DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and si:ch211-132b12.2

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001038688.1	Gene:	si:ch211-132b12.2 / 571877	ZFINID:	ZDB-GENE-050420-178	Length:	582	Species:	Danio rerio

Alignment Length:	550	Identity:	183/550 - (33%)
Similarity:	300/550 - (54%)	Gaps:	29/550 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLGQFTGRG 85
            ||:..||:.:...:.:||||:|||||:.::||||.|::|||:.::..|.|::.||.::||:|..|
Zfish    14 WGSKTEFILAVAGIVIGLGNVWRFPYLCYKNGGGAFLVPYLVFVVTCGVPLFLLETAMGQYTQEG 78

  Fly    86 VVKAFD-MAPLLKGVALGQVLATAASITYYSSIMALTLRFWLA-SFGSELPWSRCWESWGTDCHD 148
            .:..:. :.||.:|:.....|....|..||..|:|..| |:|| ||.|:|||:.|...|.||...
Zfish    79 GITCWHRLCPLAEGIGYAGQLIVLYSCMYYIIILAWAL-FYLAFSFSSQLPWASCDNIWNTDACV 142

  Fly   149 GNAQNSSGKMSPAQLYFEREIL----HEVPNIDNGLSLP---NWQLVACLAIAWLVIGGVLIRGI 206
            ..|:|.....:|..|.....:.    |.|..:..|:...   ||:::.||.:.|::....:.:|:
Zfish   143 NLAENKLNLSTPMLLNSTSSVTEFWQHRVLALSGGIEKVGKINWEILLCLIVMWIICYFCVWKGV 207

  Fly   207 KSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQVFFSLAI 271
            ||:||..||...||||:||:||:|.:|||||:.|::::..|:...|.:|.||..|..|:|||.|:
Zfish   208 KSTGKVVYFTATFPYVMLLVLLIRGLTLPGALQGVVFYLYPEPARLADPQVWMEAGAQIFFSYAL 272

  Fly   272 CFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDIGSVVKGGAG 336
            ...:|....|||.:|.|.|...:.:..::|.:|:|||...|.:||.:|::.|.| |..|.:.|.|
Zfish   273 GTASLTVLGSYNKYNYNCYRSSLWLCLLNSSTSVIAGFAVFSVLGFMAQKQGLP-IEEVAESGPG 336

  Fly   337 LAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFGLRSPPIWKLASG- 400
            ||||:||:|:|...: ||::|..||:|:.:||:.:........:..:.|.|    |.:.:.|..
Zfish   337 LAFIAYPQAVAMMPF-PQLWAACFFIMIILLGLDTQFVAMEVFMTSVIDLF----PTVLRKAGRR 396

  Fly   401 ------LTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALI-LAIGELVAVAWIYGVNRFCEDIK 458
                  ..:..|...:|.:|.||.::..|.|:|..|...|: |.:.|.:|:.|::|..:....|:
Zfish   397 EIFLLLFCLFCFFGQLVMVTEGGMYVFQLFDYYACSGACLLFLCVFESLAMGWVFGAEKMFGIIE 461

  Fly   459 FMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEY-KGVGYPTLAHVFGCFLATLGLIQLP 522
            .|......:::.|||:::||.:..|..:..|:....|.: :...||..|:|.|..||...::.:|
Zfish   462 DMTNSRPNYWFMLCWKYLTPIVSLASFVCSLVKYKPLTFNRWYVYPDWAYVLGWLLALSSILLVP 526

  Fly   523 GWAIYAIYKKRGHNGSFWQRIRAACKPSDT 552
            |||:..::..:   ||..||....|.| ||
Zfish   527 GWALGRMFAGK---GSIKQRWSHLCSP-DT 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	162/484 (33%)
si:ch211-132b12.2	NP_001038688.1	SLC6sbd-TauT-like	11..550	CDD:271387	180/545 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820