DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and zgc:158427

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_017207457.1	Gene:	zgc:158427 / 790932	ZFINID:	ZDB-GENE-061215-110	Length:	579	Species:	Danio rerio

Alignment Length:	551	Identity:	186/551 - (33%)
Similarity:	309/551 - (56%)	Gaps:	29/551 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EKPAEQ--WGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEIS 77
            ||..|:  ||...|||.:.....|||||:|||||:.::||||.|:||||:.::..|.|::.||.:
Zfish     6 EKIEERGFWGKKTEFLLAVAGNVVGLGNVWRFPYLCYRNGGGVFLIPYLVFVVTCGVPLFLLETA 70

  Fly    78 LGQFTGRGVVKAFD-MAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWES 141
            :||||..|.:..:. :.||.:|:.....|....|..|::.|:|..|.:.::||.|:|||:.|...
Zfish    71 MGQFTHEGGITCWHRLCPLAQGIGYAGQLTVLYSCMYFTIILAWALFYLISSFSSQLPWASCDNI 135

  Fly   142 WGTD-CHD---GNAQ-NSSGKM-----SPAQLYFEREILHEVPNIDNGLSLPNWQLVACLAIAWL 196
            |.|| |.:   ||.. |.:.:|     |.|..::||.:|.....|:: :...||:::.||...|:
Zfish   136 WNTDNCVNLAAGNLTFNRTTQMLINSTSAATEFWERRVLSLSGGIED-IGKINWEILLCLIAMWI 199

  Fly   197 VIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAA 261
            :....:.:|:||:||..||...||||:|::||:|.:|||||:.||:::..|:...|.:|.||..|
Zfish   200 ICYFCIWKGVKSTGKVVYFTATFPYVMLIVLLIRGLTLPGALQGIVFYLYPEPARLADPQVWMEA 264

  Fly   262 VTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNPD 326
            .||:|||.::..|.||:..|||.:|.|.|.|...:..::|.:|.:||...|.:||.:|...|.|
Zfish   265 GTQIFFSYSVIGGVLISLGSYNQYNNNCYRDCFWLCLLNSGTSFVAGFAVFSVLGFMAHVQGVP- 328

  Fly   327 IGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFGLRS 391
            |..|.:.|.|||||:||:|:|...: ||::||.||:|:.:||:.:......|::..:.|.|
Zfish   329 IEEVAESGPGLAFIAYPQAVAMMPF-PQLWAVCFFIMIILLGLDTQFVSVECVITSVMDLF---- 388

  Fly   392 PPIWKLASG-------LTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALI-LAIGELVAVAWIY 448
            |.:.:.|..       |.:..|...::.:|.||.::..|.|.|..:...|: |::.|.:|:.||:
Zfish   389 PEVLRRAGRRELLVLLLCLTCFFGQLIMVTEGGMYVFQLFDNYACNGACLLFLSVFESLAIGWIF 453

  Fly   449 GVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEY-KGVGYPTLAHVFGCF 512
            |..:..:.|:.|......:::.|||:::||.:.....:|.::..:.|.: :...||..|:|.|..
Zfish   454 GAEKMFDIIEDMTESRPNYWFMLCWKYLTPLVSLTSFVYSMVRYTPLTFNRWYIYPDWAYVLGWL 518

  Fly   513 LATLGLIQLPGWAIYAIYKKRGHNGSFWQRI 543
            ||...::.:|.||:..:...:|.....|:.:
Zfish   519 LALSSILLVPAWALGQMCAGKGSLKQRWRHL 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	171/490 (35%)
zgc:158427	XP_017207457.1	SLC6sbd-TauT-like	11..552	CDD:271387	183/546 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820