DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12b2 and Cyp24a1

DIOPT Version :9

Sequence 1:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_963966.1	Gene:	Cyp24a1 / 25279	RGDID:	2462	Length:	514	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	134/502 - (26%)
Similarity:	233/502 - (46%)	Gaps:	59/502 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 QARSFGEIPGPS----LLRMLSFFMPGGALRNTNLIQMNRLMREMYGDIYCIPGMMGKPNAVFTY 109
            :.|:...:|||:    |..:|..|..||..:..:.:..   ..:.||.|:.:  .:|..::|...
  Rat    51 ETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAE---YHKKYGQIFRM--KLGSFDSVHLG 110

  Fly   110 NPDDFEMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKVQ 174
            :|...|..||.|...|.|:.::....||. ||.:.:    ||...:||||..:|:.....|||..
  Rat   111 SPSLLEALYRTESAHPQRLEIKPWKAYRD-HRNEAY----GLMILEGQEWQRVRSAFQKKLMKPV 170

  Fly   175 NVRQNLPQLDQISKEFIDKL-----ETQRNPETHTLTTDFHNQLKMWAFESISFVALNTRMGLLS 234
            .:.:...:::::..:|::::     |..|.|       |.:::|..|:||||..|....|.|||.
  Rat   171 EIMKLDKKINEVLADFLERMDELCDERGRIP-------DLYSELNKWSFESICLVLYEKRFGLLQ 228

  Fly   235 DNPDPNADRLAKHMRDFFNYSFQFDVQP---------SIWTFYKTAGFKKFLKTYDNITDITSNY 290
            ...:..|......::...:...:..|.|         .:|..:..|        :|.|.......
  Rat   229 KETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLA--------WDTIFKSVKPC 285

  Fly   291 IETAMRGFGKNDDGKTKCVLEQLLEHNKKVAVTMVMDMLMAGIDTTSSACLTILYHLARNPSKQE 355
            |:..::.:.:.......|.:.|....:||.....|.::.:|.::||:::.:.|||:|:|||..|.
  Rat   286 IDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQR 350

  Fly   356 KLRRELLRILPTTKDSLTD--QNTKNMPYLRACIKEGLRITSITPGNFRITPKDLVLSGYQVPRG 418
            :|.:|:..:||   |:.|.  ::.:|||||:||:||.:|:|...|...|...|..||..|.:|:|
  Rat   351 RLLQEVQSVLP---DNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKG 412

  Fly   419 TGVLMGVLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAARTRNPFVYLPFGFGPRTCIGKR 483
            |.:.:....|.:.:..|..|.:|.|||||:.:           :..|||.:||||.|.|.|||:|
  Rat   413 TVLTLNTQVLGSSEDNFEDSHKFRPERWLQKE-----------KKINPFAHLPFGIGKRMCIGRR 466

  Fly   484 IAELEIETLLVRLLRSYKVSWLPETPIEYESTIILSPCGDIRFKLEP 530
            :|||::...|..:::.|.:......|:|.....||.|..::.....|
  Rat   467 LAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRP 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	126/471 (27%)
Cyp24a1	NP_963966.1	CYP24A1	90..508	CDD:410738	124/453 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68094
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.770