Protein Alignment Cyp12b2 and cyp27a1.2

DIOPT Version :10

• Sequence 1: NP_611370.2
• Gene: Cyp12b2 / 37163
• FlyBaseID: FBgn0034387
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: XP_031749759.1
• Gene: cyp27a1.2 / 116407844
• XenbaseID: XB-GENE-29093451
• Length: 546
• Species: Xenopus tropicalis
• Alignment Length: 498
• Identity: 142/498 - (28%)
• Similarity: 249/498 - (50%)
• Gaps: 36/498 - (7%)

  Fly    44 DEKWQQARSFGEIPGPSLLRMLSFFMPGGALRNTNLIQMNRLMREMYGDIYCIPGMMGKPNAVFT 108
            :||  :.::|.::||||||..:.:....|.:..|:  ::..:.::.||.::  ...:|:...|..
 Frog    67 EEK--KMKTFEDLPGPSLLTNIYWVFLRGYILYTH--ELQAIYKKNYGPMW--KSTLGRYKTVNI 125

  Fly   109 YNPDDFEMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKV 173
            .:.|..|...|.||.:|:||.:|....:|:  :.|:..|.   .:::|.:|..:|:.:|..::|.
 Frog   126 ADVDILETVLRQEGKYPVRIDMEVWKEHRR--QRDLSLGP---FTEEGHKWHTLRSVLNKRMLKP 185

  Fly   174 QNVRQNLPQLDQISKEFIDKLETQRNPETHT--LTTDFHNQLKMWAFESISFVALNTRMGLLSDN 236
            .........::::..:|:.:||..|: ||.:  :..|..|.|..:|||.||::...||:|.|...
 Frog   186 AEAMLYTGVVNEVVTDFLVRLEEMRS-ETPSGDMVNDIPNALYRFAFEGISYILFETRIGCLEKQ 249

  Fly   237 PDPNADRLAKHMRDFF-NYSFQFDVQPSIWTFYKTAGFKKFLKTYDNITDITSNYIETAMRGFG- 299
            ......|....:.... ||.|...:.|  ||......:|:::.::|||....:..|...|:...
 Frog   250 IPVETQRFIDSIGAMLKNYIFVTILPP--WTNNLLPYYKRYMDSWDNIFAFGNKLINEKMKKIEA 312

  Fly   300 --KNDDGKTKCVLEQLLEHNK---KVAVTMVMDMLMAGIDTTSSACLTILYHLARNPSKQEKLRR 359
              :.|:......|..|:...|   |.....|.::|:||:||||:.....||||||.|..|..|.:
 Frog   313 RLERDEEVQGEYLTYLISSGKLTDKEIYGSVAELLLAGVDTTSNTLSWALYHLAREPEIQNALYQ 377

  Fly   360 ELLRILPTTKDSLTDQNTKNMPYLRACIKEGLRITSITPGNFRI-TPKDLVLSGYQVPRGTGVLM 423
            |::.::| .::..|.::..:||.|||.|||.||:..:.|.|.|: ..|.:.:..|..|:.|.:.:
 Frog   378 EVIGVVP-GQNIPTSEDISSMPLLRAVIKETLRLYPVVPTNSRVAVEKAITIGDYYFPKDTLIAL 441

  Fly   424 GVLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAARTRNPFVYLPFGFGPRTCIGKRIAELE 488
            ....:|.|:|.|.:|.:|||:||.:.....:          |||..:|||:|.|.|:|:||||||
 Frog   442 HHYHISRDEKNFPESDKFIPQRWFRESRVKN----------NPFSSIPFGYGVRACVGRRIAELE 496

  Fly   489 IETLLVRLLRSYKVSWLPE-TPIEYESTIILSPCGDIRFKLEP 530
            :...|.|:::.|:|...|. ..|:..:.|:|:|...|..:..|
 Frog   497 MHMCLSRIIKKYEVRPDPSGAEIKSMARIVLTPHKPINLQFLP 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	CYP24A1-like	87..525	CDD:410677	129/448 (29%)
cyp27a1.2	XP_031749759.1	cytochrome_P450	106..535	CDD:477761	130/449 (29%)