DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and SLC6A3

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001035.1	Gene:	SLC6A3 / 6531	HGNCID:	11049	Length:	620	Species:	Homo sapiens

Alignment Length:	564	Identity:	209/564 - (37%)
Similarity:	316/564 - (56%)	Gaps:	23/564 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTQLEISKKSEKPAE-KPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIAL 64
            :|...::...:.|.| :..|.||..::||.|.|..:|.|.|:|||||:.::||||.|::|||:.:
Human    42 LTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFM 106

  Fly    65 LVIGRPVYYLEISLGQFTGRGVVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASF 129
            ::.|.|::|:|::||||...|....:.:.|:||||....:|.:.....:|:.|:|..|.:..:||
Human   107 VIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSF 171

  Fly   130 GSELPWSRCWESWGT-DCHDGNAQNSSGKMS---------PAQLYFEREI--LHEVPNIDNGLSL 182
            .:||||..|..||.: :|.|.:..:|||..|         ||..||||.:  ||:...||: |..
Human   172 TTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDD-LGP 235

  Fly   183 PNWQLVACLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKP 247
            |.|||.|||.:..:::...|.:|:|:|||..:.....|||||..||||.||||||||||..:...
Human   236 PRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV 300

  Fly   248 QWRELLNPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITF 312
            .:..|....||..|.|||.|||.:.||.||.::|||.|..|.|.|.::.|:::|.:|..:|.:.|
Human   301 DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVF 365

  Fly   313 GILGNLARETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGS 377
            ..||.:|::...| ||.|.|.|.||.||.||||||... :...:||:||:||..|||.|.:|...
Human   366 SFLGYMAQKHSVP-IGDVAKDGPGLIFIIYPEAIATLP-LSSAWAVVFFIMLLTLGIDSAMGGME 428

  Fly   378 CILRVIRDQFGL--RSPPIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGE 440
            .::..:.|:|.|  |...::.|.  :.:..|.:|:..:|.||.::..|:|.:....:.|...:.|
Human   429 SVITGLIDEFQLLHRHRELFTLF--IVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIE 491

  Fly   441 LVAVAWIYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVGYPTL 505
            .:.|||.|||.:|.:||:.|.|.....||||||:.::|..:..|::..::......|....:|..
Human   492 AIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDW 556

  Fly   506 AHVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKP 549
            |:..|..:||..:..:|   |||.||.....|||.:::..|..|
Human   557 ANALGWVIATSSMAMVP---IYAAYKFCSLPGSFREKLAYAIAP 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	189/483 (39%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	206/546 (38%)
SLC6A3	NP_001035.1	Interaction with TGFB1I1. /evidence=ECO:0000269\|PubMed:12177201	561..590		12/31 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820