DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and Slc6a2

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_112633.2	Gene:	Slc6a2 / 83511	RGDID:	621822	Length:	617	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	199/549 - (36%)
Similarity:	304/549 - (55%)	Gaps:	19/549 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLGQ 80
            :|.|.||..::||.|.:..:|.|.|:|||||:.::||||.|:|||.:.|::.|.|::|:|::|||
  Rat    54 QPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQ 118

  Fly    81 FTGRGVVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESWGT- 144
            |...|....:.:.|..|||....:|.......||:.|:|.:|.:..|||...|||:.|..:|.:
  Rat   119 FNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSP 183

  Fly   145 DCHDGNAQNSS----------GKMSPAQLYFEREI--LHEVPNIDNGLSLPNWQLVACLAIAWLV 197
            :|.|....|:|          .|.:||..::||.:  |||...| :.:.||.|||:.||.:..:|
  Rat   184 NCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGI-HDIGLPQWQLLLCLMVVIVV 247

  Fly   198 IGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAV 262
            :...|.:|:|:|||..:.....||.||.:||:..||||||.:||..:....:..|....||..|.
  Rat   248 LYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAA 312

  Fly   263 TQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDI 327
            ||:||||...||.||.:||||.|:.|.|.|.::.:|::..:|.|:|...|.|||.:|.| ....|
  Rat   313 TQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHE-HKVKI 376

  Fly   328 GSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFGLRSP 392
            ..|...||||.|:.|||||:... ....:||||||||..||:.|::|....::..:.|.|.:...
  Rat   377 EDVATEGAGLVFVLYPEAISTLS-GSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKR 440

  Fly   393 PIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGELVAVAWIYGVNRFCEDI 457
            ........:|:..|.:::..:|.||.::|.|:|.:....:.|...:.|.:.|:|.|||:||..||
  Rat   441 HRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDI 505

  Fly   458 KFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVGYPTLAHVFGCFLATLGLIQLP 522
            :.|||.:.|.||||||:|::|..:..|::..:::...|.|....||..|:..|..:|...:|.:|
  Rat   506 QQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVP 570

  Fly   523 GWAIYAIYKKRGHNGSFWQRIRAACKPSD 551
            .:.||..:..|   ||.|:|:.....|.:
  Rat   571 AYVIYKFFSIR---GSLWERVAYGITPEN 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	181/482 (38%)
Slc6a2	NP_112633.2	SLC5-6-like_sbd	56..615	CDD:382020	198/547 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820