DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and slc6a7

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_005161359.1	Gene:	slc6a7 / 562050	ZFINID:	ZDB-GENE-070112-1492	Length:	652	Species:	Danio rerio

Alignment Length:	569	Identity:	212/569 - (37%)
Similarity:	325/569 - (57%)	Gaps:	31/569 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SKKSEKPAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPV 71
            |..:..||:.|.:|||...|||.|||...|||||:|||||:.::||||.|:|||.|.|...|.|:
Zfish    60 SSAASPPAQPPRDQWGGKYEFLLSCIGYCVGLGNVWRFPYLCYRNGGGVFLIPYFIMLFFTGMPL 124

  Fly    72 YYLEISLGQFTGRGVVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWS 136
            :.:|:||||:...|.:..:...|||||:.:|.:..:.....||:.|:|.|..:..:||.|.||||
Zfish   125 FLMELSLGQYGAAGPITVWKCCPLLKGIGIGMLCVSTLVCLYYNVIIAWTFYYLGSSFQSPLPWS 189

  Fly   137 RCWESWGTDCHDGNAQNSSGKMSPAQLYFEREILHEVPNIDNGLSLP---NWQLVACLAIAWLVI 198
             | ::........|..||:  .||:::::..::|..|.:  .|||.|   .|.|..||..||::|
Zfish   190 -C-DALQNIALCANKTNST--QSPSEVFWNEKVLGVVHS--TGLSDPGPVRWPLALCLLAAWIII 248

  Fly   199 GGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVT 263
            ...:::||.||||..|....|||.|||:|::|..||.|::||:.::..|:|.:|.:..||..|.:
Zfish   249 FLCMLKGIHSSGKVVYVTATFPYFVLLVLIIRGATLEGSLDGVAFYLTPKWDQLADAQVWNDAAS 313

  Fly   264 QVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDIG 328
            |:|:||.|..|.|::.||||.|:.||..|.:|||..:..:|..||...|.|||::|.:.|.| :.
Zfish   314 QIFYSLGIGVGGLLSMASYNKFDNNVIRDTIIITIGNCSTSFFAGFAIFSILGHMAFKKGVP-VD 377

  Fly   329 SVVKGGAGLAFISYPEAIAKFEYVP--QMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQF-GLR 390
            .|...|.||||::||||:|   .:|  ..:::|||||||:||:.:..|....|...:.|:| .||
Zfish   378 KVADSGPGLAFVAYPEALA---LLPGSVFWSILFFLMLFMLGVDTLFGNMEGICTAVLDEFPQLR 439

  Fly   391 SPPIWKLASGLTVLGFS---VSIVYMTPGGQFILNLVDFYGVSFTALILAIGELVAVAWIYGVNR 452
            |....|... |.||.||   :.::.:|.||.:...|:|.:..||..:|:.:...:.:::.||||:
Zfish   440 SNLKHKTLF-LAVLCFSFYLMGLLLITDGGIYWFTLIDSFSTSFGLIIITLFMCIGISFFYGVNQ 503

  Fly   453 FCEDIKFMMGIETGW------YWRLCWRFITPGLMTAVLIYMLLDM--SALEYKGVGYPTLAHVF 509
            ||:||..|:.....|      |::.||...||.|:|.:|.|:.::|  ::|.|....||......
Zfish   504 FCQDIVDMICRCPPWCTKMLLYFKACWVVFTPFLLTFILTYIFIEMYRTSLRYGSYVYPIWGKAL 568

  Fly   510 GCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKPSDTWGPANV 558
            |..:..|..:|:..|||.||.|:   :|:...|.:.:.:|.::|...|:
Zfish   569 GVCMGALCCLQILIWAIVAISKE---SGTLKDRFKKSIRPLNSWRVNNI 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	189/484 (39%)
slc6a7	XP_005161359.1	SLC5-6-like_sbd	71..610	CDD:294310	206/552 (37%)
slc6a7	XP_005161359.1	PotE	<235..564	CDD:223605	127/333 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920