DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12b2 and cyp27a1.4

DIOPT Version :9

Sequence 1:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001315442.1	Gene:	cyp27a1.4 / 322341	ZFINID:	ZDB-GENE-030131-1060	Length:	522	Species:	Danio rerio

Alignment Length:	526	Identity:	128/526 - (24%)
Similarity:	241/526 - (45%)	Gaps:	65/526 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 YRNVSGNQLWFNRNSSVGGTLSQQTQLELADSRIDEKWQQARSFGEIPGPSLLRMLSFFMPGGAL 74
            :|..:||        |...::|           :.:..::.::..::|...:..||...:..|.|
Zfish    27 FRRAAGN--------SAAASVS-----------VQDGHRKLKTEADLPEIKIFTMLYQMLFKGYL 72

  Fly    75 RNTNLIQMNRLMREMYGDIYCIPGMMGKPNAVFTYNPDDFEMTYRNEGVWPIRIGLESLNYYRKI 139
            .:.:.:|:  ..:::||.::.|..  |....:...:.:..|...|.:..:|.|..:.....:|.:
Zfish    73 NSVHELQL--YQKQVYGPLWKINA--GNLQGISITSVELLEELLRKDEKYPCRGYMTLWTEHRDL 133

  Fly   140 HRPDVFKGVG-GLASDQGQEWADIRNKVNPVLMKVQNVRQNLPQLDQISKEFIDKLETQRN-PET 202
                  :|:. |..:::|::|..:|..:|..::..::..|....::.:..:||.::...|. ..|
Zfish   134 ------RGISYGPFTEEGEKWYKLRAVLNKRMLHPKDSLQYGDVVNAVITDFIKRIYYLREMSPT 192

  Fly   203 HTLTTDFHNQLKMWAFESISFVALNTRMGLLSDNPDPNADRLAKHMRDFFNYSFQFDVQPSIWTF 267
            ..|.::..|:|..::.|.|:.:...||:|.|..............:...|.|:....:.|: ||.
Zfish   193 GDLVSNLTNELYRFSLEGIASILFETRIGCLEKEIPAETQEFINSIAQMFTYNMHVALLPN-WTR 256

  Fly   268 YKTAGFKKFLKTYDNITDITSNYIETAMRGFGKNDDGKTKCV---LEQLLEHNK---KVAVTMVM 326
            .....::|::..:|.|....:..|...|.......|...:..   |..||...|   |.....|.
Zfish   257 NYLPFWQKYIDGWDGIFKFGTKMINLKMEAIQTRLDTNQEVAGEYLTYLLSSGKMSCKDVYGSVS 321

  Fly   327 DMLMAGIDTTSSACLTILYHLARNPSKQEKLRRELLRIL-----PTTKDSLTDQNTKNMPYLRAC 386
            ::|:||:||||:..|..||.|:::|:.||.|.:|:.::|     ||.::      ..:||:|:|.
Zfish   322 EVLLAGVDTTSNTMLWALYLLSKDPAAQETLHQEVTKVLKGDRIPTAEE------VNSMPFLKAV 380

  Fly   387 IKEGLRITSITPGNFR-ITPKDLVLSGYQVPRGTGVLMGVLELSNDDKYFAQSSEFIPERWLKSD 450
            |||.||:..:.|.|.| |...::::..|..|:.|...:....:|:|:|.|.:..:|.|||||:.
Zfish   381 IKETLRLYPVVPVNSRLIAESEVIIGEYLFPKKTTFNLFHYAISHDEKVFPEPQKFKPERWLRD- 444

  Fly   451 LAPDIQACPAARTR-NPFVYLPFGFGPRTCIGKRIAELEIETLLVRLLRSYKVSWLP---ETPIE 511
                      .||| |||..:|||||.|.|:|:||||||:...|.||::.:::...|   |....
Zfish   445 ----------GRTRPNPFGSIPFGFGVRACVGRRIAELEMHLALARLIKLFEMRPDPTVGEVKAN 499

  Fly   512 YESTII 517
            :.|.::
Zfish   500 FRSVLV 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	121/469 (26%)
cyp27a1.4	NP_001315442.1	p450	66..505	CDD:278495	120/466 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.780