Protein Alignment List and SLC6A5

DIOPT Version :9

• Sequence 1: NP_611364.2
• Gene: List / 37157
• FlyBaseID: FBgn0034381
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_004202.4
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 217/593 - (36%)
• Similarity: 327/593 - (55%)
• Gaps: 55/593 - (9%)

  Fly     7 SKKSEKPAEKPAE-QWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRP 70
            :::.|:..|..|. .|.:.|:|:.|.:..:|||||:|||||:|||||||.|:||||:.|.:.|.|
Human   179 TQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLP 243

  Fly    71 VYYLEISLGQFTGRGVVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPW 135
            :::||:|||||..:|.|..:...|.|:|..:..::.:.....||:.|:..||.:..|||.|.|||
Human   244 IFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPW 308

  Fly   136 SRCWESWGT-DCHDG----------------------------------NAQNSSGK--MSPAQL 163
            ..|...|.| :|.|.                                  |..:.:.|  :|.::.
Human   309 GSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEE 373

  Fly   164 YFEREILHEVPNIDNGLSLP---NWQLVACLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLL 225
            ||:..:|    .|..|:..|   .|.|..||.:||:::...|.:|||:|||..||...||||||:
Human   374 YFKYFVL----KISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLV 434

  Fly   226 ILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVY 290
            |||:|.||||||..||.||..|:|.:|.:..||..|.||:||||:..:|.|||.:|||.|:.|.|
Human   435 ILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCY 499

  Fly   291 NDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQM 355
            .|.:|:|..:|.:||.||.:.|.::|.:|.|. ..:|.:|...|.|:||:.||||:.:....| .
Human   500 RDTLIVTCTNSATSIFAGFVIFSVIGFMANER-KVNIENVADQGPGIAFVVYPEALTRLPLSP-F 562

  Fly   356 FAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFG--LRS-PPIWKLASGLTVLGFSVSIVYMTPGG 417
            :|::|||||..||:.:.......|:..|.|:|.  ||: .|::.|  |..:..|.:....:|.||
Human   563 WAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTL--GCCICFFIMGFPMITQGG 625

  Fly   418 QFILNLVDFYGVSFTALILAIGELVAVAWIYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMT 482
            .::..|||.|..|:..:|:||.|||.::::||:.||||||:.|:|.:...:|::||.|:||.::|
Human   626 IYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILT 690

  Fly   483 AVLIYMLLDMSALEYKGVGYPTLAHVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAAC 547
            .:|.:.......:.|....||..:.|.|..:....:|.:|   |..:.|.....|.|.:|::..|
Human   691 FILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIP---IMFVIKMHLAPGRFIERLKLVC 752

  Fly   548 KPSDTWGP 555
            .|...|||
Human   753 SPQPDWGP 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	197/513 (38%)
SLC6A5	NP_004202.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..118
		SLC6sbd_GlyT2	191..787	CDD:271389	214/581 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920