DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment List and slc6a4a

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001035061.1	Gene:	slc6a4a / 664719	ZFINID:	ZDB-GENE-060314-1	Length:	646	Species:	Danio rerio

Alignment Length:	571	Identity:	194/571 - (33%)
Similarity:	312/571 - (54%)	Gaps:	38/571 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLG 79
            :.|.|.|...::||.|.|..:|.|||:||||||.:|||||.|::|||:..:..|.|::|:|::||
Zfish    88 DPPRETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYLLMAVFGGVPLFYMELALG 152

  Fly    80 QFTGRGVVKAF-DMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESWG 143
            ||...|.:..: .:.|:.||:.....:.......||::|||..|.:.|:||.:.|||:.|...|.
Zfish   153 QFHRSGCISIWKHVCPIFKGIGFAICIIALYIAFYYNTIMAWALYYLLSSFRATLPWTTCNNRWN 217

  Fly   144 T-DC-H----DGNAQNSSGKMSPAQLYFEREIL--HEVPNIDNGLSLPNWQLVACLAIAWLVIGG 200
            | :| |    |.|...::..:|||:.::.|::|  |..|.: :.|...:|||..||...:.|:..
Zfish   218 TPNCTHYLSTDLNVSWTNNSISPAEEFYVRQVLQVHLSPGL-HQLGWVSWQLALCLLFIFTVVYF 281

  Fly   201 VLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQV 265
            .:.:|:|:|||..:....|||:||||||:|..|||||..|::::.||.|::||...||..|..|:
Zfish   282 SIWKGVKTSGKVVWVTATFPYLVLLILLIRGATLPGAWRGVVFYLKPDWKKLLTTTVWLDAAAQI 346

  Fly   266 FFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLA--RETGNPDIG 328
            ||||...||.|:.:||||.|:.|.|.|.:|.::::..:|.::|.:.|.:||.:|  |:.|   :.
Zfish   347 FFSLGPGFGVLLAFASYNPFHNNCYKDALITSSVNCLTSFLSGFVIFTVLGYMAEMRQQG---VE 408

  Fly   329 SVVK-GGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFGLRSP 392
            :|.| .|..|.||.|.||||... ....||::||||:.:||:.||......::..:.|:|    |
Zfish   409 TVAKDAGPSLLFIIYAEAIANMP-AATFFAIIFFLMIIMLGLDSTFAGLEGVITAMLDEF----P 468

  Fly   393 PI------WKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGELVAVAWIYGVN 451
            .:      | ...||..:.:..::..:|.||.|::.|.:.|......:.:...|::||:|.||..
Zfish   469 HLLARRREW-FVLGLVCVCYLGALSTLTYGGAFVVKLFEEYATGPAVITVVFLEVIAVSWFYGTT 532

  Fly   452 RFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLL---DMSALEYKGVGYPTLAHVFGCFL 513
            |||.|::.|:|...|.:||:||..|.|..:..:::..|.   ::...:|.   ||....|.|..:
Zfish   533 RFCNDVQLMLGFAPGLFWRVCWIAICPCFLLFIIVSFLAFPPEVKLFDYL---YPFWTTVLGYCI 594

  Fly   514 ATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKPSDTWGPANVQLDATI 564
            .....|.:|.:.:|.:...:   |:|.||:.....| :..|.:..|.|..:
Zfish   595 GVSSFICVPSYMVYHLVTTK---GTFQQRLLKGITP-EAPGSSGPQRDTIV 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	176/487 (36%)
slc6a4a	NP_001035061.1	SLC5-6-like_sbd	91..628	CDD:294310	190/553 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820