DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12b2 and Cyp27b1

DIOPT Version :9

Sequence 1:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_446215.1	Gene:	Cyp27b1 / 114700	RGDID:	69192	Length:	501	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	140/490 - (28%)
Similarity:	226/490 - (46%)	Gaps:	47/490 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RSFGEIPGPSLLRMLSFFMPGGALRNTNLIQMNRLMREMYGDIYCIPGMMGKPNAVFTYNPDDFE 115
            ||..:|||||....|:.....|.|...:.:|::...|  ||.|:  .|..|....|:..:|...|
  Rat    28 RSLSDIPGPSTPSFLAELFCKGGLSRLHELQVHGAAR--YGPIW--SGSFGTLRTVYVADPALVE 88

  Fly   116 MTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKVQNVRQNL 180
            ...|.|...|.|....|.:.:|:.|:    :..|.|.:| |:||..:|:.:.|:|::.|......
  Rat    89 QLLRQESHCPERCSFSSWSEHRRRHQ----RACGLLTAD-GEEWQRLRSLLAPLLLRPQAAAGYA 148

  Fly   181 PQLDQISKEFIDKLETQRN-----PETHTLTTDFHNQLKMWAFESISFVALNTRMGLLSDNPDPN 240
            ..||.:..:.:.:|..||.     |:   |..|...:...:..|.|..|.|.:|:|.|.....|:
  Rat   149 GTLDSVVSDLVRRLRRQRGRGSGLPD---LVLDVAGEFYKFGLEGIGAVLLGSRLGCLEAEVPPD 210

  Fly   241 ADRLAKHMRDFFNYSFQFDVQPSIWTFYKTAG-FKKFLKTYDNITDITSNYI-----ETAMRGFG 299
            .:...:.:...|..:......|| |......| :.:..:.:|.:......::     |.|:|..|
  Rat   211 TETFIEAVGSVFVSTLLTMAMPS-WLHRLIPGPWARLCRDWDQMFAFAQKHVEQREGEAAVRNQG 274

  Fly   300 K-NDDGKTKCVLEQLLEHNKKVAVTMVM----DMLMAGIDTTSSACLTILYHLARNPSKQEKLRR 359
            | .:|..|...|...| ..:||:|..::    ::|:||:||.|:.....||.|:|:|..|..|..
  Rat   275 KPEEDLPTGHHLTHFL-FREKVSVQSIVGNVTELLLAGVDTVSNTLSWALYELSRHPEVQSALHS 338

  Fly   360 ELL-RILPTTKDSLTDQNTKNMPYLRACIKEGLRITSITPGNFRITPKDLVLSGYQVPRGTGVLM 423
            |:. .:.|.:...|.......:|.|:|.|||.||:..:.|||.|:..:|:.:..|.:|:.|.|.:
  Rat   339 EITGAVNPGSYAHLQATALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDICVGNYVIPQDTLVSL 403

  Fly   424 GVLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAARTRNPFVYLPFGFGPRTCIGKRIAELE 488
            .....|.|...|.:.:.|.|.|||....||           :||..||||||.|:|||:|:||||
  Rat   404 CHYATSRDPAQFREPNSFNPARWLGEGPAP-----------HPFASLPFGFGKRSCIGRRLAELE 457

  Fly   489 IETLLVRLLRSYKVSWLPE---TPIEYESTIILSP 520
            ::..|.::|..::|  |||   .|::..:..:|.|
  Rat   458 LQMALAQILTHFEV--LPEPGALPVKPMTRTVLVP 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	133/471 (28%)
Cyp27b1	NP_446215.1	CYP27B1	61..496	CDD:410741	129/457 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3026
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.880