DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12b2 and Cyp28d1

DIOPT Version :9

Sequence 1:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	459	Identity:	112/459 - (24%)
Similarity:	186/459 - (40%)	Gaps:	76/459 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 MGKPNAVFT------YNPDDFEMTYRNE----GVWPIRIG---LESLNY--------YRKIHRPD 143
            :|...:|||      |:.|:....|:|.    ||:..||.   :.:..|        :|..|..:
  Fly    43 VGSFPSVFTQKRNVVYDIDEIYEQYKNTDSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNE 107

  Fly   144 VFKGVGG-----LASD----QGQEWADIRNKVNPVLMKVQNVRQNLPQLDQISKEFIDKLETQ-- 197
            :.|....     ||::    .|:.|.:.|.:|.|.| ....|:...|...::.|:|::.:..|
  Fly   108 MAKFTDSKTDPILANNPFVLTGEAWKERRAEVTPGL-SANRVKAAYPVSLRVCKKFVEYIRRQSL 171

  Fly   198 RNPETHTLTTDFHNQLKMWAFESISFVALNTRMGLLSDNPDP---NADRLAKHMRDFFNYSFQFD 259
            ..|.......|.   ...:..|.||...|.......:|||.|   ...|:.:....|..|:...:
  Fly   172 MAPAQGLNAKDL---CLCYTTEVISDCVLGISAQSFTDNPTPMVGMTKRVFEQSFGFIFYTVVAN 233

  Fly   260 VQPSIWTFYKTAGFKKFLKTYDNITDITSNYIETAMR--GFGKNDDGKTKCVLEQLLEHNKKVAV 322
            :.|.|..||..:.|.|.:..:  ..|:....|:....  ...:.||     .|..:|:..:|..:
  Fly   234 LWPPITKFYSVSLFAKDVAAF--FYDLMQKCIQVRRESPAAQQRDD-----FLNYMLQLQEKKGL 291

  Fly   323 ------TMVMDMLMAGIDTTSSACLTILYHLARNPSKQEKLRRELLRILPTTKDSLTDQNTKNMP 381
                  :..|..|..|.:||:......|..|||||.:|.|||.|:      ....||.:....:|
  Fly   292 NAAELTSHTMTFLTDGFETTAQVLTHTLLFLARNPKEQMKLREEI------GTAELTFEQISELP 350

  Fly   382 YLRACIKEGLRITS-------ITPGNFRITPKDLVLSGYQVPRGTGVLMGVLELSNDDKYFAQSS 439
            :..|||.|.|||.|       :......:|.|:.|  ..::..|..|::.|..|.:|.:|:.:..
  Fly   351 FTEACIHETLRIFSPVLAARKVVTEPCELTNKNGV--SVKLRPGDVVIIPVNALHHDPQYYEEPQ 413

  Fly   440 EFIPERWLKSDLAPDIQACPAARTRNPFVYLPFGFGPRTCIGKRIAELEIETLLVRLLRSYKVSW 504
            .|.|||:|..:..       |.:.|:..::..||.|||.|.|.|.:..:|:..||.::|::.:..
  Fly   414 SFKPERFLNINGG-------AKKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKV 471

  Fly   505 LPET 508
            .|:|
  Fly   472 NPKT 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	112/459 (24%)
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	112/459 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910