DRSC/TRiP Functional Genomics Resources

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Protein Alignment List and SLC6A4

DIOPT Version :9

Sequence 1:NP_611364.2 Gene:List / 37157 FlyBaseID:FBgn0034381 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_001036.1 Gene:SLC6A4 / 6532 HGNCID:11050 Length:630 Species:Homo sapiens


Alignment Length:551 Identity:193/551 - (35%)
Similarity:303/551 - (54%) Gaps:36/551 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 EQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLGQFTG 83
            |.||..::||.|.|..:|.|||:||||||.:|||||.|::||.|..:..|.|::|:|::|||:..
Human    80 ETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHR 144

  Fly    84 RGVVKAF-DMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESWGTDCH 147
            .|.:..: .:.|:.||:.....:......:||::|||..|.:.::||..:|||:.|..||.|   
Human   145 NGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNT--- 206

  Fly   148 DGNAQN---------SSGKMSPAQLYFEREIL--HEVPNIDN--GLSLPNWQLVACLAIAWLVIG 199
             ||..|         :....|||:.::.|.:|  |....:.:  |:|   |||..|:.:.:.||.
Human   207 -GNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGIS---WQLALCIMLIFTVIY 267

  Fly   200 GVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQ 264
            ..:.:|:|:|||..:....|||::|.:||:|..|||||..|::::.||.|::||...||..|..|
Human   268 FSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQ 332

  Fly   265 VFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDIGS 329
            :||||...||.|:.:||||.||.|.|.|.::.:.::..:|.::|.:.|.:||.:| |..|.|:..
Human   333 IFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMA-EMRNEDVSE 396

  Fly   330 VVK-GGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFGLRSPP 393
            |.| .|..|.||:|.||||... ....||::|||||..||:.||......::..:.|:|    |.
Human   397 VAKDAGPSLLFITYAEAIANMP-ASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEF----PH 456

  Fly   394 IW-----KLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGELVAVAWIYGVNRF 453
            :|     :....:.:..|..|:|.:|.||.:::.|::.|......|.:|:.|.|||:|.||:.:|
Human   457 VWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQF 521

  Fly   454 CEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVGYPTLAHVFGCFLATLGL 518
            |.|:|.|:|...||:||:||..|:|..:..::...|:....|......||..:.:.|..:.|...
Human   522 CRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSF 586

  Fly   519 IQLPGWAIYAIYKKRGHNGSFWQRIRAACKP 549
            |.:|   .|..|:.....|:|.:||..:..|
Human   587 ICIP---TYIAYRLIITPGTFKERIIKSITP 614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ListNP_611364.2 SLC6sbd 19..489 CDD:271359 178/489 (36%)
SLC6A4NP_001036.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..59
5HT_transport_N 24..64 CDD:397524
SLC6sbd_SERT 79..615 CDD:271399 193/551 (35%)
Interaction with RAB4A 616..624
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D250396at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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