Protein Alignment Cyp12b2 and CYP11B1

DIOPT Version :9

• Sequence 1: NP_611370.2
• Gene: Cyp12b2 / 37163
• FlyBaseID: FBgn0034387
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_000488.3
• Gene: CYP11B1 / 1584
• HGNCID: 2591
• Length: 503
• Species: Homo sapiens
• Alignment Length: 480
• Identity: 134/480 - (27%)
• Similarity: 224/480 - (46%)
• Gaps: 49/480 - (10%)

  Fly    57 PGPSLLRMLSFFMPGGALRNTNLIQMNRLMREMYGDIYCIPGMMGKPNAVFTYNPDDFEMTYRNE 121
            ||...||:|..:...| ..:.:| ::::..:|: |.|:...  :|....|....|:|.|...:.:
Human    45 PGNRWLRLLQIWREQG-YEDLHL-EVHQTFQEL-GPIFRYD--LGGAGMVCVMLPEDVEKLQQVD 104

  Fly   122 GVWPIRIGLESLNYYRKIHRPDVFKGVG---GLASDQGQEWADIRNKVNPVLMKVQNVRQNLPQL 183
            .:.|.|:.||....||: ||       |   |:....|.||...|.::||.::....|::.||.:
Human   105 SLHPHRMSLEPWVAYRQ-HR-------GHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMV 161

  Fly   184 DQISKEFIDKLETQ--RNPETHTLTTDFHNQLKMWAFESISFVALNTRMGLLSDNPDPNADRLAK 246
            |.::::|...|:.:  :|.. .:||.|....:..:..|:.:......|:||:..:|...:.....
Human   162 DAVARDFSQALKKKVLQNAR-GSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLH 225

  Fly   247 HMRDFFNYSFQFDVQP---SIWTFYKTAGFKKFLKTYDNITDITSNYIETAMR--GFGKNDDGKT 306
            .:...|..:.|....|   |.||..|.  :|:..:.:|.|.....|.|:...:  .|.:... .|
Human   226 ALEVMFKSTVQLMFMPRSLSRWTSPKV--WKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQ-YT 287

  Fly   307 KCVLEQLLEHNKKVAVTMV----MDMLMAGIDTTSSACLTILYHLARNPSKQEKLRRELLRILPT 367
            ..|.|.||  |.:::...:    |::....:|||....|..|:.|||||:.|:.||:|.|....:
Human   288 SIVAELLL--NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAAS 350

  Fly   368 TKDSLTDQNTKNMPYLRACIKEGLRITSITPGNF--RITPKDLVLSGYQVPRGTGVLMGVLELSN 430
            ..:. ..:.|..:|.|||.:||.||:..:  |.|  |:...||||..|.:|.||.|.:.:..|..
Human   351 ISEH-PQKATTELPLLRAALKETLRLYPV--GLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGR 412

  Fly   431 DDKYFAQSSEFIPERWLKSDLAPDIQACPAARTRNPFVYLPFGFGPRTCIGKRIAELEIETLLVR 495
            :...|.:...:.|:|||      ||:    ...|| |.::|||||.|.|:|:|:||.|:..||..
Human   413 NPALFPRPERYNPQRWL------DIR----GSGRN-FYHVPFGFGMRQCLGRRLAEAEMLLLLHH 466

  Fly   496 LLRSYKVSWLPETPIEYESTIILSP 520
            :|:..:|..|.:..|:...:.||.|
Human   467 VLKHLQVETLTQEDIKMVYSFILRP 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	128/467 (27%)
CYP11B1	NP_000488.3	p450	42..454	CDD:365848	121/441 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820