DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and slc6a1l

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_021330952.1	Gene:	slc6a1l / 568985	ZFINID:	ZDB-GENE-041210-296	Length:	578	Species:	Danio rerio

Alignment Length:	558	Identity:	183/558 - (32%)
Similarity:	304/558 - (54%)	Gaps:	24/558 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LEISKKSEKPAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIG 68
            :.:.:|..|..::.:  |....:||.||:..::||||:|||||:..:||||.|:|||...|:..|
Zfish    15 IPVEEKENKIPDRGS--WKGKFDFLLSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFTTLVFAG 77

  Fly    69 RPVYYLEISLGQFTGRGVVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSEL 133
            .|::.||.:|||:|..|.:..:.:.|::|||.|..|:.:.....||..|:|..|.:..:|..:||
Zfish    78 IPLFLLETALGQYTSVGGLGVWKLIPMMKGVGLAAVVLSFWLNIYYIIIIAWALYYLFSSLKAEL 142

  Fly   134 PWSRCWESWGTD-CHDGNAQNSSGKMSPAQLYFEREILHEVPNIDNGLSLP---NWQLVACLAIA 194
            ||..|...|.|| |....:...:..:|.|...|....:|:   :.|||..|   .|.||..||::
Zfish   143 PWQTCDNPWNTDRCFSNYSLLDTTNLSSAVTEFWERNMHQ---LTNGLEEPGELRWPLVGTLALS 204

  Fly   195 WLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWY 259
            |:::...:.:|::.:||..||...:||.:|.||..|.|||||||||::::..|.:.:||...||.
Zfish   205 WILVYFSIWKGVEWTGKVVYFSATYPYFMLFILFFRGVTLPGAIDGVLFYITPNFNKLLKSEVWL 269

  Fly   260 AAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGN 324
            .|.||:|||..:..|:||...|||:||.|||.|.||:..::||:|:.||.:.|.|:|.::..|..
Zfish   270 DAATQIFFSYGLGLGSLIALGSYNSFNNNVYRDSVIVCCINSCTSMFAGIVIFSIVGFMSYITKR 334

  Fly   325 PDIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFGL 389
            | |..:...|.||||::||:|:.:.. :..::|:|||.||.:||:.|........:..:.|::
Zfish   335 P-IEELAASGPGLAFLAYPQAVTQLP-MSSLWAILFFSMLMMLGLDSQFCTVEGFITALMDEY-- 395

  Fly   390 RSPPIWKLASGLTVL-----GFSVSIVYMTPGGQFILNLVDFYGVS-FTALILAIGELVAVAWIY 448
              |.:.:....:.:|     .|.:....:|.||.::..|.|:|..| ...|.|...|.:::||.|
Zfish   396 --PTVLRKRKKIFILIVCLVSFIIGFSNITQGGLYVFKLFDYYSASGMCLLFLVFFETISIAWFY 458

  Fly   449 GVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVGYPTLAHVFGCFL 513
            |..:|.::|:.|:|.....:|:.||.:.||.:...|..:..::|:.|......||......|..:
Zfish   459 GAEKFYKNIEEMIGYRPCGFWKQCWIYFTPTICLGVFTFSAIEMTPLTLGKYVYPAWGQGVGWLM 523

  Fly   514 ATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKPSD 551
            :...::.:||:.||..:..:|:....|.::   .||::
Zfish   524 SLSSMVLIPGYIIYMFFSTKGNIRQRWHKM---TKPTE 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	168/479 (35%)
slc6a1l	XP_021330952.1	SLC5-6-like_sbd	15..558	CDD:320982	183/556 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820