DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and SLC6A6

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001127839.2	Gene:	SLC6A6 / 6533	HGNCID:	11052	Length:	721	Species:	Homo sapiens

Alignment Length:	570	Identity:	195/570 - (34%)
Similarity:	293/570 - (51%)	Gaps:	52/570 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KPAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEI 76
            ||.::  |:|.:.::|:.|.....|||||:|||||:.::||||.|:|||.|.|...|.||::|||
Human   138 KPPQR--EKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEI 200

  Fly    77 SLGQFTGRGVVKAFD-MAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWE 140
            .:||:|..|.:..:: :.||..|:....|:..:....||..|:|....:...||..||||:.|..
Human   201 IIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNH 265

  Fly   141 SWGT-DCHDGNAQ---------NSSGKMSPAQLYFEREILHEVPNIDNGLSLPNWQLVACLAIAW 195
            ||.| .|.:...:         :|:...||...::||.:|...|.||:..|| .|.|..||.:.|
Human   266 SWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSL-KWDLALCLLLVW 329

  Fly   196 LVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYA 260
            ||....:.:|::|:||..||...||:.:||:||:|.:|||||..||.::..|....|.:|.||..
Human   330 LVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWID 394

  Fly   261 AVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNP 325
            |.||:|||.|||.|.:.:..|||.:..|.|.|.:::..::|.:|.::|...|.|||.:|:|.| .
Human   395 AGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQG-V 458

  Fly   326 DIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLG-----------IGSTVGMGSCI 379
            ||..|.:.|.|||||:||:|:.... :|..:::|||:||.:||           |.|.|.:....
Human   459 DIADVAESGPGLAFIAYPKAVTMMP-LPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSF 522

  Fly   380 LRVIRDQFGLRSPPIWKLASGLTVLGFSVSIVYM------TPGGQFILNLVDFYGVSFTALI-LA 437
            ||.     |.|..         ..:.|..||.|:      |.||.::..|.|:|..|...|: :|
Human   523 LRK-----GYRRE---------IFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVA 573

  Fly   438 IGELVAVAWIYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEY-KGVG 501
            ..|...:|||||.:...:.|:.|:|...|.:.:..|..|||.|.....|:.|:....|.| |...
Human   574 FFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYV 638

  Fly   502 YPTLAHVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKPSD 551
            ||..|...|..||...::.:|   :..:.:.....|.|..|::....|.:
Human   639 YPNWAIGLGWSLALSSMLCVP---LVIVIRLCQTEGPFLVRVKYLLTPRE 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	178/498 (36%)
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	192/562 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820