Protein Alignment List and SLC6A12

DIOPT Version :9

• Sequence 1: NP_611364.2
• Gene: List / 37157
• FlyBaseID: FBgn0034381
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001116319.1
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 206/555 - (37%)
• Similarity: 313/555 - (56%)
• Gaps: 28/555 - (5%)

  Fly    16 KPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLGQ 80
            |...||.|.:||:.|.....:||||:|||||:.::||||.|.|||.|...|.|.||::||::|||
Human    34 KDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQ 98

  Fly    81 FTGRGVVKAF-DMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESWGT 144
            :|.:|.|.|: .:.||.:|:.|..|:..:....||..|:|..|.:..:||.|||||:.|...|.|
Human    99 YTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNT 163

  Fly   145 D-CHDGNAQNSSGKM-------SPAQLYFEREILHEVPNIDNGLSLPNWQLVACLAIAWLVIGGV 201
            : |.|....:.:|.:       ||...::||.:|.....|.:..|| .|:|..||.:||::....
Human   164 EHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSL-RWELALCLLLAWVICYFC 227

  Fly   202 LIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQVF 266
            :.:|:||:||..||...|||::|:|||:|.||||||..||||:.||....|.:|.||..|.||:|
Human   228 IWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIF 292

  Fly   267 FSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDIGSVV 331
            ||.|||.|.|....|||.::.|.|.|.:.:..::|.:|.:||.:.|.|||.:::|.|.| |..|.
Human   293 FSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVP-ISEVA 356

  Fly   332 KGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQF-------GL 389
            :.|.|||||::|:|:.... :.|:::.|||:||..||:.|......|::....|.|       |.
Human   357 ESGPGLAFIAFPKAVTMMP-LSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGR 420

  Fly   390 RSPPIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVS-FTALILAIGELVAVAWIYGVNRF 453
            |...|..:|    |:.:.:.:..:|.||.:|..|.|:|..| ...|.|::.|:|.::|:||.:||
Human   421 RELLILTIA----VMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRF 481

  Fly   454 CEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGV-GYPTLAHVFGCFLATLG 517
            .::|:.|:|.......::.|.|:||||..|..::.|...:.|:|..| .||...:..|.|||...
Human   482 YDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSS 546

  Fly   518 LIQLPGWAIYAIYKKRGHNGSFWQRIRAACKPSDT 552
            ::.:|.:.:..:.|.|   |.|.:|:|....|..:
Human   547 MVCVPLFVVITLLKTR---GPFRKRLRQLITPDSS 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	187/486 (38%)
SLC6A12	NP_001116319.1	SLC6sbd_BGT1	35..575	CDD:212080	204/549 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		0/3 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820