DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment List and Slc6a14

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_064433.3	Gene:	Slc6a14 / 56774	MGIID:	1890216	Length:	638	Species:	Mus musculus

Alignment Length:	580	Identity:	210/580 - (36%)
Similarity:	315/580 - (54%)	Gaps:	59/580 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLGQFTGRG 85
            |....::|.|.:..:|||||:|||||:.:.||||.|:|||.|.|.:.|.|:::||.|||||...|
Mouse    39 WSKKSDYLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLG 103

  Fly    86 VVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESWGTD----- 145
            .|..:.:.||.:||.:..||.:.....||:.|:|.:|.:..|||.|.|||:.| .||..:
Mouse   104 PVSVWRILPLFQGVGITMVLISVFVAIYYNVIIAYSLYYLFASFQSVLPWANC-SSWADENCSRT 167

  Fly   146 ----------------------------CHDGNAQNSSGKMSPAQLYFEREILHEVPNID-NGLS 181
                                        |.:|:.....|:: |::.|:::..|.....:| .|:.
Mouse   168 PIVTGCNVSIGAGEMFMNISWVNTNNLTCLNGSEVFRPGQL-PSEQYWDKVTLQRSSGMDETGVV 231

  Fly   182 LPNWQLVACLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFK 246
            :  |.|..||.:|||::|..|.:|||||||..||..:||||||||||:|..||.||..||.|:..
Mouse   232 V--WYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLIRGATLEGASKGISYYIG 294

  Fly   247 PQ--WRELLNPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGC 309
            .|  :.:|....||..|.||:|:||::.:|.|:..:|||.||.|.|:|.:|:...:..:|:.||.
Mouse   295 AQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSSYNKFNNNCYSDAIIVCLTNCLTSVFAGF 359

  Fly   310 ITFGILGNLARETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVG 374
            ..|.|||::|..:|. ::..|||.|..||||:||||:|:....| .:::|||.||..||:.|...
Mouse   360 AIFSILGHMAHISGK-EVSQVVKSGFDLAFIAYPEALAQLPAGP-FWSILFFFMLLTLGLDSQFA 422

  Fly   375 MGSCILRVIRDQF-----GLRSPPIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTAL 434
            ....|....:|.|     .:|.|    :..|..::.|.:.::.:|..|.:.::|:|.:...:..|
Mouse   423 SIETITTTFQDLFPKAMKRMRVP----ITLGCCLILFLLGLLCVTQAGIYWVHLIDHFCAGWGIL 483

  Fly   435 ILAIGELVAVAWIYGVNRFCEDIKFMMGIETGW----YWRLCWRFITPGLMTAVLIYMLLDMSAL 495
            |.||.|:..:.||||.|||.|||:.|:|.:. |    :||.||..|||.|::|:|::.|:.....
Mouse   484 IAAILEIAGIIWIYGGNRFIEDIEMMIGAKR-WIFWLWWRACWFVITPILLSAILVWSLVKFHRP 547

  Fly   496 EYKGVGYPTLAHVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKPSDTWGP 555
            :|..:.||......|..:....:|.:|   |.||.|.....|:..|||.:.|:|:..|||
Mouse   548 DYADIPYPDWGVALGWCMIIFCIIWIP---IMAIIKIVQAEGNILQRIISCCRPASNWGP 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	190/512 (37%)
Slc6a14	NP_064433.3	SLC5-6-like_sbd	36..637	CDD:294310	210/580 (36%)
Slc6a14	NP_064433.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..638
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920