DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12b2 and Cyp24a1

DIOPT Version :9

Sequence 1:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_034126.1	Gene:	Cyp24a1 / 13081	MGIID:	88593	Length:	514	Species:	Mus musculus

Alignment Length:	494	Identity:	134/494 - (27%)
Similarity:	232/494 - (46%)	Gaps:	55/494 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 QARSFGEIPGPS----LLRMLSFFMPGGALRNTNLIQMNRLMREMYGDIYCIPGMMGKPNAVFTY 109
            :.|:...:|||:    |..:|..|..||..:..:.:..   ..:.||.|:.:  .:|..::|...
Mouse    51 ETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAE---YHKKYGQIFRM--KLGSFDSVHLG 110

  Fly   110 NPDDFEMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKVQ 174
            :|...|..||.|...|.|:.::....||. ||.:.:    ||...:||||..:|:.....|||..
Mouse   111 SPSLLEALYRTESAHPQRLEIKPWKAYRD-HRNEAY----GLMILEGQEWQRVRSAFQKKLMKPV 170

  Fly   175 NVRQNLPQLDQISKEF---IDKLETQRNPETHTLTTDFHNQLKMWAFESISFVALNTRMGLLSDN 236
            .:.:...:::::..:|   ||:|..:|.     ...|.:::|..|:||||..|....|.|||..:
Mouse   171 EIMKLDKKINEVLADFMGQIDELRDERG-----RIQDLYSELNKWSFESICLVLYEKRFGLLQKD 230

  Fly   237 PDPNADRLAKHMRDFFNYSFQFDVQP---------SIWTFYKTAGFKKFLKTYDNITDITSNYIE 292
            .:..|......::...:...:..|.|         .:|..:..|        :|.|.......|:
Mouse   231 TEEEALTFIAAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLA--------WDTIFKSVKPCID 287

  Fly   293 TAMRGFGKNDDGKTKCVLEQLLEHNKKVAVTMVMDMLMAGIDTTSSACLTILYHLARNPSKQEKL 357
            ..:..:.:.......|.:.|....:||.....|.::.:|.::||:::.:.|||:|:|||..|::|
Mouse   288 HRLERYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQRL 352

  Fly   358 RRELLRILPTTKDSLTD--QNTKNMPYLRACIKEGLRITSITPGNFRITPKDLVLSGYQVPRGTG 420
            .||:..:||   |:.|.  ::.:|||||:||:||.:|:|...|...|...|..||..|.:|:||.
Mouse   353 LREIQSVLP---DNQTPRAEDVRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYTLPKGTV 414

  Fly   421 VLMGVLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAARTRNPFVYLPFGFGPRTCIGKRIA 485
            :.:....|.:.:..|..:.:|.|||||:.:           :..|||.:||||.|.|.|||:|:|
Mouse   415 LTLNTQVLGSSEDNFEDADKFRPERWLEKE-----------KKINPFAHLPFGVGKRMCIGRRLA 468

  Fly   486 ELEIETLLVRLLRSYKVSWLPETPIEYESTIILSPCGDI 524
            ||::...|..:::.|.:......|:|.....||.|..::
Mouse   469 ELQLHLALCWIIQKYNIVATDSEPVEMLHLGILVPSREL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	127/469 (27%)
Cyp24a1	NP_034126.1	p450	59..513	CDD:278495	133/486 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3255
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68094
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3800
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770