Protein Alignment Cyp12b2 and CYP11A1

DIOPT Version :10

• Sequence 1: NP_611370.2
• Gene: Cyp12b2 / 37163
• FlyBaseID: FBgn0034387
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_000772.2
• Gene: CYP11A1 / 1583
• HGNCID: 2590
• Length: 521
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 139/496 - (28%)
• Similarity: 225/496 - (45%)
• Gaps: 66/496 - (13%)

  Fly    51 RSFGEIPGP---SLLRMLSFFMPGGALRNTNLIQMNRLMR-EMYGDIYCIPGMMGKPNAVFTYNP 111
            |.|.|||.|   ..|.:..|:...|    |:.:.::.:.. :.||.||  ...:|...:|:..:|
Human    46 RPFNEIPSPGDNGWLNLYHFWRETG----THKVHLHHVQNFQKYGPIY--REKLGNVESVYVIDP 104

  Fly   112 DDFEMTYRNEGVWPIRIGLES-LNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKVQN 175
            :|..:.:::||..|.|..:.. :.|::...||.      |:...:...|...|..:|..:|..:.
Human   105 EDVALLFKSEGPNPERFLIPPWVAYHQYYQRPI------GVLLKKSAAWKKDRVALNQEVMAPEA 163

  Fly   176 VRQNLPQLDQISKEFIDKLETQ-RNPETHTLTTDFHNQLKMWAFESISFVALNTRMGLLSDNPDP 239
            .:..||.||.:|::|:..|..: :...:...:.|..:.|..:|||||:.|....|.|:|.:..:|
Human   164 TKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNP 228

  Fly   240 NADRLAKHMRDFFNYSF-QFDVQPSIWTFYKTAGFKKFLKTYDNI---TDI-TSN-YIETAMRGF 298
            .|.|....:...|:.|. ..::.|.::..::|..:|..:..:|.|   .|| |.| |.|...:|.
Human   229 EAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGS 293

  Fly   299 GKNDDGKTKCVLEQLLEHNK------KVAVTMVMDMLMAGIDTTSSACLTILYHLARNPSKQEKL 357
            ..:|   .:.:|.:||..:|      |..||   :||..|:||||......||.:|||...|:.|
Human   294 VHHD---YRGILYRLLGDSKMSFEDIKANVT---EMLAGGVDTTSMTLQWHLYEMARNLKVQDML 352

  Fly   358 RRELLRILPTTKDSLTDQNT--KNMPYLRACIKEGLRITSITPGNFRITPKDLVLSGYQVPRGTG 420
            |.|   :|.....:..|..|  :.:|.|:|.|||.||:..|:....|....||||..|.:|..|.
Human   353 RAE---VLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTL 414

  Fly   421 VLMGVLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAARTRNPFVYLPFGFGPRTCIGKRIA 485
            |.:.:..|..:..:|.....|.|.|||..|           :....|..|.||:|.|.|:|:|||
Human   415 VQVAIYALGREPTFFFDPENFDPTRWLSKD-----------KNITYFRNLGFGWGVRQCLGRRIA 468

  Fly   486 ELEIETLLVRLLRSYKVS--------------WLPETPIEY 512
            |||:...|:.:|.:::|.              .:||.||.:
Human   469 ELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISF 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	CYP24A1-like	87..525	CDD:410677	129/457 (28%)
CYP11A1	NP_000772.2	CYP11A1	82..508	CDD:410736	128/453 (28%)