DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JAK1 and jak1

DIOPT Version :9

Sequence 1:	NP_001307852.1	Gene:	JAK1 / 3716	HGNCID:	6190	Length:	1154	Species:	Homo sapiens
Sequence 2:	XP_002931642.1	Gene:	jak1 / 100038172	XenbaseID:	XB-GENE-483750	Length:	1142	Species:	Xenopus tropicalis

Alignment Length:	1144	Identity:	885/1144 - (77%)
Similarity:	1004/1144 - (87%)	Gaps:	8/1144 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    13 MAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNL 77
            ||||||||:|||.||.:.|.: |:|:.|||.|:..|....||:|||:|||.:|..|.||||||||
Frog     1 MAFCAKMRNSKKLEVGIAAKD-GLEICFYLPDKSTLYHLQGEFTAEDLCIESALHCNISPLCHNL 64

Human    78 FALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKK 142
            ||||:|.::.||:||....:|..:||:|||||||.||||||||:||.|||||.||| ::||:||:
Frog    65 FALYNERSQSWYSPNHNFKIDSNVSLKLHYRMRFIFTNWHGTNENEPSVWRHYPKK-RDGYDKKQ 128

Human   143 IPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQ 207
            |.:.|||||||||:||||||||:|||||||:|:||.:|:.|:|||||||||||||||||:.:.:|
Frog   129 IQEGTPLLDASSLDYLFAQGQYELVKCLAPVREPKNDQEVHEIENECLGMAVLAISHYAIKRNIQ 193

Human   208 LPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLA 272
            ||:||||||||:|||||||::|:|||.|||||||||||:||||||||||||||||.||||||||:
Frog   194 LPDLPKDISYKKYIPETLNRTIKQRNFLTRMRINNVFKNFLKEFNNKTICDSSVSPHDLKVKYLS 258

Human   273 TLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKE 337
            |:|||||:||||.|||:.|:|.||||.|.|:.:|..::..|||:||||.|||||.||...:.||:
Frog   259 TMETLTKNYGAESFETNSLIIKSENEQNGFNISDYDSMRRYEVLVTGNSGIQWRRKPTCTTSEKD 323

Human   338 KNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEA 402
            : ||||||.|:|.|..:||.|:::|||.|||:||||||.|||..|.||.||||.|||||||.|||
Frog   324 R-KLKRKKTESKSKNSDEKGKLKDEWNCFSYYPEITHIAIKEDTVIINNQDNKSMELKLSSQEEA 387

Human   403 LSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRW 467
            |||.:|:|||||||||||||||:||||||||:||:||||||||||||||||||||:|||||||||
Frog   388 LSFAALIDGYFRLTADAHHYLCSDVAPPLIVNNIKNGCHGPICTEYAINKLRQEGNEEGMYVLRW 452

Human   468 SCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILR 532
            |||||:||||||:|.:.|:......||:|||||||:||||||.|.||.|.||.|||.|||.|:|:
Frog   453 SCTDFNNILMTVSCSKMSQFESKYVKQYKNFQIEVKKGRYSLLGPDRGFDSLKDLMKHLKGQVLK 517

Human   533 TDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHI 597
            ||::||.||:||.||||||||||||||||.||||||.:|||||.||||:::.|.|||||||||.|
Frog   518 TDDVSFTLKKCCPPKPREISNLLVATKKALEWQPVYHLSQLSFHRILKEEITQLEHLGRGTRTQI 582

Human   598 YSGTLMDYKDD---EGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVR 659
            |:|.| :||||   |..|.||:|||||||||||||||||||||.|||||||||||||.|:|||||
Frog   583 YAGKL-NYKDDNDSESYSTEKEIKVILKVLDPSHRDISLAFFETASMMRQVSHKHIVLLHGVCVR 646

Human   660 DVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAR 724
            |||||||||||:.|||||||||||:|||||||||||||||||||||||||||||||||||:||||
Frog   647 DVENIMVEEFVDFGPLDLFMHRKSEVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNILLAR 711

Human   725 EGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYN 789
            ||||::|||||||||||||||||:|||.:||||||||||||||:.||||||||||||||||||:|
Frog   712 EGIDNDCGPFIKLSDPGIPITVLTRQERVERIPWIAPECVEDSRVLSVAADKWSFGTTLWEICFN 776

Human   790 GEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPD 854
            ||:||||:||.||||||......|.|||||||||:.:||||||.:|||||||||:||||||||||
Frog   777 GEVPLKDRTLAEKERFYGGCFMLVAPSCKELADLINQCMNYDPLRRPFFRAIMREINKLEEQNPD 841

Human   855 IVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHI 919
            |||||.|:.|||||.||||||||:|||||||||||||||||||||||||.||||||||.:.|:||
Frog   842 IVSEKTPSAEVDPTLFEKRFLKRVRDLGEGHFGKVELCRYDPEGDNTGELVAVKSLKPGTAGSHI 906

Human   920 ADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYA 984
            ||||||||||||||||||||||||| ||||:|||||||:|||||||||||:|.||||||||||||
Frog   907 ADLKKEIEILRNLYHENIVKYKGIC-EDGGSGIKLIMEYLPSGSLKEYLPRNVNKINLKQQLKYA 970

Human   985 VQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYA 1049
            .|||||||||||||||||||||||||||:|..:|||||||||||||||||||||||.||||||||
Frog   971 TQICKGMDYLGSRQYVHRDLAARNVLVENEQIIKIGDFGLTKAIETDKEYYTVKDDLDSPVFWYA 1035

Human  1050 PECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRL 1114
            ||||:..|||||||||||||||:||||||:|:.|||.:||||||||.|||||||||..|:|.|||
Frog  1036 PECLLHCKFYIASDVWSFGVTLYELLTYCNSEYSPMTMFLKMIGPTQGQMTVTRLVRVLEEDKRL 1100

Human  1115 PCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
            |.|.|||.:|||||.||||..||:||:||:||:||||::
Frog  1101 PIPANCPKQVYQLMLKCWEQNPSHRTTFQDLIKGFEAII 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JAK1	NP_001307852.1	B41	37..286	CDD:214604	179/248 (72%)
		FERM_C_JAK1	282..426	CDD:275412	94/143 (66%)
		SH2	426..527	CDD:301589	77/100 (77%)
		PTK_Jak1_rpt1	583..846	CDD:270662	219/265 (83%)
		Pkinase_Tyr	583..845	CDD:285015	219/264 (83%)
		PTKc_Jak1_rpt2	870..1153	CDD:173644	240/282 (85%)
		TyrKc	875..1149	CDD:197581	231/273 (85%)
jak1	XP_002931642.1	FERM_F1	23..116	CDD:375805	56/92 (61%)
		FERM_F2	133..263	CDD:375803	105/129 (81%)
		FERM_C_JAK1	268..411	CDD:275412	94/143 (66%)
		SH2_Jak1	411..512	CDD:198241	77/100 (77%)
		PTK_Jak1_rpt1	568..833	CDD:270662	219/265 (83%)
		PTKc_Jak1_rpt2	857..1139	CDD:173644	240/282 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	478	1.000	Domainoid score	I4153
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1678
Inparanoid	1	1.050	1817	1.000	Inparanoid score	I880
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47769
OrthoDB	1	1.010	-	-		D31031at32523
OrthoFinder	1	1.000	-	-		FOG0001105
OrthoInspector	1	1.000	-	-		oto148141
Panther	1	1.100	-	-	LDO	PTHR45807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9542
SonicParanoid	1	1.000	-	-		X669
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110