DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12b2 and CYP27B1

DIOPT Version :9

Sequence 1:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_000776.1	Gene:	CYP27B1 / 1594	HGNCID:	2606	Length:	508	Species:	Homo sapiens

Alignment Length:	534	Identity:	133/534 - (24%)
Similarity:	230/534 - (43%)	Gaps:	58/534 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KYSNKIIYRNVSGNQLWFNRNSSVGGTLSQQTQLELADSRIDEKWQQARSFGEIPGPSLLRMLSF 67
            ||::::.:|     ..|   ...:|.:|..:           |.....||..:|||||....|:.
Human     6 KYASRVFHR-----VRW---APELGASLGYR-----------EYHSARRSLADIPGPSTPSFLAE 51

  Fly    68 FMPGGALRNTNLIQMNRLMREMYGDIYCIPGMMGKPNAVFTYNPDDFEMTYRNEGVWPIRIGLES 132
            ....|.|...:.:|:.....  :|.::.  ...|....|:...|...|...|.||..|.|.....
Human    52 LFCKGGLSRLHELQVQGAAH--FGPVWL--ASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSP 112

  Fly   133 LNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKVQNVRQNLPQLDQISKEFIDKLETQ 197
            ...:|:..     :...||.:.:|:||..:|:.:.|:|::.|...:....|:.:..:.:.:|..|
Human   113 WTEHRRCR-----QRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQ 172

  Fly   198 RNPET--HTLTTDFHNQLKMWAFESISFVALNTRMGLLSDNPDPNADRLAKHMRDFFNYSFQFDV 260
            |...|  ..|..|...:...:..|.|:.|.|.:|:|.|.....|:.:...:.:...|..:.....
Human   173 RGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMA 237

  Fly   261 QPSIWTFYKTAG-FKKFLKTYDNITDITSNYI-----ETAMRGFGKND-DGKTKCVLEQLLEHNK 318
            .|. |..:...| :.:..:.:|.:......::     |.|||..|:.: |.::...|...|...:
Human   238 MPH-WLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREE 301

  Fly   319 KVAVTM---VMDMLMAGIDTTSSACLTILYHLARNPSKQEKLRRELLRILPTTKDSLTDQNT-KN 379
            ..|.::   |.::|:||:||.|:.....||.|:|:|..|..|..|:...|.....:...... ..
Human   302 LPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366

  Fly   380 MPYLRACIKEGLRITSITPGNFRITPKDLVLSGYQVPRGTGVLMGVLELSNDDKYFAQSSEFIPE 444
            :|.|:|.:||.||:..:.|||.|:..||:.:..|.:|:.|.|.:.....|.|...|.:.:.|.|.
Human   367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPA 431

  Fly   445 RWLKSDLAPDIQACPAARTRNPFVYLPFGFGPRTCIGKRIAELEIETLLVRLLRSYKVSWLPE-- 507
            |||.....|           :||..||||||.|:|:|:|:||||::..|.::|..::|.  ||
Human   432 RWLGEGPTP-----------HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ--PEPG 483

  Fly   508 -TPIEYESTIILSP 520
             .|:..::..:|.|
Human   484 AAPVRPKTRTVLVP 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	119/467 (25%)
CYP27B1	NP_000776.1	p450	41..505	CDD:278495	123/480 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	1	0.950	-	0	Normalized mean entropy	S4820
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.830