DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment List and slc6a3

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_571830.1	Gene:	slc6a3 / 80787	ZFINID:	ZDB-GENE-010316-1	Length:	629	Species:	Danio rerio

Alignment Length:	544	Identity:	203/544 - (37%)
Similarity:	314/544 - (57%)	Gaps:	15/544 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEIS 77
            |:.:..|.||..::||.|.|..:|.|.|:|||||:.::||||.|::|||:.:::.|.|::|:|::
Zfish    71 PSGQQRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELA 135

  Fly    78 LGQFTGRGVVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESW 142
            |||:...|....:.:.|:.|||....:|.:....:||:.|:|..|.:..:||..||||..|..:|
Zfish   136 LGQYNREGAAGVWKICPIFKGVGFTVILISLYVGSYYNVIIAWALFYLFSSFSGELPWIHCNNTW 200

  Fly   143 GT-DCHDGNAQ--NSSGKMSPAQLYFEREIL--HEVPNIDNGLSLPNWQLVACLAIAWLVIGGVL 202
            .: :|.|.||.  |.:.|.:||..||||.:|  ||...||: |..|.|||.||||:..:|:...|
Zfish   201 NSPNCSDPNATLLNDTYKTTPALEYFERGVLHVHESSGIDD-LGAPRWQLTACLAVVIVVLYFSL 264

  Fly   203 IRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQVFF 267
            .:|:|:|||..:.....|||||.:||||.||||||||||..:....:..|.:..||..|.||:.|
Zfish   265 WKGVKTSGKVVWITATMPYVVLTVLLLRGVTLPGAIDGIKAYLSVDFLRLYDAQVWIEAATQICF 329

  Fly   268 SLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDIGSVVK 332
            ||.:.||.||.::|||.|:.|.|.|.:|.::::|.:|..:|.:.|..||.:::: .|..:..|..
Zfish   330 SLGVGFGVLIAFSSYNKFSNNCYRDAIITSSINSLTSFFSGFVIFSFLGYMSQK-HNVALDKVAT 393

  Fly   333 GGAGLAFISYPEAIAKFEYVP--QMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFGLRSPPIW 395
            .|.||.||.||||||.   :|  .::||:||:||..|||.|.:|....::..:.|:|........
Zfish   394 DGPGLVFIIYPEAIAT---LPGSSVWAVIFFIMLLTLGIDSAMGGMESVITGLIDEFKFLHKHRE 455

  Fly   396 KLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGELVAVAWIYGVNRFCEDIKFM 460
            .....:.|..|.:|::.:|.||.::..|:|.:....:.|...:.|.:.:||.|||:||.:||:.|
Zfish   456 LFTLFIVVSTFLISLICVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGIAWFYGVDRFSDDIEEM 520

  Fly   461 MGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVGYPTLAHVFGCFLATLGLIQLPGWA 525
            :|...|.||||||:|::|..:..:::......:..:|....:||.|.:.|..|:...:|.:|
Zfish   521 IGQRPGLYWRLCWKFVSPCFLLFMVVVSFATFNPPKYGSYYFPTWATMVGWCLSISSMIMVP--- 582

  Fly   526 IYAIYKKRGHNGSFWQRIRAACKP 549
            :||.||.....|||..::..|..|
Zfish   583 LYAFYKFCSLPGSFCDKLAYAITP 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	185/476 (39%)
slc6a3	NP_571830.1	SLC6sbd_DAT1	76..623	CDD:212083	202/539 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820