQEKLRRELL----RILPTTKDSLTDQNTKNMPYLRA 385
               |:|| :|||:.:.:..|:.|||||..|:.||:|.|    .|....:.:::|     :|.|||
  Rat   306 SMELIAGSVDTTAISLVMTLFELARNPDVQQALRQESLAAEASIAANPQKAMSD-----LPLLRA 365

  Fly   386 CIKEGLRITSITPGNFRITPKDLVLSGYQVPRGTGVLMGVLELSNDDKYFAQSSEFIPERWLKSD 450
            .:||.||:..|.....||...||||..|.||.||.|::.:..:..:...|.:...::|:|||:
  Rat   366 ALKETLRLYPIGSSLERIVDSDLVLQNYHVPAGTLVIIYLYSMGRNPAVFPRPERYMPQRWLE-- 428

  Fly   451 LAPDIQACPAARTRNPFVYLPFGFGPRTCIGKRIAELEIETLLVRLLRSYKVSWLPETPIEYEST 515
                       |.|: |.:|.||||.|.|:|:|:||:|:..||..:|:.::|..|.:..::....
  Rat   429 -----------RKRS-FQHLAFGFGVRQCLGRRLAEVEVLLLLHHMLKIFQVETLRQEDVQMAYR 481

  Fly   516 IILSPCGDIRFKLEPV 531
            .:|.|...:...:.||
  Rat   482 FVLMPNPRLVLTIRPV 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	CYP24A1-like	87..525	CDD:410677	119/453 (26%)
Cyp11b3	NP_861545.2	None