Protein Alignment Cyp12b2 and CYP27C1

DIOPT Version :10

• Sequence 1: NP_611370.2
• Gene: Cyp12b2 / 37163
• FlyBaseID: FBgn0034387
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_001354431.1
• Gene: CYP27C1 / 339761
• HGNCID: 33480
• Length: 537
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 143/515 - (27%)
• Similarity: 238/515 - (46%)
• Gaps: 84/515 - (16%)

  Fly    51 RSFGEIPGP-SLLRMLSFFMPGGALRNTNLIQMNRLMREMYGDIYCIPGMMGKPNAVFTYNPDDF 114
            ||...:||| :|..:..||...|..|...:.|.:  .|| ||.|:  ....|....|...:.|..
Human    64 RSLAAMPGPRTLANLAEFFCRDGFSRIHEIQQKH--TRE-YGKIF--KSHFGPQFVVSIADRDMV 123

  Fly   115 EMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKVQNVRQN 179
            ....|.||..|.|..:||...||     |:.....||.|.:|::|..:|:.:...::|.::|...
Human   124 AQVLRAEGAAPQRANMESWREYR-----DLRGRATGLISAEGEQWLKMRSVLRQRILKPKDVAIY 183

  Fly   180 LPQLDQISKEFIDKLETQRN-PETHTLTTDFHNQLKMWAFESISFVALNTRMGLLSDNPDPN--- 240
            ..:::|:..:.|.::...|: .|.....|:.::....::.|.::.:...:|:|.| :|..|.
Human   184 SGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCL-ENSIPQLTV 247

  Fly   241 ------------------ADRLAKHMRDFFNYSFQFDVQPSIWTFYKTAGFKKFLKTYDNITDIT 287
                              |..:.:.:|.|.         |..|        ::|.:::|.:...:
Human   248 EYIEALELMFSMFKTSMYAGAIPRWLRPFI---------PKPW--------REFCRSWDGLFKFS 295

  Fly   288 SNYIETAMRGF------GKNDDG--KTKCVLEQLLEHNKKVAVTMVMDMLMAGIDTTSSACLTIL 344
            ..:::..:|..      |:...|  .|...|.|.|...:..|  .|.:||:||:||||......:
Human   296 QIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYA--NVTEMLLAGVDTTSFTLSWTV 358

  Fly   345 YHLARNPSKQEKLRRELL-----RILPTTKDSLTDQNTKNMPYLRACIKEGLRITSITPGNFRIT 404
            |.|||:|..|:.:.||::     |.:||..|      ...:|.:||.:||.||:..:.|||.|:|
Human   359 YLLARHPEVQQTVYREIVKNLGERHVPTAAD------VPKVPLVRALLKETLRLFPVLPGNGRVT 417

  Fly   405 PKDLVLSGYQVPRGTGVLMGVLELSNDDKYFAQSSEFIPERWL-KSDLAPDIQACPAARTRNPFV 468
            .:|||:.||.:|:||.:.:.....|..|:.|.::.||.||||| |.||         .|..| |.
Human   418 QEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDL---------DRVDN-FG 472

  Fly   469 YLPFGFGPRTCIGKRIAELEIETLLVRLLRSYKVSWLPETPIEYESTI-ILSPCGDIRFK 527
            .:|||.|.|:|||:|||||||..::::||:.:::....:|...:..|. :|:|.|.|..:
Human   473 SIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVR 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	CYP24A1-like	87..525	CDD:410677	131/474 (28%)
CYP27C1	NP_001354431.1	CYP27C1	98..530	CDD:410740	131/475 (28%)