DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and SLC6A2

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001165975.1	Gene:	SLC6A2 / 6530	HGNCID:	11048	Length:	628	Species:	Homo sapiens

Alignment Length:	549	Identity:	196/549 - (35%)
Similarity:	305/549 - (55%)	Gaps:	19/549 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLGQ 80
            :|.|.||..::||.|.:..:|.|.|:|||||:.::||||.|:|||.:.|::.|.|::|:|::|||
Human    54 QPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQ 118

  Fly    81 FTGRGVVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESWGT- 144
            :...|....:.:.|..|||....:|.......||:.|:|.:|.:..:||...|||:.|..:|.:
Human   119 YNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSP 183

  Fly   145 DCHD---------GN-AQNSSGKMSPAQLYFEREI--LHEVPNIDNGLSLPNWQLVACLAIAWLV 197
            :|.|         || .:.|..|.:||..::||.:  |||...| :.:.||.|||:.||.:..:|
Human   184 NCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGI-HDIGLPQWQLLLCLMVVVIV 247

  Fly   198 IGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAV 262
            :...|.:|:|:|||..:.....||.||.:||:..||||||.:||..:....:..|....||..|.
Human   248 LYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAA 312

  Fly   263 TQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDI 327
            ||:||||...||.||.:||||.|:.|.|.|.::.::::..:|.::|...|.|||.:|.| ...:|
Human   313 TQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHE-HKVNI 376

  Fly   328 GSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFGLRSP 392
            ..|...||||.||.|||||:... ....:||:||:||..||:.|::|....::..:.|.|.:...
Human   377 EDVATEGAGLVFILYPEAISTLS-GSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKR 440

  Fly   393 PIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGELVAVAWIYGVNRFCEDI 457
            .......|:|...|.:::..:|.||.::|.|:|.:....:.|...:.|.:.|:|.|||:||..||
Human   441 HRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDI 505

  Fly   458 KFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVGYPTLAHVFGCFLATLGLIQLP 522
            :.|||...|.||||||:|::|..:..|::..:::...|.|....:|..|:..|..:|...::.:|
Human   506 QQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVP 570

  Fly   523 GWAIYAIYKKRGHNGSFWQRIRAACKPSD 551
               ||.|||.....||.|:|:.....|.:
Human   571 ---IYVIYKFLSTQGSLWERLAYGITPEN 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	178/482 (37%)
SLC6A2	NP_001165975.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
SLC6A2	NP_001165975.1	SLC6sbd_NET	56..612	CDD:212081	195/547 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820